Search Results - "Kennedy, RD"

The Fanconi Anemia/BRCA pathway: new faces in the crowd by Kennedy, Richard D, D'Andrea, Alan D

“…Over the past few years, study of the rare inherited chromosome instability disorder, Fanconi Anemia (FA), has uncovered a novel DNA damage response pathway…”
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Development and Independent Validation of a Prognostic Assay for Stage II Colon Cancer Using Formalin-Fixed Paraffin-Embedded Tissue by KENNEDY, Richard D, BYLESJO, Max, GOFFARD, Nicolas, HEY, Peter, MCDYER, Fionnuala, MULLIGAN, Karl, MUSSEN, Julie, O'BRIEN, Eamonn, OLIVER, Gavin, WALKER, Steven M, MULLIGAN, Jude M, WILSON, Claire, KERR, Peter, WINTER, Andreas, O'DONOGHUE, Diarmuid, MULCAHY, Hugh, O'SULLIVAN, Jacintha, SHEAHAN, Kieran, HYLAND, John, DHIR, Rajiv, BATHE, Oliver F, WINQVIST, Ola, MANNE, Upender, DAVISON, Timothy, SHANMUGAM, Chandrakumar, RAMASWAMY, Sridhar, LEON, Eduardo J, SMITH, William I, MCDERMOTT, Ultan, WILSON, Richard H, LONGLEY, Daniel, MARSHALL, John, CUMMINS, Robert, SARGENT, Daniel J, BLACK, Julie M, JOHNSTON, Patrick G, PAUL HARKIN, D, KAY, Elaine W, HOLT, Robert J, PROUTSKI, Vitali, AHDESMAKI, Miika, FARZTDINOV, Vadim

“…Current prognostic factors are poor at identifying patients at risk of disease recurrence after surgery for stage II colon cancer. Here we describe a DNA…”
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Abstract P3-11-12: Biomarker phase neo-DDRD trial: Predicting response to neoadjuvant chemotherapy (NAC) in early breast cancer using the DNA damage repair deficiency (DDRD) assay by Parkes, EE, James, CR, Lioe, T, Walker, S, Savage, KI, Lowry, K, Knight, L, McCavigan, A, Logan, G, Hurwitz, J, Kirk, SJ, Harkin, P, Kennedy, RD, McIntosh, SA

“…Abstract Background: The DDRD assay was developed to prospectively identify a molecular subtype of cancers defined by DNA damage activated immune signalling…”
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The Role of BRCA1 in the Cellular Response to Chemotherapy by Kennedy, Richard D., Quinn, Jennifer E., Mullan, Paul B., Johnston, Patrick G., Harkin, D. Paul

“…Germline mutations of the BRCA1 gene account for approximately 5% of breast and ovarian cancer cases, and lower than normal BRCA1 expression or function may be…”
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BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis by QUINN, Jennifer E, KENNEDY, Richard D, MULLAN, Paul B, GILMORE, Paula M, CARTY, Michael, JOHNSTON, Patrick G, HARKIN, D. Paul

“…We have evaluated the role played by BRCA1 in mediating the phenotypic response to a range of chemotherapeutic agents commonly used in cancer treatment. Here…”
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Smoking among female daily smokers in Surabaya, Indonesia by Hardesty, J.J., Kaplan, B., Martini, S., Megatsari, H., Kennedy, R.D., Cohen, J.E.

“…Nationally representative studies suggest 1–2% of Indonesian women (2.3 million) smoke various tobacco products daily; however, in recent years, there has been…”
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Abstract OT3-02-07: Neo-DDRD: A biomarker-driven neoadjuvant feasibility study in breast cancer by McIntosh, SA, Parkes, EE, James, CR, Lioe, T, Lowry, K, Keating, KE, Khambata-Ford, S, Kennedy, RD

“…Abstract Background Anthracycline-based chemotherapy reduces the risk of early breast cancer recurrence but to date it has not been possible to predict which…”
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Elder abuse and neglect: the experience, knowledge, and attitudes of primary care physicians by Kennedy, Richard D

“…Two million elderly Americans are abused or neglected each year. Elderly patients visit their physicians approximately five times each year. Yet physicians…”
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Metallacarborane-Based Metal-Organic Framework with a Complex Topology by Kennedy, RD, Clingerman, DJ, Morris, W, Wilmer, CE, Sarjeant, AA, Stern, CL, O'Keeffe, M, Snurr, RQ, Hupp, JT, Farha, OK, Mirkin, CA

“…The long, linear cobalt(III) bis(dicarbollide)-based bis(isophthalic acid) anion was synthesized as a tetraphenylphosphonium salt in five steps from…”
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Smoking cessation counseling from health care providers before and after the national smoke-free law : findings from the ITC France Study by Kennedy, Rd, Behm, I, Craig, L, Thompson, Me, Fong, Gt, Guignard, R, Beck, François

