Search Results - "Kenkel, Justin A"

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer by Bhattacharya, Nupur, Yuan, Robert, Prestwood, Tyler R., Penny, Hweixian Leong, DiMaio, Michael A., Reticker-Flynn, Nathan E., Krois, Charles R., Kenkel, Justin A., Pham, Tho D., Carmi, Yaron, Tolentino, Lorna, Choi, Okmi, Hulett, Reyna, Wang, Jinshan, Winer, Daniel A., Napoli, Joseph L., Engleman, Edgar G.

“…Although all-trans-retinoic acid (atRA) is a key regulator of intestinal immunity, its role in colorectal cancer (CRC) is unknown. We found that mice with…”
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An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer by Kenkel, Justin A, Tseng, William W, Davidson, Matthew G, Tolentino, Lorna L, Choi, Okmi, Bhattacharya, Nupur, Seeley, E Scott, Winer, Daniel A, Reticker-Flynn, Nathan E, Engleman, Edgar G

“…Pancreatic ductal adenocarcinoma (PDAC) after complete surgical resection is often followed by distant metastatic relapse for reasons that remain unclear. In…”
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Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma by Penny, Hweixian Leong, Sieow, Je Lin, Gun, Sin Yee, Lau, Mai Chan, Lee, Bernett, Tan, Jasmine, Phua, Cindy, Toh, Florida, Nga, Yvonne, Yeap, Wei Hseun, Janela, Baptiste, Kumar, Dilip, Chen, Hao, Yeong, Joe, Kenkel, Justin A, Pang, Angela, Lim, Diana, Toh, Han Chong, Hon, Tony Lim Kiat, Johnson, Christopher I, Khameneh, Hanif Javanmard, Mortellaro, Alessandra, Engleman, Edgar G, Rotzschke, Olaf, Ginhoux, Florent, Abastado, Jean-Pierre, Chen, Jinmiao, Wong, Siew Cheng

“…Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of…”
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Enteric Glia Play a Critical Role in Promoting the Development of Colorectal Cancer by Yuan, Robert, Bhattacharya, Nupur, Kenkel, Justin A, Shen, Jeanne, DiMaio, Michael A, Bagchi, Sreya, Prestwood, Tyler R, Habtezion, Aida, Engleman, Edgar G

“…Enteric glia are a distinct population of peripheral glial cells in the enteric nervous system that regulate intestinal homeostasis, epithelial barrier…”
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Th17 cells induce Th1-polarizing monocyte-derived dendritic cells by Davidson, Matthew G, Alonso, Michael N, Yuan, Robert, Axtell, Robert C, Kenkel, Justin A, Suhoski, Megan M, González, Joseph C, Steinman, Lawrence, Engleman, Edgar G

“…In chronically inflamed tissues, such as those affected by autoimmune disease, activated Th cells often colocalize with monocytes. We investigate in this study…”
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In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells by Davidson, Matthew G, Alonso, Michael N, Kenkel, Justin A, Suhoski, Megan M, González, Joseph C, Yuan, Robert, Engleman, Edgar G

“…Two critical functions of dendritic cells (DC) are to activate and functionally polarize T cells. Activated T cells can, in turn, influence DC maturation,…”
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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis by Reticker-Flynn, Nathan E., Zhang, Weiruo, Belk, Julia A., Basto, Pamela A., Escalante, Nichole K., Pilarowski, Genay O.W., Bejnood, Alborz, Martins, Maria M., Kenkel, Justin A., Linde, Ian L., Bagchi, Sreya, Yuan, Robert, Chang, Serena, Spitzer, Matthew H., Carmi, Yaron, Cheng, Jiahan, Tolentino, Lorna L., Choi, Okmi, Wu, Nancy, Kong, Christina S., Gentles, Andrew J., Sunwoo, John B., Satpathy, Ansuman T., Plevritis, Sylvia K., Engleman, Edgar G.

“…For many solid malignancies, lymph node (LN) involvement represents a harbinger of distant metastatic disease and, therefore, an important prognostic factor…”
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Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity by Carmi, Yaron, Spitzer, Matthew H., Linde, Ian L., Burt, Bryan M., Prestwood, Tyler R., Perlman, Nicola, Davidson, Matthew G., Kenkel, Justin A., Segal, Ehud, Pusapati, Ganesh V., Bhattacharya, Nupur, Engleman, Edgar G.

“…Naturally occurring tumour-binding IgG antibodies are shown to initiate the rejection of allogeneic tumours, whereby Fc-receptor-mediated uptake of tumour…”
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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies by Winer, Daniel A, Winer, Shawn, Shen, Lei, Wadia, Persis P, Yantha, Jason, Paltser, Geoffrey, Tsui, Hubert, Wu, Ping, Davidson, Matthew G, Alonso, Michael N, Leong, Hwei X, Glassford, Alec, Caimol, Maria, Kenkel, Justin A, Tedder, Thomas F, McLaughlin, Tracey, Miklos, David B, Dosch, H-Michael, Engleman, Edgar G

“…Edgar Engleman and his colleagues show that B cell production of pathogenic IgG antibodies is involved in obesity-induced insulin resistance. They also show…”
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A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence by Mamedov, Murad R., Scholzen, Anja, Nair, Ramesh V., Cumnock, Katherine, Kenkel, Justin A., Oliveira, Jose Henrique M., Trujillo, Damian L., Saligrama, Naresha, Zhang, Yue, Rubelt, Florian, Schneider, David S., Chien, Yueh-hsiu, Sauerwein, Robert W., Davis, Mark M.

