Search Results - "Kennedy, Edward M."

Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication by Courtney, David G., Kennedy, Edward M., Dumm, Rebekah E., Bogerd, Hal P., Tsai, Kevin, Heaton, Nicholas S., Cullen, Bryan R.

“…Many viral RNAs are modified by methylation of the N6 position of adenosine (m6A). m6A is thought to regulate RNA splicing, stability, translation, and…”
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Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease by Kennedy, Edward M, Kornepati, Anand V R, Goldstein, Michael, Bogerd, Hal P, Poling, Brigid C, Whisnant, Adam W, Kastan, Michael B, Cullen, Bryan R

“…High-risk human papillomaviruses (HPVs), including HPV-16 and HPV-18, are the causative agents of cervical carcinomas and are linked to several other tumors of…”
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Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications by Friedland, Ari E, Baral, Reshica, Singhal, Pankhuri, Loveluck, Katherine, Shen, Shen, Sanchez, Minerva, Marco, Eugenio, Gotta, Gregory M, Maeder, Morgan L, Kennedy, Edward M, Kornepati, Anand V R, Sousa, Alexander, Collins, McKensie A, Jayaram, Hari, Cullen, Bryan R, Bumcrot, David

“…CRISPR-Cas systems have been broadly embraced as effective tools for genome engineering applications, with most studies to date utilizing the Streptococcus…”
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Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease by Kennedy, Edward M, Bassit, Leda C, Mueller, Henrik, Kornepati, Anand V.R, Bogerd, Hal P, Nie, Ting, Chatterjee, Payel, Javanbakht, Hassan, Schinazi, Raymond F, Cullen, Bryan R

“…Abstract Hepatitis B virus (HBV) remains a major human pathogen, with over 240 million individuals suffering from chronic HBV infections. These can persist for…”
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Viral Epitranscriptomics by Kennedy, Edward M, Courtney, David G, Tsai, Kevin, Cullen, Bryan R

“…Although it has been known for over 40 years that eukaryotic mRNAs bear internal base modifications, it is only in the last 5 years that the importance of…”
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A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor by Heaton, Brook E., Kennedy, Edward M., Dumm, Rebekah E., Harding, Alfred T., Sacco, Matthew T., Sachs, David, Heaton, Nicholas S.

“…Influenza A virus (IAV) is a pathogen that poses significant risks to human health. It is therefore critical to develop strategies to prevent influenza…”
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Gene Editing: A New Tool for Viral Disease by Kennedy, Edward M, Cullen, Bryan R

“…The emergence of the CRISPR Cas system of antiviral adaptive immunity in bacteria as a facile system for gene editing in mammalian cells may well lead to gene…”
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Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression by Courtney, David G, Chalem, Andrea, Bogerd, Hal P, Law, Brittany A, Kennedy, Edward M, Holley, Christopher L, Cullen, Bryan R

“…While it has been known for several years that viral RNAs are subject to the addition of several distinct covalent modifications to individual nucleotides,…”
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Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs by Bogerd, Hal P, Skalsky, Rebecca L, Kennedy, Edward M, Furuse, Yuki, Whisnant, Adam W, Flores, Omar, Schultz, Kimberly L W, Putnam, Nicole, Barrows, Nicholas J, Sherry, Barbara, Scholle, Frank, Garcia-Blanco, Mariano A, Griffin, Diane E, Cullen, Bryan R

“…The issue of whether viruses are subject to restriction by endogenous microRNAs (miRNAs) and/or by virus-induced small interfering RNAs (siRNAs) in infected…”
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Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer by Kennedy, Edward M., Whisnant, Adam W., Kornepati, Anand V. R., Marshall, Joy B., Bogerd, Hal P., Cullen, Bryan R.

“…Although RNA interference (RNAi) functions as a potent antiviral innate-immune response in plants and invertebrates, mammalian somatic cells appear incapable…”
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Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk by Galarza-Muñoz, Gaddiel, Briggs, Farren B.S., Evsyukova, Irina, Schott-Lerner, Geraldine, Kennedy, Edward M., Nyanhete, Tinashe, Wang, Liuyang, Bergamaschi, Laura, Widen, Steven G., Tomaras, Georgia D., Ko, Dennis C., Bradrick, Shelton S., Barcellos, Lisa F., Gregory, Simon G., Garcia-Blanco, Mariano A.

