Search Results - "Kenji Tamura"

Differences of cyclin-dependent kinase 4/6 inhibitor, palbociclib and abemaciclib, in breast cancer by Tamura, Kenji

“…Both palbociclib and abemaciclib are, oral, highly selective inhibitors of cyclin-dependent kinase 4 and 6, which are proteins involved in cell differentiation…”
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Baseline Profile of Participants in the Japan Environment and Children’s Study (JECS) by Michikawa, Takehiro, Nitta, Hiroshi, Nakayama, Shoji F., Yamazaki, Shin, Isobe, Tomohiko, Tamura, Kenji, Suda, Eiko, Ono, Masaji, Yonemoto, Junzo, Iwai-Shimada, Miyuki, Kobayashi, Yayoi, Suzuki, Go, Kawamoto, Toshihiro

“…Background: The Japan Environment and Children’s Study (JECS), known as Ecochil-Chosa in Japan, is a nationwide birth cohort study investigating the…”
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Development of cell-cycle checkpoint therapy for solid tumors by Tamura, Kenji

“…Cellular proliferation is tightly controlled by several cell-cycle checkpoint proteins. In cancer, the genes encoding these proteins are often disrupted and…”
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Feasibility and utility of a panel testing for 114 cancer‐associated genes in a clinical setting: A hospital‐based study by Sunami, Kuniko, Ichikawa, Hitoshi, Kubo, Takashi, Kato, Mamoru, Fujiwara, Yutaka, Shimomura, Akihiko, Koyama, Takafumi, Kakishima, Hiroki, Kitami, Mayuko, Matsushita, Hiromichi, Furukawa, Eisaku, Narushima, Daichi, Nagai, Momoko, Taniguchi, Hirokazu, Motoi, Noriko, Sekine, Shigeki, Maeshima, Akiko, Mori, Taisuke, Watanabe, Reiko, Yoshida, Masayuki, Yoshida, Akihiko, Yoshida, Hiroshi, Satomi, Kaishi, Sukeda, Aoi, Hashimoto, Taiki, Shimizu, Toshio, Iwasa, Satoru, Yonemori, Kan, Kato, Ken, Morizane, Chigusa, Ogawa, Chitose, Tanabe, Noriko, Sugano, Kokichi, Hiraoka, Nobuyoshi, Tamura, Kenji, Yoshida, Teruhiko, Fujiwara, Yasuhiro, Ochiai, Atsushi, Yamamoto, Noboru, Kohno, Takashi

“…Next‐generation sequencing (NGS) of tumor tissue (ie, clinical sequencing) can guide clinical management by providing information about actionable gene…”
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Novel combination of serum microRNA for detecting breast cancer in the early stage by Shimomura, Akihiko, Shiino, Sho, Kawauchi, Junpei, Takizawa, Satoko, Sakamoto, Hiromi, Matsuzaki, Juntaro, Ono, Makiko, Takeshita, Fumitaka, Niida, Shumpei, Shimizu, Chikako, Fujiwara, Yasuhiro, Kinoshita, Takayuki, Tamura, Kenji, Ochiya, Takahiro

“…MicroRNA (miRNA), which are stably present in serum, have been reported to be potentially useful for detecting cancer. In the present study, we examined the…”
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Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer by Modi, Shanu, Saura, Cristina, Yamashita, Toshinari, Park, Yeon Hee, Kim, Sung-Bae, Tamura, Kenji, Andre, Fabrice, Iwata, Hiroji, Ito, Yoshinori, Tsurutani, Junji, Sohn, Joohyuk, Denduluri, Neelima, Perrin, Christophe, Aogi, Kenjiro, Tokunaga, Eriko, Im, Seock-Ah, Lee, Keun Seok, Hurvitz, Sara A, Cortes, Javier, Lee, Caleb, Chen, Shuquan, Zhang, Lin, Shahidi, Javad, Yver, Antoine, Krop, Ian

“…In this single-group, phase 2 study, the use of trastuzumab deruxtecan resulted in a response in 60% of women with HER2-positive advanced breast cancer who had…”
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Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier by Tominaga, Naoomi, Kosaka, Nobuyoshi, Ono, Makiko, Katsuda, Takeshi, Yoshioka, Yusuke, Tamura, Kenji, Lötvall, Jan, Nakagama, Hitoshi, Ochiya, Takahiro

“…Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through…”
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Six-year monitoring of the vertical distribution of radiocesium in three forest soils after the Fukushima Dai-ichi Nuclear Power Plant accident by Takahashi, Junko, Onda, Yuichi, Hihara, Daichi, Tamura, Kenji

“…After the Fukushima Dai-ichi Nuclear Power Plant accident on March 2011, several studies showed that the downward migration of 137Cs from litter to mineral…”
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High-throughput functional evaluation of BRCA2 variants of unknown significance by Ikegami, Masachika, Kohsaka, Shinji, Ueno, Toshihide, Momozawa, Yukihide, Inoue, Satoshi, Tamura, Kenji, Shimomura, Akihiko, Hosoya, Noriko, Kobayashi, Hiroshi, Tanaka, Sakae, Mano, Hiroyuki

“…Numerous nontruncating missense variants of the BRCA2 gene have been identified, but there is a lack of convincing evidence, such as familial data,…”
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Tethering Organic Disulfides to Layered Silicates: A Versatile Strategy for Photo-Controllable Dynamic Chemistry and Functionalization by Tanks, Jonathon, Hiroi, Takashi, Tamura, Kenji, Naito, Kimiyoshi

