Search Results - "Kennedy, Christopher R."

Urinary Podocyte Microparticles Identify Prealbuminuric Diabetic Glomerular Injury by BURGER, Dylan, THIBODEAU, Jean-Francois, HOLTERMAN, Chet E, BURNS, Kevin D, TOUYZ, Rhian M, KENNEDY, Christopher R. J

“…Microparticles (MPs) are small (0.1-1.0 µm) vesicles shed from the surface of cells in response to stress. Whether podocytes produce MPs and whether this…”
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Assessment of urinary microparticles in normotensive patients with type 1 diabetes by Lytvyn, Yuliya, Xiao, Fengxia, Kennedy, Christopher R. J., Perkins, Bruce A., Reich, Heather N., Scholey, James W., Cherney, David Z., Burger, Dylan

“…Aims/hypothesis Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of…”
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The Proteome of Circulating Large Extracellular Vesicles in Diabetes and Hypertension by Abolbaghaei, Akram, Turner, Maddison, Thibodeau, Jean-François, Holterman, Chet E, Kennedy, Christopher R J, Burger, Dylan

“…Hypertension and diabetes induce vascular injury through processes that are not fully understood. Changes in extracellular vesicle (EV) composition could…”
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Nephropathy and Elevated BP in Mice with Podocyte-Specific NADPH Oxidase 5 Expression by HOLTERMAN, Chet E, THIBODEAU, Jean-François, TOWAIJ, Chelsea, GUTSOL, Alex, MONTEZANO, Augusto C, PARKS, Robin J, COOPER, Mark E, TOUYZ, Rhian M, KENNEDY, Christopher R. J

“…NADPH oxidase (Nox) enzymes are a significant source of reactive oxygen species, which contribute to glomerular podocyte dysfunction. Although studies have…”
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High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury by Cheff, Véronique, Trentin-Sonoda, Mayra, Blais, Amélie, Thibodeau, Jean-François, Holterman, Chet E, Gutsol, Alex, Kennedy, Christopher R J, Hébert, Richard L

“…Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of…”
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Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36 by Munkonda, Mercedes N., Akbari, Shareef, Landry, Chloe, Sun, Suzy, Xiao, Fengxia, Turner, Maddison, Holterman, Chet E., Nasrallah, Rania, Hébert, Richard L., Kennedy, Christopher R. J., Burger, Dylan

“…Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms…”
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A novel mouse model of advanced diabetic kidney disease by Thibodeau, Jean-Francois, Holterman, Chet E, Burger, Dylan, Read, Naomi C, Reudelhuber, Timothy L, Kennedy, Christopher R J

“…Currently available rodent models exhibit characteristics of early diabetic nephropathy (DN) such as hyperfiltration, mesangial expansion, and albuminuria yet…”
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Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease by Simard, Jean-Christophe, Thibodeau, Jean-François, Leduc, Martin, Tremblay, Mikael, Laverdure, Alexandre, Sarra-Bournet, François, Gagnon, William, Ouboudinar, Jugurtha, Gervais, Liette, Felton, Alexandra, Letourneau, Sylvie, Geerts, Lilianne, Cloutier, Marie-Pier, Hince, Kathy, Corpuz, Ramon, Blais, Alexandra, Quintela, Vanessa Marques, Duceppe, Jean-Simon, Abbott, Shaun D., Blais, Amélie, Zacharie, Boulos, Laurin, Pierre, Laplante, Steven R., Kennedy, Christopher R. J., Hébert, Richard L., Leblond, François A., Grouix, Brigitte, Gagnon, Lyne

“…Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease and is associated with metabolic dysregulation. Although G protein-coupled…”
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Endothelial NOX5 Obliterates the Reno-Protective Effect of Nox4 Deletion by Promoting Renal Fibrosis via Activation of EMT and ROS-Sensitive Pathways in Diabetes by Jandeleit-Dahm, Karin A M, Kankanamalage, Haritha R, Dai, Aozhi, Meister, Jaroslawna, Lopez-Trevino, Sara, Cooper, Mark E, Touyz, Rhian M, Kennedy, Christopher R J, Jha, Jay C

“…Chronic hyperglycemia induces intrarenal oxidative stress due to the excessive production of reactive oxygen species (ROS), leading to a cascade of events that…”
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Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions by Cuerrier, Charles M, Chen, Yong-Xiang, Tremblay, Dominique, Rayner, Katey, McNulty, Melissa, Zhao, XiaoLing, Kennedy, Christopher R J, de BelleRoche, Jacqueline, Pelling, Andrew E, O'Brien, Edward R

“…Expression of Heat Shock Protein-27 (HSP27) is reduced in human coronary atherosclerosis. Over-expression of HSP27 is protective against the early formation of…”
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Gender differences in the renal response to renin- angiotensin system blockade by MILLER, Judith A, CHERNEY, David Z, DUNCAN, John A, LAI, Vesta, BURNS, Kevin D, KENNEDY, Christopher R. J, ZIMPELMANN, Joseph, WEI GAO, CATTRAN, Daniel C, SCHOLEY, James W

