Search Results - "Kennedy, Philippa R."

Challenges to the broad application of allogeneic natural killer cell immunotherapy of cancer by Kennedy, Philippa R, Felices, Martin, Miller, Jeffrey S

“…Natural killer (NK) cells are innate immune cells that recognize malignant cells through a wide array of germline-encoded receptors. Triggering of activating…”
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The Size of Activating and Inhibitory Killer Ig-like Receptor Nanoclusters Is Controlled by the Transmembrane Sequence and Affects Signaling by Oszmiana, Anna, Williamson, David J., Cordoba, Shaun-Paul, Morgan, David J., Kennedy, Philippa R., Stacey, Kevin, Davis, Daniel M.

“…Super-resolution microscopy has revealed that immune cell receptors are organized in nanoscale clusters at cell surfaces and immune synapses. However,…”
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A tri-specific killer engager against mesothelin targets NK cells towards lung cancer by Kennedy, Philippa R, Vallera, Daniel A, Ettestad, Brianna, Hallstrom, Caroline, Kodal, Behiye, Todhunter, Deborah A, Bendzick, Laura, Hinderlie, Peter, Walker, Joshua T, Pulkrabek, Brittany, Pastan, Ira, Kratzke, Robert A, Fujioka, Naomi, Miller, Jeffrey S, Felices, Martin

“…New treatments are required to enhance current therapies for lung cancer. Mesothelin is a surface protein overexpressed in non-small cell lung cancer (NSCLC)…”
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HLA-B and HLA-C Differ in Their Nanoscale Organization at Cell Surfaces by Kennedy, Philippa R, Barthen, Charlotte, Williamson, David J, Davis, Daniel M

“…The particular HLA class I variants an individual carries influences their resistance and susceptibility to a multitude of diseases. Expression level and…”
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NK Cells Augment Oncolytic Adenovirus Cytotoxicity in Ovarian Cancer by Leung, Elaine Y.L., Ennis, Darren P., Kennedy, Philippa R., Hansell, Christopher, Dowson, Suzanne, Farquharson, Malcolm, Spiliopoulou, Pavlina, Nautiyal, Jaya, McNamara, Sophie, Carlin, Leo M., Fisher, Kerry, Davis, Daniel M., Graham, Gerard, McNeish, Iain A.

“…Oncolytic viruses (OVs) can trigger profound innate and adaptive immune responses, which have the potential both to potentiate and reduce the activity of OVs…”
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Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation by Xiong, Shiqiu, Sharkey, Andrew M, Kennedy, Philippa R, Gardner, Lucy, Farrell, Lydia E, Chazara, Olympe, Bauer, Julien, Hiby, Susan E, Colucci, Francesco, Moffett, Ashley

“…Reduced trophoblast invasion and vascular conversion in decidua are thought to be the primary defect of common pregnancy disorders including preeclampsia and…”
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Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy by Kennedy, Philippa R, Chazara, Olympe, Gardner, Lucy, Ivarsson, Martin A, Farrell, Lydia E, Xiong, Shiqiu, Hiby, Susan E, Colucci, Francesco, Sharkey, Andrew M, Moffett, Ashley

“…Tissue-specific NK cells are abundant in the pregnant uterus and interact with invading placental trophoblast cells that transform the maternal arteries to…”
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The effect of pregnancy on the uterine NK cell KIR repertoire by Male, Victoria, Sharkey, Andrew, Masters, Leanne, Kennedy, Philippa R., Farrell, Lydia E., Moffett, Ashley

“…The major leukocyte population in the decidua during the first trimester of pregnancy consists of NK cells that express receptors capable of recognizing MHC…”
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Tissue-Specific Education of Decidual NK Cells by Sharkey, Andrew M, Xiong, Shiqiu, Kennedy, Philippa R, Gardner, Lucy, Farrell, Lydia E, Chazara, Olympe, Ivarsson, Martin A, Hiby, Susan E, Colucci, Francesco, Moffett, Ashley

“…During human pregnancy, fetal trophoblast cells invade the decidua and remodel maternal spiral arteries to establish adequate nutrition during gestation…”
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Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing by Smith, Samantha L., Kennedy, Philippa R., Stacey, Kevin B., Worboys, Jonathan D., Yarwood, Annie, Seo, Seungmae, Solloa, Everardo Hegewisch, Mistretta, Brandon, Chatterjee, Sujash S., Gunaratne, Preethi, Allette, Kimaada, Wang, Ying-Chih, Smith, Melissa Laird, Sebra, Robert, Mace, Emily M., Horowitz, Amir, Thomson, Wendy, Martin, Paul, Eyre, Steve, Davis, Daniel M.

