Search Results - "Kennard, John A."

Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice by Mi, Deborah J., Dixit, Shilpy, Warner, Timothy A., Kennard, John A., Scharf, Daniel A., Kessler, Eric S., Moore, Lisa M., Consoli, David C., Bown, Corey W., Eugene, Angeline J., Kang, Jing-Qiong, Harrison, Fiona E.

“…Ascorbate (vitamin C) is critical as a first line of defense antioxidant within the brain, and specifically within the synapse. Ascorbate is released by…”
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Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease by Warner, Timothy A, Kang, Jing-Qiong, Kennard, John A, Harrison, Fiona E

“…Highlights • Ascorbic acid deficiency shortened latency to onset of kainic acid-induced seizures. • APP/PSEN1 mutations shortened latency to onset of kainic…”
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A comparison of low- and high-impact forced exercise: Effects of training paradigm on learning and memory by Kennard, John A, Woodruff-Pak, Diana S

“…Abstract In this study we compared two types of forced exercise—a low impact paradigm to minimize stress, which included speeds up to 10 m/min and a stressful…”
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Differential effects and rates of normal aging in cerebellum and hippocampus by Woodruff-Pak, Diana S, Foy, Michael R, Akopian, Garnik G, Lee, Ka Hung, Zach, Jordan, Nguyen, Kim Phuong Thi, Comalli, David M, Kennard, John A, Agelan, Alexis, Thompson, Richard F

“…Cognitive functions show many alternative outcomes and great individual variation during normal aging. We examined learning over the adult life span in CBA…”
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Age sensitivity of behavioral tests and brain substrates of normal aging in mice by Kennard, John A, Woodruff-Pak, Diana S

“…Knowledge of age sensitivity, the capacity of a behavioral test to reliably detect age-related changes, has utility in the design of experiments to elucidate…”
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Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice by Kennard, John A., Harrison, Fiona E.

“…•Time course of ASC uptake varied among organs in ASC-depleted mice following IV ASC.•IV ASC improved short-term spatial memory in middle-aged APP/PSEN1 and WT…”
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The context preexposure facilitation effect in mice: A dose–response analysis of pretraining scopolamine administration by Brown, Kevin L., Kennard, John A., Sherer, Daniel J., Comalli, David M., Woodruff-Pak, Diana S.

“…► We compare two versions of the context preexposure facilitation effect in mice. ► A hippocampal-sensitive CPFE was successfully adapted to mice (Experiment…”
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Aging in the cerebellum and hippocampus and associated behaviors over the adult life span of CB6F1 mice by Kennard, J.A, Brown, K.L, Woodruff-Pak, D.S

“…Highlights • Compared age effects on hippocampus- and cerebellum-dependent learning in mice. • Tasks were chosen to increase the ability to detect age-related…”
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Age sensitivity of the Barnes maze and the Morris water maze: Associations with cerebellar cortical Purkinje neurons by Kennard, John A

“…The goal of this study was to examine age-related changes in spatial memory and its neurobiological substrates as assessed by the Morris water maze (MWM) and…”
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