“…Evidence suggests that gender differences exist in renin-angiotensin system (RAS) function. It was hypothesized that women may differ also in their response to…”
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A Maladaptive Role for EP4 Receptors in Podocytes by STITT-CAVANAGH, Erin M, FAOUR, Wissam H, TAKAMI, Kaede, CARTER, Anthony, VANDERHYDEN, Barbara, YOUFEI GUAN, SCHNEIDER, Andre, BREYER, Matthew D, KENNEDY, Christopher R. J

“…Inhibition of p38 mitogen-activated protein kinase and cyclooxygenase-2 reduces albuminuria in models of chronic kidney disease marked by podocyte injury…”
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Advancing Discovery Research in Nephrology in Canada: A Conference Report From the 2021 Molecules and Mechanisms Mediating Kidney Health and Disease (M3K) Scientific Meeting and Investigator Summit by Burger, Dylan, Abdelrasoul, Amira, Alexander, R. Todd, Ballermann, Barbara, Bridgewater, Darren, Chan, John S. D., Cunanan, Joanna, Cybulsky, Andrey V., Gerarduzzi, Casimiro, Gunaratnam, Lakshman, Hartwig, Sunny, Kapus, Andras, Kennedy, Christopher R. J., Lamarche, Caroline, Myette, Robert L., Nmecha, Ifeanyi Kennedy, Stalker, Leanne, Szaszi, Katalin, Torban, Elena, Zhang, Shao Ling, Takano, Tomoko

“…Purpose of conference: New discoveries arising from investigations into fundamental aspects of kidney development and function in health and disease are…”
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Vascular Smooth Muscle-Specific EP4 Receptor Deletion in Mice Exacerbates Angiotensin II-Induced Renal Injury by Thibodeau, Jean-Francois, Holterman, Chet E, He, Ying, Carter, Anthony, Cron, Gregory O, Boisvert, Naomi C, Abd-Elrahman, Khaled S, Hsu, Karolynn J, Ferguson, Stephen S G, Kennedy, Christopher R J

“…Cyclooxygenase inhibition by non-steroidal anti-inflammatory drugs is contraindicated in hypertension, as it may reduce glomerular filtration rate (GFR) and…”
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Urinary podocyte-derived large extracellular vesicles are increased in paediatric idiopathic nephrotic syndrome by Myette, Robert L, Xiao, Fengxia, Geier, Pavel, Feber, Janusz, Burger, Dylan, Kennedy, Christopher R J

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Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy by Deliyanti, Devy, Alrashdi, Saeed F., Touyz, Rhian M., Kennedy, Christopher R., Jha, Jay C., Cooper, Mark E., Jandeleit-Dahm, Karin A., Wilkinson-Berka, Jennifer L.

“…Hypertension is a risk factor for the vascular permeability and neovascularization that threatens vision in diabetic retinopathy. Excess reactive oxygen…”
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Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice by Ouellette, Julie, Toussay, Xavier, Comin, Cesar H., Costa, Luciano da F., Ho, Mirabelle, Lacalle-Aurioles, María, Freitas-Andrade, Moises, Liu, Qing Yan, Leclerc, Sonia, Pan, Youlian, Liu, Ziying, Thibodeau, Jean-François, Yin, Melissa, Carrier, Micael, Morse, Cameron J., Dyken, Peter Van, Bergin, Christopher J., Baillet, Sylvain, Kennedy, Christopher R., Tremblay, Marie-Ève, Benoit, Yannick D., Stanford, William L., Burger, Dylan, Stewart, Duncan J., Lacoste, Baptiste

“…While the neuronal underpinnings of autism spectrum disorder (ASD) are being unraveled, vascular contributions to ASD remain elusive. Here, we investigated…”
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A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84 by Gagnon, Lyne, Leduc, Martin, Thibodeau, Jean-Francois, Zhang, Ming-Zhi, Grouix, Brigitte, Sarra-Bournet, Francois, Gagnon, William, Hince, Kathy, Tremblay, Mikaël, Geerts, Lilianne, Kennedy, Christopher R J, Hébert, Richard L, Gutsol, Alex, Holterman, Chet E, Kamto, Eldjonai, Gervais, Liette, Ouboudinar, Jugurtha, Richard, Jonathan, Felton, Alexandra, Laverdure, Alexandre, Simard, Jean-Christophe, Létourneau, Sylvie, Cloutier, Marie-Pier, Leblond, Francois A, Abbott, Shaun D, Penney, Christopher, Duceppe, Jean-Simon, Zacharie, Boulos, Dupuis, Jocelyn, Calderone, Angelino, Nguyen, Quang T, Harris, Raymond C, Laurin, Pierre

“…Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target…”
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Septic pericardial disease and mediastinal abscessation in a cat with an intrathoracic needle foreign body by Bahlmann, Kaitlin N., Kennedy, Christopher R., Bandt, Carsten

“…Objective To describe the successful management of a cat with an intrathoracic sewing needle foreign body and septic pericardial effusion. Case Summary A…”
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Left atrial measurement in lateral versus sternal recumbency in cats undergoing focused cardiac ultrasound examination by Burnotte, Priscilla, Gommeren, Kris, Kennedy, Christopher R., Boysen, Søren R., Merveille, Anne-Christine

“…Objective To compare left atrial measurements carried out by an emergency and critical care (ECC) clinician on cats in lateral and sternal recumbency. Animals…”
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