Search Results - "Kendall, Alexandra C"

Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis by Borsini, Alessandra, Nicolaou, Anna, Camacho-Muñoz, Dolores, Kendall, Alexandra C., Di Benedetto, Maria Grazia, Giacobbe, Juliette, Su, Kuan-Pin, Pariante, Carmine M.

“…Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can exert antidepressant, anti-inflammatory and neuroprotective properties, but the exact molecular…”
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Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids by Astarita, Giuseppe, Kendall, Alexandra C., Dennis, Edward A., Nicolaou, Anna

“…Oxidation of polyunsaturated fatty acids (PUFA) through enzymatic or non-enzymatic free radical-mediated reactions can yield an array of lipid metabolites…”
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Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation by Trompette, Aurélien, Pernot, Julie, Perdijk, Olaf, Alqahtani, Rayed Ali A., Domingo, Jaime Santo, Camacho-Muñoz, Dolores, Wong, Nicholas C., Kendall, Alexandra C., Wiederkehr, Andreas, Nicod, Laurent P., Nicolaou, Anna, von Garnier, Christophe, Ubags, Niki D.J., Marsland, Benjamin J.

“…Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen…”
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Distribution of Bioactive Lipid Mediators in Human Skin by Kendall, Alexandra C., Pilkington, Suzanne M., Massey, Karen A., Sassano, Gary, Rhodes, Lesley E., Nicolaou, Anna

“…The skin produces bioactive lipids that participate in physiological and pathological states, including homeostasis, induction, propagation, and resolution of…”
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Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E2 by Newson, Justine, Motwani, Madhur P., Kendall, Alexandra C., Nicolaou, Anna, Muccioli, Giulio G., Alhouayek, Mireille, Bennett, Melanie, Van De Merwe, Rachel, James, Sarah, De Maeyer, Roel P.H., Gilroy, Derek W.

“…Acute inflammation is characterized by granulocyte infiltration followed by efferocytosing mononuclear phagocytes, which pave the way for inflammatory…”
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Plasma S1P and Sphingosine are not Different Prior to Pre-Eclampsia in Women at High Risk of Developing the Disease by Johnstone, Edward D., Westwood, Melissa, Dilworth, Mark, Wray, Jonathan R., Kendall, Alexandra C., Nicolaou, Anna, Myers, Jenny E.

“…Sphingolipids like sphingosine-1-phosphate (S1P) have been implicated in the pathophysiology of pre-eclampsia. We hypothesized that plasma S1P would be…”
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Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy by Kendall, Alexandra C., Pilkington, Suzanne M., Wray, Jonathan R., Newton, Victoria L., Griffiths, Christopher E. M., Bell, Mike, Watson, Rachel E. B., Nicolaou, Anna

“…The menopause can lead to epidermal changes that are alleviated by hormone replacement therapy (HRT). We hypothesise that these changes could relate to altered…”
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Rheumatoid arthritis reprograms circadian output pathways by Poolman, Toryn M, Gibbs, Julie, Walker, Amy L, Dickson, Suzanna, Farrell, Laura, Hensman, James, Kendall, Alexandra C, Maidstone, Robert, Warwood, Stacey, Loudon, Andrew, Rattray, Magnus, Bruce, Ian N, Nicolaou, Anna, Ray, David W

“…We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA). We recruited adults (age 16-80 years old) with a…”
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Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia by Feehan, Karen T., Bridgewater, Hannah E., Stenkiewicz-Witeska, Jan, De Maeyer, Roel P. H., Ferguson, John, Mack, Matthias, Brown, Jeremy, Ercoli, Giuseppe, Mawer, Connar M., Akbar, Arne N., Glanville, James R. W., Jalali, Parinaaz, Bracken, Olivia V., Nicolaou, Anna, Kendall, Alexandra C., Sugimoto, Michelle A., Gilroy, Derek W.

