Search Results - "Kennedy, Jacob"

Effect of deposition strategies on fatigue crack growth behaviour of wire + arc additive manufactured titanium alloy Ti–6Al–4V by Syed, Abdul Khadar, Zhang, Xiang, Davis, Alec E., Kennedy, Jacob R., Martina, Filomeno, Ding, Jialuo, Williams, Stewart, Prangnell, Philip B.

“…The influence of three deposition strategies on the fatigue crack growth behaviour of Wire + Arc Additive Manufactured (WAAM) Ti–6Al–4V has been investigated…”
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Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function by Salter, Alexander I, Rajan, Anusha, Kennedy, Jacob J, Ivey, Richard G, Shelby, Sarah A, Leung, Isabel, Templeton, Megan L, Muhunthan, Vishaka, Voillet, Valentin, Sommermeyer, Daniel, Whiteaker, Jeffrey R, Gottardo, Raphael, Veatch, Sarah L, Paulovich, Amanda G, Riddell, Stanley R

“…Chimeric antigen receptor (CAR)-modified T cell therapy is effective in treating lymphomas, leukemias, and multiple myeloma in which the tumor cells express…”
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Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins by Kennedy, Jacob J, Abbatiello, Susan E, Kim, Kyunggon, Yan, Ping, Whiteaker, Jeffrey R, Lin, Chenwei, Kim, Jun Seok, Zhang, Yuzheng, Wang, Xianlong, Ivey, Richard G, Zhao, Lei, Min, Hophil, Lee, Youngju, Yu, Myeong-Hee, Yang, Eun Gyeong, Lee, Cheolju, Wang, Pei, Rodriguez, Henry, Kim, Youngsoo, Carr, Steven A, Paulovich, Amanda G

“…This Analysis reports the development and assessment of 645 multiple reaction monitoring (MRM) mass spectrometry assays to quantify 319 targeted human breast…”
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Clinical Proteomics for Solid Organ Tissues by Phipps, William S., Kilgore, Mark R., Kennedy, Jacob J., Whiteaker, Jeffrey R., Hoofnagle, Andrew N., Paulovich, Amanda G.

“…The evaluation of biopsied solid organ tissue has long relied on visual examination using a microscope. Immunohistochemistry is critical in this process,…”
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The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans by Brandt, Cameron S, Baratin, Myriam, Yi, Eugene C, Kennedy, Jacob, Gao, Zeren, Fox, Brian, Haldeman, Betty, Ostrander, Craig D, Kaifu, Tomonori, Chabannon, Christian, Moretta, Alessandro, West, Robert, Xu, Wenfeng, Vivier, Eric, Levin, Steven D

“…Cancer development is often associated with the lack of specific and efficient recognition of tumor cells by the immune system. Natural killer (NK) cells are…”
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Quantification of Human Epidermal Growth Factor Receptor 2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded and Frozen Breast Cancer Tissues by Kennedy, Jacob J, Whiteaker, Jeffrey R, Kennedy, Laura C, Bosch, Dustin E, Lerch, Melissa L, Schoenherr, Regine M, Zhao, Lei, Lin, ChenWei, Chowdhury, Shrabanti, Kilgore, Mark R, Allison, Kimberly H, Wang, Pei, Hoofnagle, Andrew N, Baird, Geoffrey Stuart, Paulovich, Amanda G

“…Abstract Background Conventional HER2-targeting therapies improve outcomes for patients with HER2-positive breast cancer (BC), defined as tumors showing HER2…”
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CDK5–cyclin B1 regulates mitotic fidelity by Zheng, Xiao-Feng, Sarkar, Aniruddha, Lotana, Humphrey, Syed, Aleem, Nguyen, Huy, Ivey, Richard G., Kennedy, Jacob J., Whiteaker, Jeffrey R., Tomasik, Bartłomiej, Huang, Kaimeng, Li, Feng, D’Andrea, Alan D., Paulovich, Amanda G., Shah, Kavita, Spektor, Alexander, Chowdhury, Dipanjan