“…Background: Smoking cessation advice from health care providers (HCP) is well-known to be associated with increased quitting. This study sought to understand…”
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Outdoor smoking behaviour and support for outdoor smoking restrictions before and after the France national smoking ban : findings from the ITC France study by Kennedy, Rd, Behm, I, Craig, L, Thompson, Me, Fong, Gt, Guignard, R, Beck, François

“…On January 1, 2008, the French government implemented a national ban on indoor smoking in hospitality venues. Survey results indicate the indoor ban has been…”
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Carborane-Based Metal-Organic Framework with High Methane and Hydrogen Storage Capacities by Kennedy, RD, Krungleviciute, V, Clingerman, DJ, Mondloch, JE, Peng, Y, Wilmer, CE, Sarjeant, AA, Snurr, RQ, Hupp, JT, Yildirim, T, Farha, OK, Mirkin, CA

“…A Cu-carborane-based metal organic framework (MOF), NU-135, which contains a quasi-spherical para-carborane moiety, has been synthesized and characterized…”
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Strategies to help patients stop smoking: the optometrist's perspective by Kennedy, Ryan David, Douglas, Ornell

“…The following review article discusses tobacco's toll on individual and public health, and presents what is currently known about cigarette smoking's risk to…”
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P5-01-12: Identification of an ATM Activation Subtype in PTEN Mutant Breast Tumours by McCabe, N, Walker, SM, Goffard, N, Wikstrom, K, Greenan, C, Delaney, T, McCarthy, M, McDyer, F, Hill, L, Deharo, S, Proutski, V, Keating, K, Mullan, P, Harkin, DP, Kennedy, RD

“…Abstract Background PTEN is frequently lost in cancer cells through genetic mutation or epigenetic silencing. Loss of PTEN function has been widely reported to…”
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BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene by Kennedy, Richard D, Gorski, Julia J, Quinn, Jennifer E, Stewart, Gail E, James, Colin R, Moore, Stephen, Mulligan, Karl, Emberley, Ethan D, Lioe, Tong F, Morrison, Patrick J, Mullan, Paul B, Reid, George, Johnston, Patrick G, Watson, Peter H, Harkin, D Paul

“…Evidence is accumulating to suggest that some of the diverse functions associated with BRCA1 may relate to its ability to transcriptionally regulate key…”
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BRCA1: mechanisms of inactivation and implications for management of patients by Kennedy, Richard D, Quinn, Jennifer E, Johnston, Patrick G, Harkin, D Paul

“…The BRCA1 gene was cloned in 1994 as one of the genes that conferred genetic predisposition to early-onset breast and ovarian cancer. Since then, a genetic…”
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Abstract P6-04-14: Impact of Estrogen Receptor Alpha Signalling in the Molecular Profiling of FFPE Derived BRCAl-Deficient Breast Tumours by Quinn, JE, Lamers, E, Irwin, GW, Cochrane, D, McDyer, FA, Mulligan, JM, Couch, FJ, Kennedy, RD, Harkin, PD

“…Abstract Background: Approximately 5-10% of all breast cancers are hereditary and the majority of these arise due to germline mutations in the BRCA1 and BRCA2…”
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PD10-05: Identification of Novel BRCA1 Transcriptional Targets That Promote the Survival of BRCA1-Mutated Estrogen Receptor-a Negative (ER-ve) Breast Tumours by Lamers, E, Haddock, P, Cochrane, DJ, Gorski, JJ, Blayney, J, McDyer, FA, Mulligan, JM, Mullan, PB, Couch, FJ, Kennedy, RD, Harkin, PD, Quinn, JE

“…Abstract Background: The BRCA1 tumour suppressor gene is mutated in the germline of women who are predisposed to developing breast cancer. Gene expression…”
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The 2,5 oligoadenylate synthetase RNaseL pathway is a novel effector of BRCA1- and interferon-γ-mediated apoptosis by Mullan, Paul B, Hosey, Alison M, Buckley, Niamh E, Quinn, Jennifer E, Kennedy, Richard D, Johnston, Patrick G, Harkin, D Paul

“…BRCA1 has been reported to have roles in DNA damage repair, cell cycle checkpoint control, transcriptional regulation and ubiquitination. We have previously…”
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Microarray based expression profiling of BRCA1 mutated human tumours using a breast-specific platform to identify a profile of BRCA1 deficiency by Lamers, E, McDyer, FA, Mulligan, JM, Couch, F, Savage, KI, O'Brien, NE, Mullan, PB, Kennedy, RD, Harkin, DP, Quinn, JE

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