Search Results - "Kemshead, J"

The international neuroblastoma risk groups (INRG): a preliminary report by Castleberry, R.P, Pritchard, J, Ambros, P, Berthold, F, Brodeur, G.M, Castel, V, Cohn, S.L, De Bernardi, B, Dicks-Mireaux, C, Frappaz, D, Haase, G.M, Haber, M, Jones, D.R, Joshi, V.V, Kaneko, M, Kemshead, J.T, Kogner, P, Lee, R.E.J, Matthay, K.K, Michon, J.M, Monclair, R, Roald, B.R, Seeger, R.C, Shaw, P.J, Shimada, H, Shuster, J.J

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The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis by JENSEN, M, ERNESTUS, K, KEMSHEAD, J, KLEHR, M, VON BERGWELT-BAILDON, M. S, SCHINKÖTHE, T, SCHULTZE, J. L, BERTHOLD, F

“…To target the neural cell adhesion molecule (NCAM, CD56) on neuroblastoma by T cell-based immunotherapy we have generated a bi-specific CD3 x NCAM antibody…”
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Targeted cytokine delivery to neuroblastoma by Dehal, P K, Embleton, M J, Kemshead, J T, Hawkins, R E

“…The aim of this study was to construct a fusion protein from the cytokine granulocyte/macrophage colony-stimulating factor (GM-CSF) and a single-chain Fv…”
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A rapid and highly selective approach to cell separations using an immunomagnetic colloid by Hancock, J P, Kemshead, J T

“…Immunomagnetic colloids have the properties of solutions and, therefore, offer distinct advantages in their ability to bind to cells as compared to larger…”
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Detection of melanoma seeding during surgical procedures – an RT-PCR based model by Warr, R.P., Zebedee, Z., Kenealy, J., Rigby, H., Kemshead, J.T.

“…Aim: It has long been suggested that malignant cells may be shed into the blood stream during any given surgical procedure for cancer. A number of studies have…”
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Neural cell adhesion molecule (NCAM) is the antigen recognized by monoclonal antibodies of similar specificity in small-cell lung carcinoma and neuroblastoma by Patel, K, Moore, S E, Dickson, G, Rossell, R J, Beverley, P C, Kemshead, J T, Walsh, F S

“…We describe reagents from 2 workshops which had been identified as recognizing the same or very similar antigens based on their tissue reactivity. Examination…”
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The bi‐specific CD3 × NCAM antibody: a model to preactivate T cells prior to tumour cell lysis by JENSEN, M., ERNESTUS, K., KEMSHEAD, J., KLEHR, M., VON BERGWELT‐BAILDON, M. S., SCHINKÖTHE, T., SCHULTZE, J. L., BERTHOLD, F.

“…SUMMARY To target the neural cell adhesion molecule (NCAM, CD56) on neuroblastoma by T cell‐based immunotherapy we have generated a bi‐specific CD3 × NCAM…”
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Ubiquitous Cell-Surface Glycoprotein on Tumor Cells is Proliferation-Associated Receptor for Transferrin by Sutherland, Robert, Delia, Domenico, Schneider, Claudio, Newman, Roland, Kemshead, John, Greaves, Melvyn

“…A murine monoclonal antibody (OKT9) raised against human leukemic cells binds to a wide variety of leukemia and tumor cell lines and to a minority of leukemia…”
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A pilot study of the treatment of patients with recurrent malignant gliomas with intratumoral yttrium-90 radioimmunoconjugates by Hopkins, K., Chandler, C., Bullimore, J., Sandeman, D., Coakham, H., Kemshead, J.T.

“…A pilot study of the treatment of patients with relapsed malignant gliomas with direct intratumoral injections of yttrium-90 ( 90Y) radioimmunoconjugates has…”
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Sub‐lethal effects of exposing the human melanoma cell line Skmel−23 to 532 nm laser light by Zhu, Ning Wen, Kenealy, John, Burd, Andrew, Gradidge, Terry, Warr, Robert, Rigby, Howard S., Kemshead, John T.

