Search Results - "Kempka, G"

Molecular multiple endpoint embryonic stem cell test—a possible approach to test for the teratogenic potential of compounds by zur Nieden, N.I, Kempka, G, Ahr, H.J

“…The embryonic stem cell test (EST) examines the cytotoxicity of chemical compounds on embryonic stem (ES) cells and 3T3.A31 fibroblasts. Additionally, the EST…”
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Design and Optimization of 20-O-Linked Camptothecin Glycoconjugates as Anticancer Agents by Lerchen, Hans-Georg, Baumgarten, Joerg, von dem Bruch, Karsten, Lehmann, Thomas E, Sperzel, Michael, Kempka, Grazyna, Fiebig, Heinz-Herbert

“…To improve the biological profile of 20(S)-camptothecin, a novel class of 20-O-linked camptothecin glycoconjugates has been designed for preferential cellular…”
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3-D Coculture of Hepatic Sinusoidal Cells with Primary Hepatocytes—Design of an Organotypical Model by Bader, A., Knop, E., Kern, A., Böker, K., Frühauf, N., Crome, O., Esselmann, H., Pape, C., Kempka, G., Sewing, K.-Fr

“…Models for cocultures of parenchymal (PC) and nonparenchymal cells (NPC) of the liver relied on mixing the cells in a two-dimensional configuration or on…”
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Molecular markers in embryonic stem cells by zur Nieden, N.I, Ruf, L.J, Kempka, G, Hildebrand, H, Ahr, H.J

“…Embryonic stem cells are pluripotent cells derived from mouse blastocysts, which have the capacity to differentiate in vitro into a wide variety of cell types…”
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Determination of Apoptosis in Primary Rat Hepatocytes by Real-time Quantitative PCR (TaqMan PCR) by Hildebrand, H., Kempka, G., Mahnke, A.

“…Primary hepatocytes in collagen gel sandwich culture are a well suited model for studying effects like xenobiotic metabolism, hepatotoxicity, apoptosis, and…”
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Effects of fluoroquinolones and glucocorticoids on cultivated tendon cells in vitro by Kempka, G., Ahr, H.J., Rüther, W., Schlüter, G.

“…Achilles tendon rupture is known to occur after administration of various drugs to patients. It is also reported to occur after treatment with fluoroquinolone…”
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Chondrotoxicity of quinolones in vivo and in vitro by HILDEBRAND, H, KEMPKA, G, SCHLÜTER, G, SCHMIDT, M

“…Chondrotoxicity is a rare toxicological finding which is observed in dogs after administration of quinolone antibacterials. To study this effect chondrocytes…”
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In vitro differentiation of embryonic stem cells into mineralized osteoblasts by zur Nieden, Nicole I., Kempka, Grazyna, Ahr, Hans J.

“…Embryonic stem cells are pluripotent cells derived from the inner cell mass of mouse blastocysts that have been shown to differentiate spontaneously into cell…”
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An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture by Hildebrand, H, Schmidt, U, Kempka, G, Jacob, R, Ahr, H.J, Ebener, C, Goretzki, P.E, Bader, A

“…Peroxisome proliferators comprise a group of structurally diverse chemicals which share as a common biologic effect the induction of peroxisomal fatty acid…”
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Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages by zur Nieden, Nicole I, Kempka, Grazyna, Rancourt, Derrick E, Ahr, Hans-Jürgen

“…Recently, tissue engineering has merged with stem cell technology with interest to develop new sources of transplantable material for injury or disease…”
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Evaluation of phototoxic and photoallergic potentials of 13 compounds by different in vitro and in vivo methods by Neumann, Norbert J., Blotz, Andrea, Wasinska-Kempka, Grazyna, Rosenbruch, Martin, Lehmann, Percy, Ahr, Hans Jürgen, Vohr, Hans-Werner

“…Phototoxic side effects of pharmaceutical and cosmetic products are of increasing concern for patients, dermatologists and the chemical industry. Moreover, the…”
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375 Gene expression analysis of galactosamine-induced hepatotoxicity in-vivo and in-vitro by Hildebrand, H., Kempka, G., Ellinger, H., Stuart, B., Wahle, B., Ahr, H.J.

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Respiratory hypersensitivity to trimellitic anhydride in Brown Norway Rats: a comparison of endpoints by Pauluhn, Jürgen, Eidmann, Petra, Freyberger, Alexius, Wasinska-Kempka, Grazyna, Vohr, Hans-Werner

“…A rat bioassay has been developed to provide an objective approach for the identification and classification of respiratory allergy using trimellitic anhydride…”
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A membrane-associated form of C-reactive protein is the galactose- specific particle receptor on rat liver macrophages by Kempka, G, Roos, PH, Kolb-Bachofen, V

“…Rat liver macrophages express a galactose-specific receptor which mediates endocytosis of particles or neuraminidase-treated blood cells. From rat serum we now…”
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Binding, uptake, and transcytosis of ligands for mannose-specific receptors in rat liver: an electron microscopic study by Kempka, G, Kolb-Bachofen, V

“…We have investigated the initial distribution of mannose-specific binding sites in rat liver as well as the uptake and transcytosis pathways of ligands for…”
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Galactose-specific receptors on liver cells. I. Hepatocyte and liver macrophage receptors differ in their membrane anchorage by Kempka, G, Kolb-Bachofen, V

“…Colloidal gold particles coated with asialoglycoproteins are bound by hepatocytes as well as by liver macrophages. Binding by both cell types is inhibited by…”
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