Search Results - "Kempton, Hannah R."

Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing by Xu, Xiaoshu, Chemparathy, Augustine, Zeng, Leiping, Kempton, Hannah R., Shang, Stephen, Nakamura, Muneaki, Qi, Lei S.

“…Compact and versatile CRISPR-Cas systems will enable genome engineering applications through high-efficiency delivery in a wide variety of contexts. Here, we…”
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CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling by Platt, Randall J., Chen, Sidi, Zhou, Yang, Yim, Michael J., Swiech, Lukasz, Kempton, Hannah R., Dahlman, James E., Parnas, Oren, Eisenhaure, Thomas M., Jovanovic, Marko, Graham, Daniel B., Jhunjhunwala, Siddharth, Heidenreich, Matthias, Xavier, Ramnik J., Langer, Robert, Anderson, Daniel G., Hacohen, Nir, Regev, Aviv, Feng, Guoping, Sharp, Phillip A., Zhang, Feng

“…CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we…”
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Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits by Platt, Randall J., Zhou, Yang, Slaymaker, Ian M., Shetty, Ashwin S., Weisbach, Niels R., Kim, Jin-Ah, Sharma, Jitendra, Desai, Mitul, Sood, Sabina, Kempton, Hannah R., Crabtree, Gerald R., Feng, Guoping, Zhang, Feng

“…Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models can provide an entry point to studying the molecular underpinnings of…”
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Multiple Input Sensing and Signal Integration Using a Split Cas12a System by Kempton, Hannah R., Goudy, Laine E., Love, Kasey S., Qi, Lei S.

“…The ability to integrate biological signals and execute a functional response when appropriate is critical for sophisticated cell engineering using synthetic…”
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When genome editing goes off-target by Kempton, Hannah R, Qi, Lei S

“…Detecting unintended mutations could improve DNA-editing strategies Editing DNA in eukaryotic cells with CRISPR-based systems has revolutionized the genome…”
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Scalable biological signal recording in mammalian cells using Cas12a base editors by Kempton, Hannah R., Love, Kasey S., Guo, Lucie Y., Qi, Lei S.

“…Biological signal recording enables the study of molecular inputs experienced throughout cellular history. However, current methods are limited in their…”
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Multiplexed genome regulation in vivo with hyper-efficient Cas12a by Guo, Lucie Y., Bian, Jing, Davis, Alexander E., Liu, Pingting, Kempton, Hannah R., Zhang, Xiaowei, Chemparathy, Augustine, Gu, Baokun, Lin, Xueqiu, Rane, Draven A., Xu, Xiaoshu, Jamiolkowski, Ryan M., Hu, Yang, Wang, Sui, Qi, Lei S.

“…Multiplexed modulation of endogenous genes is crucial for sophisticated gene therapy and cell engineering. CRISPR–Cas12a systems enable versatile…”
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Using Coronary Artery Calcium Scoring as Preventative Health Tool to Reduce the High Burden of Cardiovascular Disease in Indigenous Australians by Kempton, Hannah R., Bemand, Timothy, Bart, Nikki K., Suttie, Joseph J.

“…Indigenous Australians suffer higher rates of ischaemic heart disease resulting in premature mortality. Despite this, Indigenous Australians undergo less…”
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Recovery of Chinese hamster ovary host cell proteins for proteomic analysis by Valente, Kristin N., Schaefer, Amy K., Kempton, Hannah R., Lenhoff, Abraham M., Lee, Kelvin H.

“…Identification and characterization of Chinese hamster ovary (CHO) host cell protein (HCP) impurities by proteomic techniques can aid bioprocess design and…”
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