Search Results - "Kempton, Amber"
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Systemic γ-sarcoglycan AAV gene transfer results in dose-dependent correction of muscle deficits in the LGMD 2C/R5 mouse model
Published in Molecular therapy. Methods & clinical development (09-03-2023)“…Limb-girdle muscular dystrophy (LGMD) type 2C/R5 results from mutations in the γ-sarcoglycan (SGCG) gene and is characterized by muscle weakness and…”
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Dysfunction of the β2-spectrin-based pathway in human heart failure
Published in American journal of physiology. Heart and circulatory physiology (01-06-2016)“…β2-Spectrin is critical for integrating membrane and cytoskeletal domains in excitable and nonexcitable cells. The role of β2-spectrin for vertebrate function…”
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Pazopanib for renal cell carcinoma leads to elevated mean arterial pressures in a murine model
Published in Clinical and experimental hypertension (1993) (18-08-2018)“…Background: In the setting of metastatic RCC (mRCC), pazopanib is approved as first line therapy. Unfortunately treatment may lead to cardiotoxicity such as…”
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Altered regulation of cardiac ankyrin repeat protein in heart failure
Published in Heliyon (01-01-2018)“…Left ventricular assist devices (LVADs) have revolutionized and improved the care of the sickest heart failure (HF) patients, and it is imperative that they…”
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Evaluating Pharmacology and Efficacy of Delandistrogene Moxeparvovec in Young and Aged DMDmdx Rats (P3-8.008)
Published in Neurology (25-04-2023)“…Abstract only…”
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Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non‐cell autonomous developmental mechanisms
Published in Brain pathology (Zurich, Switzerland) (01-01-2021)“…Congenital central hypoventilation syndrome (CCHS) represents a rare genetic disorder usually caused by mutations in the homeodomain transcription factor…”
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Abstract 20284: Cardiac Ankyrin Repeat Protein Expression Is Impacted By Ventricular Loading Conditions In Chronic Heart Failure
Published in Circulation (New York, N.Y.) (11-11-2016)“…IntroductionAnkyrin repeat domain 1 (ANKRD1), the gene encoding CARP, a transcription co-factor that translocates to the nucleus in response to mechanical…”
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