“…Human natural killer (NK) cells in peripheral blood perform many functions, and classification of specific subsets has been a longstanding goal. We report…”
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The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse by Lagrue, Kathryn, Carisey, Alex, Oszmiana, Anna, Kennedy, Philippa R., Williamson, David J., Cartwright, Adam, Barthen, Charlotte, Davis, Daniel M.

“…Summary Natural killer (NK) cells discriminate between healthy and unhealthy target cells through a balance of activating and inhibitory signals at direct…”
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Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production by Dahlvang, James D, Dick, Jenna K, Sangala, Jules A, Kennedy, Philippa R, Pomeroy, Emily J, Snyder, Kristin M, Moushon, Juliette M, Thefaine, Claire E, Wu, Jianming, Hamilton, Sara E, Felices, Martin, Miller, Jeffrey S, Walcheck, Bruce, Webber, Beau R, Moriarity, Branden S, Hart, Geoffrey T

“…CMV infection alters NK cell phenotype and function toward a more memory-like immune state. These cells, termed adaptive NK cells, typically express CD57 and…”
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Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors by Kennedy, Philippa R, Barthen, Charlotte, Williamson, David J, Pitkeathly, William T E, Hazime, Khodor S, Cumming, Joshua, Stacey, Kevin B, Hilton, Hugo G, Carrington, Mary, Parham, Peter, Davis, Daniel M

“…Genetic diversity in human natural killer (NK) cell receptors is linked to resistance and susceptibility to many diseases. Here, we tested the effect of this…”
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Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments by Kennedy, Philippa R, Arvindam, Upasana Sunil, Phung, Shee Kwan, Ettestad, Brianna, Feng, Xueyang, Li, Yunmin, Kile, Quinlan M, Hinderlie, Peter, Khaw, Melissa, Huang, Rih-Sheng, Kaufman, Marissa, Puchalska, Patrycja, Russell, Amanda, Butler, Jonah, Abbott, Lucas, McClure, Paul, Luo, Xianghua, Lu, Quynhanh T, Blazar, Bruce R, Crawford, Peter A, Lim, James, Miller, Jeffrey S, Felices, Martin

“…Limited oxygen (hypoxia) in solid tumors poses a challenge to successful immunotherapy with natural killer (NK) cells. NK cells have impaired cytotoxicity when…”
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365 Oxygen levels found in bone marrow (5%) provide an optimal niche for the differentiation of induced-pluripotent stem cell-derived NK cells for the treatment of AML by Kennedy, Philippa R, Kile, Quinlan M, Waller, Rhett L, Bendzick, Laura, Selleck, Carly, Hinderlie, Peter, Kaufman, Marissa, Kodal, Behiye, Valamehr, Bahram, Miller, Jeffrey S, Felices, Martin

“…BackgroundAcute myeloid leukemia (AML) incidence increases with age. Five year survival for those over 65 is less than 11%, highlighting the need for safe…”
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1180 Maximizing NK cell immunotherapy in prostate cancer via TriKEs by Phung, Shee Kwan, Zorko, Nicholas, Shackelford, Madison, Bozicevich, Asha, Bendzick, Laura, Selleck, Carly, Soignier, Yvette, Nelson, Trygve, Walker, Joshua, Hinderlie, Peter, Kennedy, Philippa R, Miller, Jeffrey S, Felices, Martin

“…BackgroundNatural killer (NK) cells are being leveraged in the clinic due to their safety profile and their ability to mediate tumor killing without prior…”
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Ablation of SYK kinase from expanded primary human Natural Killer cells via CRISPR/Cas9 enhances cytotoxicity and cytokine production by Dahlvang, James D., Dick, Jenna K., Sangala, Jules A., Kennedy, Philippa R., Pomeroy, Emily J., Snyder, Kristin M., Moushon, Juliette M., Thefaine, Claire E., Wu, Jianming, Hamilton, Sara E., Felices, Martin, Miller, Jeffrey S., Walcheck, Bruce, Webber, Beau R., Moriarity, Branden S., Hart, Geoffrey T.

“…Cytomegalovirus (CMV) infection alters natural killer (NK) cell phenotype and function toward a more memory-like immune state. These cells, termed adaptive NK…”
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