Search Results - "Kennedy, Domenick E"

Inhibition of B Lymphopoiesis by Adipocytes and IL-1-Producing Myeloid-Derived Suppressor Cells by Kennedy, Domenick E, Knight, Katherine L

“…B lymphopoiesis declines with age, and this decline correlates with increased adipose tissue in the bone marrow (BM). Also, adipocyte-derived factors are known…”
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Novel specialized cell state and spatial compartments within the germinal center by Kennedy, Domenick E., Okoreeh, Michael K., Maienschein-Cline, Mark, Ai, Junting, Veselits, Margaret, McLean, Kaitlin C., Dhungana, Yogesh, Wang, Hong, Peng, Junmin, Chi, Hongbo, Mandal, Malay, Clark, Marcus R.

“…Within germinal centers (GCs), complex and highly orchestrated molecular programs must balance proliferation, somatic hypermutation and selection to both…”
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Compartments and Connections Within the Germinal Center by Kennedy, Domenick E, Clark, Marcus R

“…Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been…”
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BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis by Mandal, Malay, Maienschein-Cline, Mark, Maffucci, Patrick, Veselits, Margaret, Kennedy, Domenick E., McLean, Kaitlin C., Okoreeh, Michael K., Karki, Sophiya, Cunningham-Rundles, Charlotte, Clark, Marcus R.

“…Transcription factor (TF) networks determine cell fate in hematopoiesis. However, how TFs cooperate with other regulatory mechanisms to instruct transcription…”
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Bone marrow fat and the decline of B lymphopoiesis in rabbits by Kennedy, Domenick E., Witte, Pamela L., Knight, Katherine L.

“…B lymphopoiesis is necessary to generate a diverse pool of naïve B cells that are able to respond to a broad spectrum of antigens during immune responses to…”
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IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses by Camacho, Daniel F, Velez, Tania E, Hollinger, Maile K, Wang, Esther, Howard, Chanie L, Darnell, Eli P, Kennedy, Domenick E, Krishack, Paulette A, Hrusch, Cara L, Clark, Marcus R, Moon, James J, Sperling, Anne I

“…Expression of the transcription factor interferon regulatory factor 4 (IRF4) is required for the development of lung conventional DCs type 2 (cDC2s) that…”
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Inflammatory Changes in Bone Marrow Microenvironment Associated with Declining B Lymphopoiesis by Kennedy, Domenick E, Knight, Katherine L

“…B lymphopoiesis arrests precipitously in rabbits such that by 2-4 mo of age, before sexual maturity, little to no B lymphopoiesis occurs in the bone marrow…”
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CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis by Mandal, Malay, Okoreeh, Michael K., Kennedy, Domenick E., Maienschein-Cline, Mark, Ai, Junting, McLean, Kaitlin C., Kaverina, Natalya, Veselits, Margaret, Aifantis, Iannis, Gounari, Fotini, Clark, Marcus R.

“…In B lymphopoiesis, activation of the pre-B cell antigen receptor (pre-BCR) is associated with both cell cycle exit and Igk recombination. Yet how the pre-BCR…”
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PI3Kδ: Too much of a good thing by Kennedy, Domenick E., Clark, Marcus R.

“…PI3Kδ regulates adaptive immune thresholds and limits immunity to endogenous microbiota…”
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The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state by Lee, Victoria, Rodriguez, Donald M., Ganci, Nicole K., Zeng, Sharon, Ai, Junting, Chao, Jaime L., Walker, Matthew T., Miller, Christine H., Klawon, David E. J., Schoenbach, Mary H., Kennedy, Domenick E., Maienschein-Cline, Mark, Socci, Nicholas D., Clark, Marcus R., Savage, Peter A.

“…The T cell repertoire of healthy mice and humans harbors self-reactive CD4 + conventional T (T conv ) cells capable of inducing autoimmunity. Using T cell…”
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Regulated Capture of Vκ Gene Topologically Associating Domains by Transcription Factories by Karki, Sophiya, Kennedy, Domenick E., Mclean, Kaitlin, Grzybowski, Adrian T., Maienschein-Cline, Mark, Banerjee, Shiladitya, Xu, Heping, Davis, Elizabeth, Mandal, Malay, Labno, Christine, Powers, Sarah E., Le Beau, Michelle M., Dinner, Aaron R., Singh, Harinder, Ruthenburg, Alexander J., Clark, Marcus R.

“…Expression of vast repertoires of antigen receptors by lymphocytes, with each cell expressing a single receptor, requires stochastic activation of individual…”
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Withdrawn: Bone marrow fat and the decline of B lymphopoiesis in rabbits by Kennedy, Domenick E., Witte, Pamela L., Knight, Katherine L.

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Asymmetrical forward and reverse developmental trajectories determine molecular programs of B cell antigen receptor editing by Okoreeh, Michael K, Kennedy, Domenick E, Emmanuel, Akinola Olumide, Veselits, Margaret, Moshin, Azam, Ladd, Robert H, Erickson, Steven, McLean, Kaitlin C, Madrigal, Brianna, Nemazee, David, Maienschein-Cline, Mark, Mandal, Malay, Clark, Marcus R

“…During B lymphopoiesis, B cell progenitors progress through alternating and mutually exclusive stages of clonal expansion and immunoglobulin (Ig) gene…”
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PI3K[delta]: Too much of a good thing by Kennedy, Domenick E, Clark, Marcus R

“…PI3K[delta] regulates adaptive immune thresholds and limits immunity to endogenous microbiota…”
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Inflammatory changes in bone marrow microenvironment associated with declining B lymphopoiesis1 by Kennedy, Domenick E., Knight, Katherine L.

“…B lymphopoiesis arrests precipitously in rabbits such that by 2 to 4 months of age, prior to sexual maturity, little to no B lymphopoiesis occurs in the bone…”
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Inhibition of B-lymphopoiesis by Adipocytes and IL-1-producing MDSCs1 by Kennedy, Domenick E., Knight, Katherine L.

“…B-lymphopoiesis declines with age, and this decline not only correlates with increased adipose tissue in the bone marrow (BM), but also adipocyte-derived…”
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