Search Results - "Kendall, Jackie D"

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types by Jamieson, Stephen, Flanagan, Jack U, Kolekar, Sharada, Buchanan, Christina, Kendall, Jackie D, Lee, Woo-Jeong, Rewcastle, Gordon W, Denny, William A, Singh, Ripudaman, Dickson, James, Baguley, Bruce C, Shepherd, Peter R

“…Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted…”
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Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo by Smith, Greg C, Ong, Wee Kiat, Rewcastle, Gordon W, Kendall, Jackie D, Han, Weiping, Shepherd, Peter R

“…In in vitro studies class-I PI3Ks (phosphoinositide 3-kinases), class-II PI3Ks and mTOR (mammalian target of rapamycin) have all been described as having roles…”
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Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling by Chaussade, Claire, Rewcastle, Gordon W, Kendall, Jackie D, Denny, William A, Cho, Kitty, Grønning, Line M, Chong, Mei Ling, Anagnostou, Sasha H, Jackson, Shaun P, Daniele, Nathalie, Shepherd, Peter R

“…Recent genetic knock-in and pharmacological approaches have suggested that, of class IA PI3Ks (phosphatidylinositol 3-kinases), it is the p110alpha isoform…”
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Potential global fire monitoring from EOS-MODIS by Kaufman, Yoram J., Justice, Christopher O., Flynn, Luke P., Kendall, Jackie D., Prins, Elaine M., Giglio, Louis, Ward, Darold E., Menzel, W. Paul, Setzer, Alberto W.

“…The National Aeronautic and Space Administration (NASA) plans to launch the moderate resolution imaging spectroradiometer (MODIS) on the polarorbiting Earth…”
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Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity by Buchanan, Christina M, Dickson, James M J, Lee, Woo-Jeong, Guthridge, Mark A, Kendall, Jackie D, Shepherd, Peter R

“…In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targeting regulatory autophosphorylation sites and exogenous…”
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Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) by Rewcastle, Gordon W, Gamage, Swarna A, Flanagan, Jack U, Frederick, Raphael, Denny, William A, Baguley, Bruce C, Kestell, Philip, Singh, Ripudaman, Kendall, Jackie D, Marshall, Elaine S, Lill, Claire L, Lee, Woo-Jeong, Kolekar, Sharada, Buchanan, Christina M, Jamieson, Stephen M. F, Shepherd, Peter R

“…A structure–activity relationship (SAR) study of the pan class I PI 3-kinase inhibitor…”
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Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474 by Giddens, Anna C., Gamage, Swarna A., Kendall, Jackie D., Lee, Woo-Jeong, Baguley, Bruce C., Buchanan, Christina M., Jamieson, Stephen M.F., Dickson, James M.J., Shepherd, Peter R., Denny, William A., Rewcastle, Gordon W.

“…[Display omitted] Replacing one of the morpholine groups of the phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 with a variety of sulfonamide-linked…”
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Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474 by Gamage, Swarna A., Giddens, Anna C., Tsang, Kit Y., Flanagan, Jack U., Kendall, Jackie D., Lee, Woo-Jeong, Baguley, Bruce C., Buchanan, Christina M., Jamieson, Stephen M.F., Shepherd, Peter R., Denny, William A., Rewcastle, Gordon W.

“…[Display omitted] Replacement of one of the morpholine groups of the phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 (1) with sulfonamide containing…”
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Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon–carbon bond formation at the 2-position of the amine by Tomek, Petr, Palmer, Brian D., Kendall, Jackie D., Flanagan, Jack U., Ching, Lai-Ming

“…Tryptophan catabolism along the kynurenine pathway is associated with a number of pathologies including cataract formation and cancer. Whilst the chemical…”
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Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity by Gong, Grace Q, Kendall, Jackie D, Dickson, James M J, Rewcastle, Gordon W, Buchanan, Christina M, Denny, William A, Shepherd, Peter R, Flanagan, Jack U

“…Phosphoinositide 3-kinases (PI3Ks) are major regulators of many cellular functions, and hyperactivation of PI3K cell signalling pathways is a major target for…”
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Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors by Kendall, Jackie D., Giddens, Anna C., Tsang, Kit Yee, Marshall, Elaine S., Lill, Claire L., Lee, Woo-Jeong, Kolekar, Sharada, Chao, Mindy, Malik, Alisha, Yu, Shuqiao, Chaussade, Claire, Buchanan, Christina, Jamieson, Stephen M.F., Rewcastle, Gordon W., Baguley, Bruce C., Denny, William A., Shepherd, Peter R.