“…CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression 1 . Here we demonstrate that CDK5 is active…”
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Optimized Protocol for Quantitative Multiple Reaction Monitoring-Based Proteomic Analysis of Formalin-Fixed, Paraffin-Embedded Tissues by Kennedy, Jacob J, Whiteaker, Jeffrey R, Schoenherr, Regine M, Yan, Ping, Allison, Kimberly, Shipley, Melissa, Lerch, Melissa, Hoofnagle, Andrew N, Baird, Geoffrey Stuart, Paulovich, Amanda G

“…Despite a clinical, economic, and regulatory imperative to develop companion diagnostics, precious few new biomarkers have been successfully translated into…”
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A targeted proteomics-based pipeline for verification of biomarkers in plasma by Paulovich, Amanda G, Whiteaker, Jeffrey R, Lin, Chenwei, Kennedy, Jacob, Hou, Liming, Trute, Mary, Sokal, Izabela, Yan, Ping, Schoenherr, Regine M, Zhao, Lei, Voytovich, Uliana J, Kelly-Spratt, Karen S, Krasnoselsky, Alexei, Gafken, Philip R, Hogan, Jason M, Jones, Lisa A, Wang, Pei, Amon, Lynn, Chodosh, Lewis A, Nelson, Peter S, McIntosh, Martin W, Kemp, Christopher J

“…Prioritizing candidate biomarkers for verification remains a formidable obstacle to the translation of protein diagnostics to clinical applications. Whiteaker…”
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Effect of Machine Hammer Peening Conditions on β Grain Refinement of Additively Manufactured Ti-6Al-4V by Neto, Leonor, Williams, Stewart, Davis, Alec E., Kennedy, Jacob R.

“…Ti-6Al-4V components built with wire plus arc additive manufacturing (WAAM) generally have long columnar β grains that cause anisotropic behavior when the…”
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Microsegregation Model Including Convection and Tip Undercooling: Application to Directional Solidification and Welding by Billotte, Thomas, Daloz, Dominique, Rouat, Bernard, Tirand, Guillaume, Kennedy, Jacob R, Robin, Vincent, Zollinger, Julien

“…The microsegregation behavior of alloy filler metal 52 (FM 52) was studied using microprobe analysis on two different solidification processes. First,…”
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Monitoring Both Extended and Tryptic Forms of Stable Isotope-Labeled Standard Peptides Provides an Internal Quality Control of Proteolytic Digestion in Targeted Mass Spectrometry-Based Assays by Lundeen, Rachel A., Kennedy, Jacob J., Murillo, Oscar D., Ivey, Richard G., Zhao, Lei, Schoenherr, Regine M., Hoofnagle, Andrew N., Wang, Pei, Whiteaker, Jeffrey R., Paulovich, Amanda G.

“…Targeted mass spectrometry (MS)-based proteomic assays, such as multiplexed multiple reaction monitoring (MRM)-MS assays, enable sensitive and specific…”
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Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer by Chowdhury, Shrabanti, Kennedy, Jacob J., Ivey, Richard G., Murillo, Oscar D., Hosseini, Noshad, Song, Xiaoyu, Petralia, Francesca, Calinawan, Anna, Savage, Sara R., Berry, Anna B., Reva, Boris, Ozbek, Umut, Krek, Azra, Ma, Weiping, da Veiga Leprevost, Felipe, Ji, Jiayi, Yoo, Seungyeul, Lin, Chenwei, Voytovich, Uliana J., Huang, Yajue, Lee, Sun-Hee, Bergan, Lindsay, Lorentzen, Travis D., Mesri, Mehdi, Rodriguez, Henry, Hoofnagle, Andrew N., Herbert, Zachary T., Nesvizhskii, Alexey I., Zhang, Bing, Whiteaker, Jeffrey R., Fenyo, David, McKerrow, Wilson, Wang, Joshua, Schürer, Stephan C., Stathias, Vasileios, Chen, X. Steven, Barcellos-Hoff, Mary Helen, Starr, Timothy K., Winterhoff, Boris J., Nelson, Andrew C., Mok, Samuel C., Kaufmann, Scott H., Drescher, Charles, Cieslik, Marcin, Wang, Pei, Birrer, Michael J., Paulovich, Amanda G.