“…The dynamic covalent chemistry of molecular disulfides has been studied extensively in solution, but their reactivity when confined to nanospaces has not been…”
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Caffeine Adsorption on Natural and Synthetic Smectite Clays: Adsorption Mechanism and Effect of Interlayer Cation Valence by Sakuma, Hiroshi, Tamura, Kenji, Hashi, Kenjiro, Kamon, Masumi

“…There is currently significant interest in adsorbents for selective removal of caffeine from water. Here, we examined caffeine adsorption in a natural…”
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Efficacy and safety of nivolumab in Japanese patients with uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma: Multicenter, open‐label phase 2 trial by Tamura, Kenji, Hasegawa, Kosei, Katsumata, Noriyuki, Matsumoto, Koji, Mukai, Hirofumi, Takahashi, Shunji, Nomura, Hiroyuki, Minami, Hironobu

“…Nivolumab is a human monoclonal antibody against the immune checkpoint receptor programmed death‐1, inhibiting binding to programmed death‐ligand 1 or 2 (PD‐L1…”
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Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced, PD-L1-positive papillary or follicular thyroid cancer by Mehnert, Janice M, Varga, Andrea, Brose, Marcia S, Aggarwal, Rahul R, Lin, Chia-Chi, Prawira, Amy, de Braud, Filippo, Tamura, Kenji, Doi, Toshihiko, Piha-Paul, Sarina A, Gilbert, Jill, Saraf, Sanatan, Thanigaimani, Pradeep, Cheng, Jonathan D, Keam, Bhumsuk

“…Treatment options for advanced thyroid cancer refractory to standard therapies are limited. The safety and efficacy of pembrolizumab were evaluated in patients…”
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Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts by Takahashi, Masamichi, Miki, Shunichiro, Fujimoto, Kenji, Fukuoka, Kohei, Matsushita, Yuko, Maida, Yoshiko, Yasukawa, Mami, Hayashi, Mitsuhiro, Shinkyo, Raku, Kikuchi, Kiyomi, Mukasa, Akitake, Nishikawa, Ryo, Tamura, Kenji, Narita, Yoshitaka, Hamada, Akinobu, Masutomi, Kenkichi, Ichimura, Koichi

“…Glioblastoma is one of the most devastating human malignancies for which a novel efficient treatment is urgently required. This pre–clinical study shows that…”
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The effects of geographic region and cultivar on oxidative stability and elemental analysis of Tunisian extra virgin olive oil by Wali, Ahmed, Damak, Fadwa, Kawada, Kiyokazu, Isoda, Hiroko, Tamura, Kenji, Ksibi, Mohamed

“…Metals contents were determined in 18 samples of Extra Virgin Olive Oil (EVOO) collected from different regions in Tunisia, after microwave digestion with…”
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Glycol lignin/MAH-g-PP blends and composites with exceptional mechanical properties for automotive applications by Tanks, Jonathon, Tamura, Kenji, Naito, Kimiyoshi, Nge, Thi Thi, Yamada, Tatsuhiko

“…Lightweight plastics and their composites are being increasingly used in automobiles to reduce emissions and costs, but the market demand for fossil fuel-based…”
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Uptake of Cesium and Strontium Ions by Artificially Altered Phlogopite by Tamura, Kenji, Kogure, Toshihiro, Watanabe, Yujiro, Nagai, Chiemi, Yamada, Hirohisa

“…Potassium (K+) phlogopite was transformed to a vermiculite-like mineral through a topotactic reaction under acidic conditions (pH 2) followed by hydrothermal…”
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Romidepsin and tamoxifen cooperatively induce senescence of pancreatic cancer cells through downregulation of FOXM1 expression and induction of reactive oxygen species/lipid peroxidation by Okuni, Noriko, Honma, Yoshio, Urano, Takeshi, Tamura, Kenji

“…Background Although improvement has been made in therapeutic strategies against pancreatic carcinoma, overall survival has not significantly enhanced over the…”
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Pembrolizumab for the treatment of programmed death–ligand 1‒positive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTE‐028 study by Mehnert, Janice M., Bergsland, Emily, O’Neil, Bert H., Santoro, Armando, Schellens, Jan H. M., Cohen, Roger B., Doi, Toshihiko, Ott, Patrick A., Pishvaian, Michael J., Puzanov, Igor, Aung, Kyaw L., Hsu, Chiun, Le Tourneau, Christophe, Hollebecque, Antoine, Élez, Elena, Tamura, Kenji, Gould, Marlena, Yang, Ping, Stein, Karen, Piha‐Paul, Sarina A.

“…Background Despite a protracted disease course and multiple available therapies, patients with well‐differentiated neuroendocrine tumors (NETs) inevitably…”
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Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1 by Takahashi, Ryou-u, Miyazaki, Hiroaki, Takeshita, Fumitaka, Yamamoto, Yusuke, Minoura, Kaho, Ono, Makiko, Kodaira, Makoto, Tamura, Kenji, Mori, Masaki, Ochiya, Takahiro

“…Cancer stem cells (CSCs) have been identified in various types of cancer; however, the mechanisms by which cells acquire CSC properties such as drug resistance…”
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