Search Results - "Kenchel, Josh"

Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes by Janzen, Evan, Shen, Yuning, Vázquez-Salazar, Alberto, Liu, Ziwei, Blanco, Celia, Kenchel, Josh, Chen, Irene A.

“…Systems of catalytic RNAs presumably gave rise to important evolutionary innovations, such as the genetic code. Such systems may exhibit particular tolerance…”
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Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness by Kenchel, Josh, Vázquez-Salazar, Alberto, Wells, Reno, Brunton, Krishna, Janzen, Evan, Schultz, Kyle M., Liu, Ziwei, Li, Weiwei, Parker, Eric T., Dworkin, Jason P., Chen, Irene A.

“…Modern life is essentially homochiral, containing D-sugars in nucleic acid backbones and L-amino acids in proteins. Since coded proteins are theorized to have…”
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Promiscuous Ribozymes and Their Proposed Role in Prebiotic Evolution by Janzen, Evan, Blanco, Celia, Peng, Huan, Kenchel, Josh, Chen, Irene A

“…The ability of enzymes, including ribozymes, to catalyze side reactions is believed to be essential to the evolution of novel biochemical activities. It has…”
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Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during Caenorhabditis elegans endoderm development by Ewe, Chee Kiang, Sommermann, Erica M., Kenchel, Josh, Flowers, Sagen E., Maduro, Morris F., Joshi, Pradeep M., Rothman, Joel H.

“…The architecture of gene regulatory networks determines the specificity and fidelity of developmental outcomes. We report that the core regulatory circuitry…”
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