“…[Display omitted] As part of our investigation into pyrazolo[1,5-a]pyridines as novel p110α selective PI3 kinase inhibitors, we report a range of analogues…”
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Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors by Rewcastle, Gordon W, Kolekar, Sharada, Buchanan, Christina M, Gamage, Swarna A, Giddens, Anna C, Tsang, Kit Y, Kendall, Jackie D, Singh, Ripudaman, Lee, Woo-Jeong, Smith, Greg C, Han, Weiping, Matthews, David J, Denny, William A, Shepherd, Peter R, Jamieson, Stephen M F

“…Multiple therapeutic agents have been developed to target the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is frequently dysregulated in…”
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Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR by Kendall, Jackie D., Giddens, Anna C., Tsang, Kit Yee, Frédérick, Raphaël, Marshall, Elaine S., Singh, Ripudaman, Lill, Claire L., Lee, Woo-Jeong, Kolekar, Sharada, Chao, Mindy, Malik, Alisha, Yu, Shuqiao, Chaussade, Claire, Buchanan, Christina, Rewcastle, Gordon W., Baguley, Bruce C., Flanagan, Jack U., Jamieson, Stephen M.F., Denny, William A., Shepherd, Peter R.

“…Structure–activity relationship studies of the pyrazolo[1,5-a]pyridine class of PI3 kinase inhibitors show that substitution off the hydrazone nitrogen and…”
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Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors by Kendall, Jackie D., O’Connor, Patrick D., Marshall, Andrew J., Frédérick, Raphaël, Marshall, Elaine S., Lill, Claire L., Lee, Woo-Jeong, Kolekar, Sharada, Chao, Mindy, Malik, Alisha, Yu, Shuqiao, Chaussade, Claire, Buchanan, Christina, Rewcastle, Gordon W., Baguley, Bruce C., Flanagan, Jack U., Jamieson, Stephen M.F., Denny, William A., Shepherd, Peter R.

“…We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class…”
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Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) by Rewcastle, Gordon W., Gamage, Swarna A., Flanagan, Jack U., Kendall, Jackie D., Denny, William A., Baguley, Bruce C., Buchanan, Christina M., Chao, Mindy, Kestell, Philip, Kolekar, Sharada, Lee, Woo-Jeong, Lill, Claire L., Malik, Alisha, Singh, Ripudaman, Jamieson, Stephen M.F., Shepherd, Peter R.

“…A range of 4-substituted derivatives of the pan class I PI 3-kinase inhibitor 2-(difluoromethyl)-1-[4,6-di-(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole…”
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Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors by Kendall, Jackie D., Rewcastle, Gordon W., Frederick, Raphael, Mawson, Claire, Denny, William A., Marshall, Elaine S., Baguley, Bruce C., Chaussade, Claire, Jackson, Shaun P., Shepherd, Peter R.

“…A novel series of sulfonohydrazides were synthesised and evaluated for inhibition of isoforms of PI3K, and inhibition of cell proliferation. Molecular…”
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Phosphoinositide-3-kinase (PI3K) inhibitors: Identification of new scaffolds using virtual screening by Frédérick, Raphaël, Mawson, Claire, Kendall, Jackie D., Chaussade, Claire, Rewcastle, Gordon W., Shepherd, Peter R., Denny, William A.

“…In the present work, we used virtual screening (VS) of the ZINC database of 2.5 million compounds to seek new PI3K inhibitory scaffolds. The VS flowchart…”
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Synthesis and 1H, 13C and 15N NMR characterisation of substituted Pyrazolo[4,3-c]quinolines and related compounds by Black, Shannon L., O'Connor, Patrick D., Boyd, Maruta, Blaser, Adrian, Kendall, Jackie D.

“…A wide range of novel and known alkyl substituted pyrazolo[4,3-c]quinolines and related compounds were synthesized. Some of these compounds can undergo…”
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Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474) by Rewcastle, Gordon W., Gamage, Swarna A., Flanagan, Jack U., Frederick, Raphael, Denny, William A., Baguley, Bruce C., Kestell, Philip, Singh, Ripudaman, Kendall, Jackie D., Marshall, Elaine S., Lill, Claire L., Lee, Woo-Jeong, Kolekar, Sharada, Buchanan, Christina M., Jamieson, Stephen M. F., Shepherd, Peter R.

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Oncogenic Mutations of p110[alpha] Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity by Buchanan, Christina M, Dickson, James M. J, Lee, Woo-Jeong, Guthridge, Mark A, Kendall, Jackie D, Shepherd, Peter R

“…In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targeting regulatory autophosphorylation sites and exogenous…”
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