Search Results - "Kempná, Petra"

Why Boys Will Be Boys: Two Pathways of Fetal Testicular Androgen Biosynthesis Are Needed for Male Sexual Differentiation by Flück, Christa E., Meyer-Böni, Monika, Pandey, Amit V., Kempná, Petra, Miller, Walter L., Schoenle, Eugen J., Biason-Lauber, Anna

“…Human sexual determination is initiated by a cascade of genes that lead to the development of the fetal gonad. Whereas development of the female external…”
Get full text

Modulation of Human CYP19A1 Activity by Mutant NADPH P450 Oxidoreductase by Pandey, Amit V, Kempná, Petra, Hofer, Gaby, Mullis, Primus E, Flück, Christa E

“…Mutations in NADPH P450 oxidoreductase (POR) cause a broad spectrum of human disease with abnormalities in steroidogenesis. We have studied the impact of P450…”
Get full text

Impact of Differential P450c17 Phosphorylation by cAMP Stimulation and by Starvation Conditions on Enzyme Activities and Androgen Production in NCI-H295R Cells by Kempná, Petra, Hirsch, Andrea, Hofer, Gaby, Mullis, Primus E, Flück, Christa E

“…CYP17A1 plays a pivotal role in the biosynthesis of androgens in the adrenals and the gonads. Although this enzyme catalyzes two different reactions on one…”
Get full text

Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents by Missaghian, Elika, Kempná, Petra, Dick, Bernhard, Hirsch, Andrea, Alikhani-Koupaei, Rasoul, Jégou, Bernard, Mullis, Primus E, Frey, Brigitte M, Flück, Christa E

“…The CYP17A1 gene is the qualitative regulator of steroidogenesis. Depending on the presence or absence of CYP17 activities mineralocorticoids, glucocorticoids…”
Get full text

Pioglitazone inhibits androgen production in NCI-H295R cells by regulating gene expression of CYP17 and HSD3B2 by Kempná, Petra, Hofer, Gaby, Mullis, Primus E, Flück, Christa E

“…Thiazolidinediones (TZDs) such as pioglitazone and rosiglitazone are widely used as insulin sensitizers in the treatment of type 2 diabetes. In diabetic women…”
Get more information

Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells by Hirsch, Andrea, Hahn, Dagmar, Kempná, Petra, Hofer, Gaby, Mullis, Primus E, Nuoffer, Jean-Marc, Flück, Christa E

“…Regulation of human androgen biosynthesis is poorly understood. However, detailed knowledge is needed to eventually solve disorders with androgen dysbalance…”
Get full text

Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3β-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities by Samandari, Elika, Kempná, Petra, Nuoffer, Jean-Marc, Hofer, Gaby, Mullis, Primus E, Flück, Christa E

“…The human adrenal cortex produces mineralocorticoids, glucocorticoids, and androgens in a species-specific, hormonally regulated, zone-specific, and…”
Get full text

Why Boys Will Be Boys: Two Pathways of Fetal Testicular Androgen Biosynthesis Are Needed for Male Sexual Differentiation by Flück, Christa E., Meyer-Böni, Monika, Pandey, Amit V., Kempná, Petra, Miller, Walter L., Schoenle, Eugen J., Biason-Lauber, Anna

Get full text

Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells by Freedman, Bethany D., Kempna, Petra Bukovac, Carlone, Diana L., Shah, Manasvi S., Guagliardo, Nick A., Barrett, Paula Q., Gomez-Sanchez, Celso E., Majzoub, Joseph A., Breault, David T.

“…Lineage conversion of differentiated cells in response to hormonal feedback has yet to be described. To investigate this, we studied the adrenal cortex, which…”
Get full text

Regulation of androgen biosynthesis – A short review and preliminary results from the hyperandrogenic starvation NCI-H295R cell model by Kempná, Petra, Marti, Nesa, Udhane, Sameer, Flück, Christa E.