“…Multiple sclerosis (MS) is an autoimmune disorder where T cells attack neurons in the central nervous system (CNS) leading to demyelination and neurological…”
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Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer by Kennedy, Edward M., Denslow, Agnieszka, Hewett, Jacqueline, Kong, Lingxin, De Almeida, Ana, Bryant, Jeffrey D., Lee, Jennifer S., Jacques, Judy, Feau, Sonia, Hayes, Melissa, McMichael, Elizabeth L., Wambua, Daniel, Farkaly, Terry, Rahmeh, Amal A, Herschelman, Lauren, Douglas, Danielle, Spinale, Jacob, Adhikari, Sanmit, Deterling, Jessica, Scott, Matt, Haines, Brian B., Finer, Mitchell H., Ashburn, Ted T, Quéva, Christophe, Lerner, Lorena

“…The therapeutic effectiveness of oncolytic viruses (OVs) delivered intravenously is limited by the development of neutralizing antibody responses against the…”
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Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing by Tsai, Kevin, Bogerd, Hal P, Kennedy, Edward M, Emery, Ann, Swanstrom, Ronald, Cullen, Bryan R

“…In this study, Tsai et al. set out to study how cellular m 6 A recognition proteins regulate HIV gene expression. Using genetic and genomic approaches, the…”
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Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators by Bogerd, Hal P., Kornepati, Anand V. R., Marshall, Joy B., Kennedy, Edward M., Cullen, Bryan R.

“…Whereas several mammalian proteins can restrict the replication of HIV-1 and other viruses, these are often not expressed in relevant target cells. A potential…”
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Expression of CRISPR/Cas single guide RNAs using small tRNA promoters by Mefferd, Adam L, Kornepati, Anand V R, Bogerd, Hal P, Kennedy, Edward M, Cullen, Bryan R

“…The in vivo application of CRISPR/Cas-based DNA editing technology will require the development of efficient delivery methods that likely will be dependent on…”
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Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages by Kennedy, Edward M., Gavegnano, Christina, Nguyen, Laura, Slater, Rebecca, Lucas, Amanda, Fromentin, Emilie, Schinazi, Raymond F., Kim, Baek

“…We biochemically simulated HIV-1 DNA polymerization in physiological nucleotide pools found in two HIV-1 target cell types: terminally…”
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N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection by Gokhale, Nandan S., McIntyre, Alexa B.R., McFadden, Michael J., Roder, Allison E., Kennedy, Edward M., Gandara, Jorge A., Hopcraft, Sharon E., Quicke, Kendra M., Vazquez, Christine, Willer, Jason, Ilkayeva, Olga R., Law, Brittany A., Holley, Christopher L., Garcia-Blanco, Mariano A., Evans, Matthew J., Suthar, Mehul S., Bradrick, Shelton S., Mason, Christopher E., Horner, Stacy M.

“…The RNA modification N6-methyladenosine (m6A) post-transcriptionally regulates RNA function. The cellular machinery that controls m6A includes…”
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Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression by Courtney, David G., Tsai, Kevin, Bogerd, Hal P., Kennedy, Edward M., Law, Brittany A., Emery, Ann, Swanstrom, Ronald, Holley, Christopher L., Cullen, Bryan R.

“…How the covalent modification of mRNA ribonucleotides, termed epitranscriptomic modifications, alters mRNA function remains unclear. One issue has been the…”
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Induced Packaging of Cellular MicroRNAs into HIV-1 Virions Can Inhibit Infectivity by Bogerd, Hal P, Kennedy, Edward M, Whisnant, Adam W, Cullen, Bryan R

“…Analysis of the incorporation of cellular microRNAs (miRNAs) into highly purified HIV-1 virions revealed that this largely, but not entirely, mirrored the…”
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Seneca Valley virus replicons are packaged in trans and have the capacity to overcome the limitations of viral transgene expression by Bryant, Jeffrey D., Lee, Jennifer S., De Almeida, Ana, Jacques, Judy, Chang, Ching-Hung, Fassler, William, Quéva, Christophe, Lerner, Lorena, Kennedy, Edward M.

“…Oncolytic viruses (OVs) promote the anti-tumor immune response as their replication, and the subsequent lysis of tumor cells, triggers the activation of…”
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