“…Resolving inflammation is thought to return the affected tissue back to homoeostasis but recent evidence supports a non-linear model of resolution involving a…”
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Lipidomics for translational skin research: A primer for the uninitiated by Kendall, Alexandra C., Koszyczarek, Marta M., Jones, Emrys A., Hart, Philippa J., Towers, Mark, Griffiths, Christopher E. M., Morris, Michael, Nicolaou, Anna

“…Healthy skin depends on a unique lipid profile to form a barrier that confers protection and prevents excessive water loss, aids cell‐cell communication and…”
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Bioactive lipid mediators in skin inflammation and immunity by Kendall, Alexandra C., Nicolaou, Anna

“…The skin is the primary barrier from the outside environment, protecting the host from injury, infectious pathogens, water loss and solar ultraviolet…”
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Identification of diurnal rhythmic blood markers in bronchial asthma by Krakowiak, Karolina, Maidstone, Robert J, Chakraborty, Amlan, Kendall, Alexandra C, Nicolaou, Anna, Downton, Polly, Cristian, Andreea-Daniela, Singh, Dave, Loudon, Andrew S I, Ray, David W, Durrington, Hannah J

“…Asthma is a rhythmic inflammatory disease of the airway, regulated by the circadian clock. "Spill-over" of airway inflammation into the systemic circulation…”
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Bioactive lipids in the skin barrier mediate its functionality in health and disease by Nicolaou, Anna, Kendall, Alexandra C.

“…Our skin protects us from external threats including ultraviolet radiation, pathogens and chemicals, and prevents excessive trans-epidermal water loss. These…”
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Current insights into skin lipids and their roles in cutaneous health and disease by Nicolaou, Anna, Kendall, Alexandra C.

“…The unique and complex array of cutaneous lipids include essential components of the skin structure and signalling molecules mediating homeostasis and…”
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Topical application of lipids to correct abnormalities in the epidermal lipid barrier by Kendall, Alexandra C., Nicolaou, Anna

“…Linked Article: Danby et al. Br J Dermatol 2022; 186:875–886…”
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Lipid functions in skin: Differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model by Kendall, Alexandra C., Kiezel-Tsugunova, Magdalena, Brownbridge, Luke C., Harwood, John L., Nicolaou, Anna

“…Ceramides are important for skin health, with a multitude of species found in both dermis and epidermis. The epidermis contains linoleic acid-Ester-linked…”
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Seasonal changes in epidermal ceramides are linked to impaired barrier function in acne patients by Pappas, Apostolos, Kendall, Alexandra C., Brownbridge, Luke C., Batchvarova, Nikoleta, Nicolaou, Anna

“…Acne skin demonstrates increased transepidermal water loss (TEWL) compared with healthy skin, which may be due, in part, to altered ceramide (CER) levels. We…”
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Dynamics of the human skin mediator lipidome in response to dietary ω‐3 fatty acid supplementation by Kendall, Alexandra C., Pilkington, Suzanne M., Murphy, Sharon A., Carratore, Francesco Del, Sunarwidhi, Anggit L., Kiezel‐Tsugunova, Magdalena, Urquhart, Paula, Watson, Rachel E. B., Breitling, Rainer, Rhodes, Lesley E., Nicolaou, Anna

“…Nutritional supplementation with fish oil or ω‐3 (n‐3) polyunsaturated fatty acids (PUFAs) has potential benefits for skin inflammation. Although the…”
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Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E 2 by Newson, Justine, Motwani, Madhur P, Kendall, Alexandra C, Nicolaou, Anna, Muccioli, Giulio G, Alhouayek, Mireille, Bennett, Melanie, Van De Merwe, Rachel, James, Sarah, De Maeyer, Roel P H, Gilroy, Derek W

“…Acute inflammation is characterized by granulocyte infiltration followed by efferocytosing mononuclear phagocytes, which pave the way for inflammatory…”
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Genetic analyses of circulating PUFA-derived mediators identifies heritable dihydroxyeicosatrienoic acid species by McGurk, Kathryn A., Farrell, Laura, Kendall, Alexandra C., Keavney, Bernard D., Nicolaou, Anna

“…Estimates of heritability are the first step in identifying a trait with substantial variation due to genetic factors. Large-scale genetic analyses can…”
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