Search Results - "Kempen, Diederik H.R"

Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration by Kempen, Diederik H.R, Lu, Lichun, Heijink, Andras, Hefferan, Theresa E, Creemers, Laura B, Maran, Avudaiappan, Yaszemski, Michael J, Dhert, Wouter J.A

“…Abstract Bone regeneration is a coordinated cascade of events regulated by several cytokines and growth factors. Angiogenic growth factors are predominantly…”
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Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering by Kempen, Diederik H.R, Lu, Lichun, Hefferan, Teresa E, Creemers, Laura B, Maran, Avudaiappan, Classic, Kelly L, Dhert, Wouter J.A, Yaszemski, Michael J

“…Abstract In this study, we investigated the in vitro and in vivo biological activities of bone morphogenetic protein 2 (BMP-2) released from four sustained…”
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Growth factor interactions in bone regeneration by Kempen, Diederik H R, Creemers, Laura B, Alblas, Jacqueline, Lu, Lichun, Verbout, Abraham J, Yaszemski, Michael J, Dhert, Wouter J A

“…Bone regeneration is a complex process regulated by a large number of bioactive molecules. Many growth factors and cytokines involved in the natural process of…”
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Efficacy of a Standalone Microporous Ceramic Versus Autograft in Instrumented Posterolateral Spinal Fusion: A Multicenter, Randomized, Intrapatient Controlled, Noninferiority Trial by Lehr, A. Mechteld, Oner, F. Cumhur, Delawi, Diyar, Stellato, Rebecca K., Hoebink, Eric A., Kempen, Diederik H.R., van Susante, Job L.C., Castelein, René M., Kruyt, Moyo C.

“…STUDY DESIGN.in the rest of the article written as patient- and observer-blinded, multicenter, randomized, intrapatient controlled, noninferiority trial…”
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Molecularly Engineered Biodegradable Polymer Networks with a Wide Range of Stiffness for Bone and Peripheral Nerve Regeneration by Wang, Shanfeng, Kempen, Diederik H. R., de Ruiter, Godard C. W., Cai, Lei, Spinner, Robert J., Windebank, Anthony J., Yaszemski, Michael J., Lu, Lichun

“…To satisfy different mechanical requirements in hard and soft tissue replacements, a series of biodegradable and crosslinkable copolymers of poly(propylene…”
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Reliability and Validity of the Adapted Dutch Version of the Early-Onset Scoliosis-24-Item Questionnaire (EOSQ-24) by Wijdicks, Sebastiaan P.J., Dompeling, Stephanie D., de Reuver, Steven, Kempen, Diederik H.R., Castelein, René M., Kruyt, Moyo C.

“…Translation and validation of the Early Onset Scoliosis-24 Questionnaire (EOSQ-24). To cross-culturally adapt the English version of the EOSQ-24 to the Dutch…”
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Increasing Fusion Rate Between 1 and 2 Years After Instrumented Posterolateral Spinal Fusion and the Role of Bone Grafting by Lehr, A. Mechteld, Oner, F. Cumhur, Delawi, Diyar, Stellato, Rebecca K., Hoebink, Eric A., Kempen, Diederik H.R., van Susante, Job L.C., Castelein, René M., Kruyt, Moyo C.

“…STUDY DESIGN.Two-year clinical and radiographic follow-up of a double-blind, multicenter, randomized, intra-patient controlled, non-inferiority trial comparing…”
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Spinal Growth in Patients With Juvenile Idiopathic Scoliosis Treated With Boston Brace: A Retrospective Study by Heemskerk, Johan L., Wijdicks, Sebastiaan P.J., Altena, Mark C., Castelein, René M., Kruyt, Moyo C., Kempen, Diederik H.R.

“…STUDY DESIGN.Retrospective comparative cohort. OBJECTIVE.The aim of this study was to determine whether spinal growth is restricted by brace treatment in…”
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Prevalence and risk factors for neural axis anomalies in idiopathic scoliosis: a systematic review by Heemskerk, Johan L., Kruyt, Moyo C., Colo, Dino, Castelein, René M., Kempen, Diederik H.R.

“…There is ongoing controversy about the routine use of magnetic resonance imaging (MRI) preoperatively in patients with presumed idiopathic scoliosis (IS)…”
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Effect of different sustained bone morphogenetic protein-2 release kinetics on bone formation in poly(propylene fumarate) scaffolds by Olthof, Maurits G L, Kempen, Diederik H R, Herrick, James L, Yaszemski, Michael J, Dhert, Wouter J A, Lu, Lichun

“…To investigate the effect of sustained bone morphogenetic protein-2 (BMP-2) release kinetics on bone formation in poly(propylene fumarate) (PPF) scaffolds,…”
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Patients Cannot Reliably Distinguish the Iliac Crest Bone Graft Donor Site From the Contralateral Side After Lumbar Spine Fusion: A Patient-blinded Randomized Controlled Trial by Lehr, A. Mechteld, Oner, F. Cumhur, Hoebink, Eric A., Kempen, Diederik H.R., van Susante, Job L.C., Castelein, René M., Kruyt, Moyo C.