“…The human melanoma cell line SKmel‐23 has been used to investigate the sub‐lethal damage that can occur as a result of exposing melanin containing cells to…”
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Dose escalation with repeated intrathecal injections of 131I-labelled MAbs for the treatment of central nervous system malignancies by KEMSHEAD, J. T, HOPKINS, K, PIZER, B, PAPANASTASSIOU, V, COAKHAM, H, BULLIMORE, J, CHANDLER, C

“…We have previously demonstrated a 33% response rate in patients with primitive neurectodermal tumours after the direct injection of 131I-monoclonal antibodies…”
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L1 adhesion molecule on human lymphocytes and monocytes: expression and involvement in binding to alpha v beta 3 integrin by Ebeling, O, Duczmal, A, Aigner, S, Geiger, C, Schöllhammer, S, Kemshead, J T, Möller, P, Schwartz-Albiez, R, Altevogt, P

“…The L1 adhesion molecule is a member of the immunoglobulin (Ig) superfamily initially identified in the nervous system which contains six Ig-like domains…”
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Meta-iodobenzylguanidine (mIBG) uptake and storage in the human neuroblastoma cell line SK-N-BE(2C) by Lashford, L S, Hancock, J P, Kemshead, J T

“…Whilst many human neuroblastoma cell lines have been studied to see if they are capable of taking up mIBG, few appear to have this ability. This contrasts…”
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The detection of tyrosinase mRNA in peripheral blood samples is unlikely to aid in the management of patients with localised malignant melanoma by Warr, R.P, Zebedee, Z, Kenealy, J, Rigby, H, Kemshead, J.T

“…A number of authors have reported the detection of tyrosinase mRNA in the peripheral blood of patients with malignant melanoma using the reverse transcription…”
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Magnetic microspheres and monoclonal antibodies for the depletion of neuroblastoma cells from bone marrow: Experiences, improvements and observations by KEMSHEAD, J. T, HEATH, L, GIBSON, F. M, KATZ, F, RICHMOND, F, TRELEAVEN, J, UGELSTAD, J

“…Improvements to the original procedure of using a panel of monoclonal antibodies and magnetic microspheres for the depletion of tumour cells from bone marrow…”
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Uses and Limitations of Monoclonal Antibodies (MoAbs) in the Treatment of Malignant Disease: A Review by Kemshead, J T, Hopkins, K

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A model to estimate the dose to tumour following intracavity administration of radioimmunoconjugates to patients with malignant gliomas by Hopkins, K, Papanastassiou, V, Zananiri, F A, Kemshead, J T

“…Patients who have relapsed following primary treatment for malignant glioma and have undergone further surgical debulking have been treated with an anti-human…”
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The epidermal growth factor receptor in glioblastoma: genomic amplification, protein expression, and patient survival data in a therapeutic trial by Schober, R, Bilzer, T, Waha, A, Reifenberger, G, Wechsler, W, von Deimling, A, Wiestler, O D, Westphal, M, Kemshead, J T, Vega, F

“…Human glioblastomas were evaluated for overexpression of the epidermal growth factor receptor (EGFR) in a therapeutic trial with the anti-EGFR antibody EMD…”
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Phase I/II study of iodine 131 metaiodobenzylguanidine in chemoresistant neuroblastoma: a United Kingdom Children's Cancer Study Group investigation by Lashford, L S, Lewis, I J, Fielding, S L, Flower, M A, Meller, S, Kemshead, J T, Ackery, D

“…The goal of this study was to evaluate the toxicity of iodine 131 metaiodobenzylguanidine (mIBG) in metastatic neuroblastoma. A multicenter phase I study of…”
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A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm by BOURNE, S. P, PATEL, K, POPHAM, C. J, COAKHAM, H. B, KEMSHEAD, J. T

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