“…Despite evidence that γδ T cells play an important role during malaria, their precise role remains unclear. During murine malaria induced by Plasmodium…”
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N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2 by Zhou, Matthew N., Delaveris, Corleone S., Kramer, Jessica R., Kenkel, Justin A., Engleman, Edgar G., Bertozzi, Carolyn R.

“…The C‐type lectins dectin‐1 and dectin‐2 contribute to innate immunity against microbial pathogens by recognizing their foreign glycan structures. These…”
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Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity by Ackerman, Shelley E, Pearson, Cecelia I, Gregorio, Joshua D, Gonzalez, Joseph C, Kenkel, Justin A, Hartmann, Felix J, Luo, Angela, Ho, Po Y, LeBlanc, Heidi, Blum, Lisa K, Kimmey, Samuel C, Luo, Andrew, Nguyen, Murray L, Paik, Jason C, Sheu, Lauren Y, Ackerman, Benjamin, Lee, Arthur, Li, Hai, Melrose, Jennifer, Laura, Richard P, Ramani, Vishnu C, Henning, Karla A, Jackson, David Y, Safina, Brian S, Yonehiro, Grant, Devens, Bruce H, Carmi, Yaron, Chapin, Steven J, Bendall, Sean C, Kowanetz, Marcin, Dornan, David, Engleman, Edgar G, Alonso, Michael N

“…Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity…”
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Development of an Orthotopic Model of Invasive Pancreatic Cancer in an Immunocompetent Murine Host by TSENG, William W, WINER, Daniel, KENKEL, Justin A, CHOI, Okmi, SHAIN, Alan H, POLLACK, Jonathan R, FRENCH, Randy, LOWY, Andrew M, ENGLEMAN, Edgar G

“…The most common preclinical models of pancreatic adenocarcinoma utilize human cells or tissues that are xenografted into immunodeficient hosts. Several…”
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N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2 by Zhou, Matthew N., Delaveris, Corleone S., Kramer, Jessica R., Kenkel, Justin A., Engleman, Edgar G., Bertozzi, Carolyn R.

“…The C‐type lectins dectin‐1 and dectin‐2 contribute to innate immunity against microbial pathogens by recognizing their foreign glycan structures. These…”
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Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice by Penny, Hweixian Leong, Prestwood, Tyler R, Bhattacharya, Nupur, Sun, Fionna, Kenkel, Justin A, Davidson, Matthew G, Shen, Lei, Zuniga, Luis A, Seeley, E Scott, Pai, Reetesh, Choi, Okmi, Tolentino, Lorna, Wang, Jinshan, Napoli, Joseph L, Engleman, Edgar G

“…Chronic intestinal inflammation accompanies familial adenomatous polyposis (FAP) and is a major risk factor for colorectal cancer in patients with this…”
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N-carboxyanhydride polymerization of glycopolypeptides that activate antigen presenting cells through Dectin-1 and -2 by Zhou, Matthew N., Delaveris, Corleone S., Kramer, Jessica R., Kenkel, Justin A., Engleman, Edgar G., Bertozzi, Carolyn R.

“…The C-type lectins Dectin-1 and Dectin-2 contribute to innate immunity against microbial pathogens by recognizing their foreign glycan structures. These…”
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Abstract PR04: Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immunosuppression by Reticker-Flynn, Nathan E., Basto, Pamela A., Zhang, Weiruo, Bejnood, Alborz, Kenkel, Justin A., Martins, Maria M., Chang, Serena, Gentles, Andrew J., Sunwoo, John B., Plevritis, Sylvia K., Engleman, Edgar G.

“…Abstract The majority of cancer-associated deaths result from distant organ metastasis rather than the primary tumor, yet the mechanisms that enable this…”
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Novel M-CSF-producing γδ T cells protect against recurrent malaria by Mamedov, Murad R., Scholzen, Anja, Nair, Ramesh V., Cumnock, Katherine, Kenkel, Justin A., Oliveira, Jose H. M., Trujillo, Damian L., Saligrama, Naresha, Zhang, Yue, Rubelt, Florian, Schneider, David S., Chien, Yueh-hsiu, Sauerwein, Robert, Davis, Mark M.

“…Abstract In 2016, there were 216 million malaria cases – 445,000 of which resulted in deaths. Despite overwhelming evidence that γδ T cells strongly respond…”
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Abstract 1559: TLR7/8 immune-stimulating antibody conjugates elicit robust myeloid activation leading to enhanced effector function and anti-tumor immunity in pre-clinical models by Ackerman, Shelley E., Gonzalez, Joseph C., Gregorio, Josh D., Paik, Jason C., Hartmann, Felix J., Kenkel, Justin A., Lee, Arthur, Luo, Angela, Pearson, Cecelia I., Nguyen, Murray L., Ackerman, Benjamin, Sheu, Lauren Y., Laura, Richard P., Chapin, Steven J., Safina, Brian S., Bendall, Sean C., Dornan, David, Engleman, Edgar G., Alonso, Michael N.

“…Abstract Deficient anti-tumor immunity often results from an immunosuppressive tumor microenvironment (TME) that renders antigen presenting cells (APCs) unable…”
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Abstract 5337: Profiling of human CD34+ donors in a myeloid-supportive HIS model provides increased predictability and facilitates study design for evaluation of immuno-oncology therapeutics by Richardson, Janell R., MacBride, Megan M., Andino, Esther, Sack, Emily, Smith, Nicholas, Ho, Po Y., Xiao, Fang, McEachin, Katelynn A., Omstead, David T., Grgich, Rachel, Alonso, Michael N., Kenkel, Justin A., Ackerman, Shelley E.

“…Abstract Background: Humanized immune system (HIS) mice are critical immuno-oncology tools for in vivo evaluation of therapeutic target engagement and…”
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