Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns

To compare patterns of gene expression following preconditioning cyclic light rearing versus preconditioning aerobic exercise. BALB/C mice were preconditioned either by rearing in 800 lx 12:12 h cyclic light for 8 days or by running on treadmills for 9 days, exposed to toxic levels of light to cause...

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Bibliographic Details
Published in:	Advances in experimental medicine and biology Vol. 854; p. 443
Main Authors:	Chrenek, Micah A, Sellers, Jana T, Lawson, Eric C, Cunha, Priscila P, Johnson, Jessica L, Girardot, Preston E, Kendall, Cristina, Han, Moon K, Hanif, Adam, Ciavatta, Vincent T, Gogniat, Marissa A, Nickerson, John M, Pardue, Machelle T, Boatright, Jeffrey H
Format:	Journal Article
Language:	English
Published:	United States 01-01-2016
Subjects:	Animals Electroretinography Leukemia Inhibitory Factor - genetics Light - adverse effects Male Mice, Inbred BALB C Photoperiod Physical Conditioning, Animal - physiology Retina - metabolism Retina - pathology Retina - radiation effects Retinal Degeneration - etiology Retinal Degeneration - genetics Retinal Degeneration - physiopathology Reverse Transcriptase Polymerase Chain Reaction Transcriptome - genetics Transcriptome - radiation effects Retinal degeneration Light-induced retinal degeneration Cyclic light rearing Preconditioning Aerobic exercise
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Summary:	To compare patterns of gene expression following preconditioning cyclic light rearing versus preconditioning aerobic exercise. BALB/C mice were preconditioned either by rearing in 800 lx 12:12 h cyclic light for 8 days or by running on treadmills for 9 days, exposed to toxic levels of light to cause light-induced retinal degeneration (LIRD), then sacrificed and retinal tissue harvested. Subsets of mice were maintained for an additional 2 weeks and for assessment of retinal function by electroretinogram (ERG). Both preconditioning protocols partially but significantly preserved retinal function and morphology and induced similar leukemia inhibitory factor (LIF) gene expression pattern. The data demonstrate that exercise preconditioning and cyclic light preconditioning protect photoreceptors against LIRD and evoke a similar pattern of retinal LIF gene expression. It may be that similar stress response pathways mediate the protection provided by the two preconditioning modalities.
ISSN:	0065-2598
DOI:	10.1007/978-3-319-17121-0_59