“…STUDY DESIGN.A multicenter, randomized, intrapatient controlled trial. OBJECTIVE.This study investigated whether lumbar fusion patients blinded to the harvest…”
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The roles of matrix polymer crystallinity and hydroxyapatite nanoparticles in modulating material properties of photo-crosslinked composites and bone marrow stromal cell responses by Wang, Shanfeng, Kempen, Diederik H.R, Yaszemski, Michael J, Lu, Lichun

“…Abstract Two poly(ε-caprolactone fumarate)s (PCLFs) with distinct physical properties have been employed to prepare nanocomposites with hydroxyapatite (HA)…”
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Prosthetic Joint Infection and Wound Leakage After the Introduction of Intraoperative Wound Irrigation With a Chlorhexidine-Cetrimide Solution: A Large-Scale Before-After Study by Willigenburg, Nienke W., Yesilkaya, Fatih, Rutgers, Marijn, Moojen, Dirk Jan F., Poolman, Rudolf W., Kempen, Diederik H.R.

“…Intraoperative chlorhexidine irrigation could be a valuable additive to systemic antibiotics to prevent infections after total joint arthroplasties. However,…”
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Non-invasive monitoring of BMP-2 retention and bone formation in composites for bone tissue engineering using SPECT/CT and scintillation probes by Kempen, Diederik H.R., Yaszemski, Michael J., Heijink, Andras, Hefferan, Theresa E., Creemers, Laura B., Britson, Jason, Maran, Avudaiappan, Classic, Kelly L., Dhert, Wouter J.A., Lu, Lichun

“…Non-invasive imaging can provide essential information for the optimization of new drug delivery-based bone regeneration strategies to repair damaged or…”
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Enhanced bone morphogenetic protein-2-induced ectopic and orthotopic bone formation by intermittent parathyroid hormone (1-34) administration by Kempen, Diederik H R, Lu, Lichun, Hefferan, Theresa E, Creemers, Laura B, Heijink, Andras, Maran, Avudaiappan, Dhert, Wouter J A, Yaszemski, Michael J

“…Bone morphogenetic proteins (BMPs) play a central role in local bone regeneration strategies, whereas the anabolic features of parathyroid hormone (PTH) are…”
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Effect of autologous bone marrow stromal cell seeding and bone morphogenetic protein-2 delivery on ectopic bone formation in a microsphere/poly(propylene fumarate) composite by Kempen, Diederik H R, Kruyt, Moyo C, Lu, Lichun, Wilson, Clayton E, Florschutz, Anthony V, Creemers, Laura B, Yaszemski, Michael J, Dhert, Wouter J A

“…A biodegradable microsphere/scaffold composite based on the synthetic polymer poly(propylene fumarate) (PPF) holds promise as a scaffold for cell growth and…”
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Response to the letter to the editor regarding, "Pulmonary function in children and adolescents with untreated idiopathic scoliosis: a systematic review with meta-regression analysis by Kempen, Diederik H.R., Willigenburg, Ninke W.

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Health-related quality of life of adult, non-surgically treated patients with idiopathic scoliosis and curves above 45°: a cross-sectional study at an average follow-up of 30 years by Brandwijk, Anne C., Heemskerk, Johan L., Willigenburg, Nienke W., Altena, Mark C., Kempen, Diederik H. R.

“…Background context Previous studies on the natural history of moderate to severe idiopathic scoliosis show contradictory results. Some studies reported an…”
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Clinical Utility of An Intervertebral Motion Metric for Deciding on the Addition of Instrumented Fusion in Degenerative Spondylolisthesis by Reijmer, Joey F H, de Jong, Lex D, Kempen, Diederik H R, Arts, Mark P, van Susante, Job L C

“…A prospective single-arm clinical study. To explore the clinical utility of an intervertebral motion metric by determining the proportion of patients for whom…”
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Efficacy of Biphasic Calcium Phosphate Ceramic With a Needle-Shaped Surface Topography Versus Autograft in Instrumented Posterolateral Spinal Fusion by Stempels, Hilde W., Lehr, A. Mechteld, Delawi, Diyar, Hoebink, Eric A., Wiljouw, Inge A.A.A., Kempen, Diederik H.R., van Susante, Job L.C., Kruyt, Moyo C.

“…A multicenter randomized controlled noninferiority trial with intrapatient comparisons.STUDY DESIGNA multicenter randomized controlled noninferiority trial…”
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