“…To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory…”
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Immobilized Metal Affinity Chromatography Coupled to Multiple Reaction Monitoring Enables Reproducible Quantification of Phospho-signaling by Kennedy, Jacob J., Yan, Ping, Zhao, Lei, Ivey, Richard G., Voytovich, Uliana J., Moore, Heather D., Lin, Chenwei, Pogosova-Agadjanyan, Era L., Stirewalt, Derek L., Reding, Kerryn W., Whiteaker, Jeffrey R., Paulovich, Amanda G.

“…A major goal in cell signaling research is the quantification of phosphorylation pharmacodynamics following perturbations. Traditional methods of studying…”
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CPTAC Assay Portal: a repository of targeted proteomic assays by Whiteaker, Jeffrey R, Halusa, Goran N, Hoofnagle, Andrew N, Sharma, Vagisha, MacLean, Brendan, Yan, Ping, Wrobel, John A, Kennedy, Jacob, Mani, D R, Zimmerman, Lisa J, Meyer, Matthew R, Mesri, Mehdi, Rodriguez, Henry, Paulovich, Amanda G

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Internal Standard Triggered-Parallel Reaction Monitoring Mass Spectrometry Enables Multiplexed Quantification of Candidate Biomarkers in Plasma by Kennedy, Jacob J., Whiteaker, Jeffrey R., Ivey, Richard G., Burian, Aura, Chowdhury, Shrabanti, Tsai, Chia-Feng, Liu, Tao, Lin, ChenWei, Murillo, Oscar D., Lundeen, Rachel A., Jones, Lisa A., Gafken, Philip R., Longton, Gary, Rodland, Karin D., Skates, Steven J., Landua, John, Wang, Pei, Lewis, Michael T., Paulovich, Amanda G.

“…Despite advances in proteomic technologies, clinical translation of plasma biomarkers remains low, partly due to a major bottleneck between the discovery of…”
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RNA and phosphoprotein profiles of TP53- and PTEN-knockouts in MCF10A at baseline and responding to DNA damage by Lin, ChenWei, Schoenherr, Regine M., Voytovich, Uliana J., Ivey, Richard G., Kennedy, Jacob J., Whiteaker, Jeffrey R., Wang, Pei, Paulovich, Amanda G.

“…A wealth of proteogenomic data has been generated using cancer samples to deepen our understanding of the mechanisms of cancer and how biological networks are…”
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Effect of Inoculant Alloy Selection and Particle Size on Efficiency of Isomorphic Inoculation of Ti-Al by Kennedy, J R, Rouat, B, Daloz, D, Bouzy, E, Zollinger, J

“…The process of isomorphic inoculation relies on precise selection of inoculant alloys for a given system. Three alloys, Ti-10Al-25Nb, Ti-25Al-10Ta, and Ti-47Ta…”
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Carbohydrate Characterization through Multidimensional NMR: An Undergraduate Organic Laboratory Experiment by Kennedy, Jacob S, Larson, Garrett E, Blumenfeld, Alex, Waynant, Kristopher V

“…Carbohydrates are an essential group of molecules to the organic chemistry classroom providing molecular relevance to a common ingredient in chemical biology…”
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Targeted Mass Spectrometry for Quantification of Receptor Tyrosine Kinase Signaling by Whiteaker, Jeffrey R, Zhao, Lei, Kennedy, Jacob J, Ivey, Richard G, Paulovich, Amanda G

“…Targeted proteomics enables sensitive and specific quantification of proteins and post-translational modifications. By coupling peptide immunoaffinity…”
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