Search Results - "Kenmogne, Lucie Carolle"

Two androsterone derivatives as inhibitors of androgen biosynthesis by Djigoue, Guy-Bertrand, Simard, Michel, Kenmogne, Lucie-Carolle, Poirier, Donald

“…The title compounds,…”
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The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers by Kenmogne, Lucie Carolle, Ayan, Diana, Roy, Jenny, Maltais, René, Poirier, Donald

“…Ovarian and pancreatic cancers are two of the most aggressive and lethal cancers, whose management faces only limited therapeutic options. Typically, these…”
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Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models by Kenmogne, Lucie Carolle, Roy, Jenny, Maltais, René, Rouleau, Mélanie, Neveu, Bertrand, Pouliot, Frédéric, Poirier, Donald

“…In the fight against androgen-sensitive prostate cancer, the enzyme 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is an attractive therapeutic target…”
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Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imaging by Kenmogne, Lucie Carolle, Maltais, René, Poirier, Donald

“…[Display omitted] The steroidogenic enzyme 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is a therapeutic target in the management of androgen-sensitive…”
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Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3 by Djigoué, Guy Bertrand, Kenmogne, Lucie Carolle, Roy, Jenny, Maltais, René, Poirier, Donald

“…[Display omitted] 17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3) is a key enzyme involved in the biosynthesis of testosterone and dihydrotestosterone…”
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Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133 by Perreault, Martin, Maltais, René, Kenmogne, Lucie Carolle, Létourneau, Danny, LeHoux, Jean-Guy, Gobeil, Stéphane, Poirier, Donald

“…[Display omitted] The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse…”
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Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents by Talbot, Amélie, Maltais, René, Kenmogne, Lucie Carolle, Roy, Jenny, Poirier, Donald

“…[Display omitted] •Libraries of hydroxy-acetylenic steroid derivatives were prepared.•The usefulness of a diethylsilyl acetylenic linker for solid-phase…”
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Synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3 by Djigoué, Guy Bertrand, Kenmogne, Lucie Carolle, Roy, Jenny, Poirier, Donald

“…Spiromorpholinone derivatives were synthesized from androsterone or cyclohexanone in 6 or 3 steps, respectively, and these scaffolds were used for the…”
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Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17[beta]-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models by Kenmogne, Lucie Carolle, Roy, Jenny, Maltais, René, Rouleau, Mélanie, Neveu, Bertrand, Pouliot, Frédéric, Poirier, Donald

“…In the fight against androgen-sensitive prostate cancer, the enzyme 17[beta]-hydroxysteroid dehydrogenase type 3 (17[beta]-HSD3) is an attractive therapeutic…”
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Reprint of “In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3” by Roy, Jenny, Fournier, Michelle-Audrey, Maltais, René, Kenmogne, Lucie Carolle, Poirier, Donald

“…•17β-HSD3 is involved in the formation of androgenic hormone testosterone (T).•RM-532-105 is an androsterone derivative inhibiting 17β-HSD3.•RM-532-105…”
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In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3 by Roy, Jenny, Fournier, Michelle-Audrey, Maltais, René, Kenmogne, Lucie Carolle, Poirier, Donald

“…•17β-HSD3 is involved in the formation of androgenic hormone testosterone (T).•RM-532-105 is an androsterone derivative inhibiting 17β-HSD3.•RM-532-105…”
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