“…•Androgen production is well characterized biochemically but its regulation is poorly understood.•CYP17A1, POR, CYB5, HSD3B2, SULT2A1 and AKR1C3 are…”
Get full text

Metformin Inhibits Human Androgen Production by Regulating Steroidogenic Enzymes HSD3B2 and CYP17A1 and Complex I Activity of the Respiratory Chain by Hirsch, Andrea, Hahn, Dagmar, Kempná, Petra, Hofer, Gaby, Nuoffer, Jean-Marc, Mullis, Primus E, Flück, Christa E

“…Metformin is treatment of choice for the metabolic consequences seen in polycystic ovary syndrome for its insulin-sensitizing and androgen-lowering properties…”
Get full text

Vitamin E Mediates Cell Signaling and Regulation of Gene Expression by AZZI, ANGELO, GYSIN, RENÉ, KEMPNÁ, PETRA, MUNTEANU, ADELINA, NEGIS, YESIM, VILLACORTA, LUIS, VISARIUS, THERESA, ZINGG, JEAN-MARC

“…: α‐Tocopherol modulates two major signal transduction pathways centered on protein kinase C and phosphatidylinositol 3‐kinase. Changes in the activity of…”
Get full text

Differential regulation of human 3β-hydroxysteroid dehydrogenase type 2 for steroid hormone biosynthesis by starvation and cyclic AMP stimulation: studies in the human adrenal NCI-H295R cell model by Udhane, Sameer, Kempna, Petra, Hofer, Gaby, Mullis, Primus E, Flück, Christa E

“…Human steroid biosynthesis depends on a specifically regulated cascade of enzymes including 3β-hydroxysteroid dehydrogenases (HSD3Bs). Type 2 HSD3B catalyzes…”
Get full text

Adrenal gland development and defects by Kempná, Petra, PhD, Flück, Christa E., MD

“…The network regulating human adrenal development is complex. Studies of patients with adrenal insufficiency due to gene mutations established a central role…”
Get full text

The Regulation of Cell Therapy and Gene Therapy Products in Switzerland by Bukovac, Petra Kempná, Hauser, Michel, Lottaz, Daniel, Marti, Andreas, Schmitt, Iris, Schochat, Thomas

“…This chapter describes the regulation of cell and gene therapy products (CGTPs) in Switzerland and its legal basis. The Swiss Agency for Therapeutic Products,…”
Get more information

Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathway by Kempná, Petra, Reiter, Elke, Arock, Michel, Azzi, Angelo, Zingg, Jean-Marc

“…The effects of four natural tocopherols on the proliferation and signaling pathways were examined in the human mastocytoma cell line (HMC-1). The four…”
Get full text

The delivery of ADP/ATP carrier protein to mitochondria probed by fusions with green fluorescent protein and β-galactosidase by Polčicová, Katarı́na, Kempná, Petra, Šabová, L’udmila, Gavurnı́ková, Gabriela, Polčic, Peter, Kolarov, Jordan

“…The import of proteins into mitochondria is an essential process, largely investigated in vitro with isolated mitochondria and radioactively labeled…”
Get full text

Alternative splicing and gene polymorphism of the human TAP3/SEC14L4 gene by Kempna, Petra, Ricciarelli, Roberta, Azzi, Angelo, Zingg, Jean-Marc

“…Three closely related human SEC14p-like proteins (hTAP1, hTAP2, hTAP3, or SEC14L2, SEC14L3, SEC14L4, respectively) have been described that are related to the…”
Get full text

Recombinant SEC14-like proteins (TAP) possess GTPase activity by Habermehl, Daniel, Kempna, Petra, Azzi, Angelo, Zingg, Jean-Marc

“…The three human SEC14-like proteins TAP1, TAP2, and TAP3 were expressed in Escherichia coli and purified by means of an amino-terminal His-tag. The recombinant…”
Get full text

Inhibition of HMC-1 Mast Cell Proliferation by Vitamin E by Kempná, Petra, Reiter, Elke, Arock, Michel, Azzi, Angelo, Zingg, Jean-Marc

“…The effects of four natural tocopherols on the proliferation and signaling pathways were examined in the human mastocytoma cell line (HMC-1). The four…”
Get full text