Search Results - "Kendall, Debra A."

Signal peptidase I: Cleaving the way to mature proteins by Auclair, Sarah M., Bhanu, Meera K., Kendall, Debra A.

“…Signal peptidase I (SPase I) is critical for the release of translocated preproteins from the membrane as they are transported from a cytoplasmic site of…”
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Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1 by Flores-Otero, Jacqueline, Ahn, Kwang H., Delgado-Peraza, Francheska, Mackie, Ken, Kendall, Debra A., Yudowski, Guillermo A.

“…G protein-coupled receptors (GPCRs) are the major transducers of external stimuli and key therapeutic targets in many pathological conditions. When activated…”
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Anti-inflammatory and antinociceptive effects of the selective cannabinoid CB2 receptor agonist ABK5 by Tang, Yaliang, Wolk, Barbara, Britch, Stevie C., Craft, Rebecca M., Kendall, Debra A.

“…Cannabinoid receptors are a potential target for anti-inflammatory and pain therapeutics. There are two subtypes, CB1 and CB2, and Δ9-tetrahydrocannabinol…”
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Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1) by Khurana, Leepakshi, Ali, Hamed I, Olszewska, Teresa, Ahn, Kwang H, Damaraju, Aparna, Kendall, Debra A, Lu, Dai

“…5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)­phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1…”
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Characterization of Subtype Selective Cannabinoid CB2 Receptor Agonists as Potential Anti-Inflammatory Agents by Tang, Yaliang, Wolk, Barbara, Nolan, Ryan, Scott, Caitlin E., Kendall, Debra A.

“…Activation of the CB2 receptor has been shown to have anti-inflammatory and antinociceptive effects without causing psychoactive effects. Previously, we…”
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Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1 by Dopart, Rachel, Immadi, Sri Sujana, Lu, Dai, Kendall, Debra A.

“…•PSNCBAM-1 is an allosteric modulator of the cannabinoid receptor 1.•Derivatives of PSNCBAM-1 were made, to reduce the total rings in the structure.•Several…”
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Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization by Ahn, Kwang H, Bertalovitz, Alexander C, Mierke, Dale F, Kendall, Debra A

“…The seven transmembrane alpha-helices of G protein-coupled receptors (GPCRs) are the hallmark of this superfamily. Intrahelical interactions are critical to…”
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Mapping of the SecA Signal Peptide Binding Site and Dimeric Interface by Using the Substituted Cysteine Accessibility Method by Bhanu, Meera K, Zhao, Ping, Kendall, Debra A

“…SecA is an ATPase nanomotor critical for bacterial secretory protein translocation. Secretory proteins carry an amino-terminal signal peptide that is…”
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Defining the Escherichia coli SecA Dimer Interface Residues through In Vivo Site-Specific Photo-Cross-Linking by Yu, Dongmei, Wowor, Andy J, Cole, James L, Kendall, Debra A

“…The motor protein SecA is a core component of the bacterial general secretory (Sec) pathway and is essential for cell viability. Despite evidence showing that…”
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Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease by Kendall, Debra A, Yudowski, Guillermo A

“…The identification and cloning of the two major cannabinoid (CB and CB ) receptors together with the discovery of their endogenous ligands in the late 80s and…”
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Hydrophobic Residues in Helix 8 of Cannabinoid Receptor 1 Are Critical for Structural and Functional Properties by Ahn, Kwang H, Nishiyama, Akiko, Mierke, Dale F, Kendall, Debra A

“…In addition to the heptahelical transmembrane domain shared by all G protein-coupled receptors (GPCRs), many class A GPCRs adopt a helical domain, termed helix…”
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Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities by Khurana, Leepakshi, Mackie, Ken, Piomelli, Daniele, Kendall, Debra A.

“…Cannabinoid pharmacology has been intensely studied because of cannabis’ pervasive medicinal and non-medicinal uses as well as for the therapeutic potential of…”
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Oligomeric states of the SecA and SecYEG core components of the bacterial Sec translocon by Rusch, Sharyn L., Kendall, Debra A.

“…Many proteins synthesized in the cytoplasm ultimately function in non-cytoplasmic locations. In Escherichia coli, the general secretory (Sec) pathway…”
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Membrane assembly of the cannabinoid receptor 1: impact of a long N-terminal tail by Andersson, Helena, D'Antona, Aaron M, Kendall, Debra A, Von Heijne, Gunnar, Chin, Chen-Ni

“…The human cannabinoid receptor 1 (CB1) belongs to the G protein-coupled receptor (GPCR) family. Among the members of GPCR family, it has an exceptionally long…”
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Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and Gi Protein-independent ERK1/2 Kinase Activation by Ahn, Kwang H., Mahmoud, Mariam M., Kendall, Debra A.

“…The cannabinoid receptor 1 (CB1), a member of the class A G protein-coupled receptor family, is expressed in brain tissue where agonist stimulation primarily…”
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Minireview: From the Bench, Toward the Clinic: Therapeutic Opportunities for Cannabinoid Receptor Modulation by Picone, Robert P, Kendall, Debra A

“…The effects of cannabinoids have been known for centuries and over the past several decades two G protein-coupled receptors, CB1 and CB2, that are responsible…”
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Allosteric modulators restore orthosteric agonist binding to mutated CB1 receptors by Dopart, Rachel, Kendall, Debra A

“…Abstract Objectives To determine if diminished orthosteric agonist binding due to mutations in extracellular loops 1 or 2 of the cannabinoid receptor 1 (CB1)…”
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Translational potential of allosteric modulators targeting the cannabinoid CB1 receptor by Lu, Dai, Immadi, Sri Sujana, Wu, Zhixing, Kendall, Debra A.

“…The cannabinoid type-1 (CB 1 ) receptor, a G-protein-coupled receptor, is an attractive target for drug discovery due to its involvement in many physiological…”
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Translational potential of allosteric modulators targeting the cannabinoid CB 1 receptor by Lu, Dai, Immadi, Sri Sujana, Wu, Zhixing, Kendall, Debra A

“…The cannabinoid type-1 (CB ) receptor, a G-protein-coupled receptor, is an attractive target for drug discovery due to its involvement in many physiological…”
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Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity by Dopart, Rachel, Lu, Dai, Lichtman, Aron H., Kendall, Debra A.

“…The cannabinoid receptor 1 (CB 1 ) is a G protein-coupled receptor (GPCR) that is located primarily in the central nervous system. CB 1 is a therapeutic target…”
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