Search Results - "Kemp, Rowena"

Vascular Cytochrome P450 4A Expression and 20-Hydroxyeicosatetraenoic Acid Synthesis Contribute to Endothelial Dysfunction in Androgen-Induced Hypertension by Singh, Harpreet, Cheng, Jennifer, Deng, Huan, Kemp, Rowena, Ishizuka, Tsuneo, Nasjletti, Alberto, Schwartzman, Michal Laniado

“…Epidemiological evidence suggests a role for sex-dependent mechanisms in the pathophysiology of hypertension. It has been shown that 5α-dihydrotestosterone…”
Get full text

Smooth Muscle—Specific Expression of CYP4A1 Induces Endothelial Sprouting in Renal Arterial Microvessels by Jiang, Miao, Mezentsev, Alexandre, Kemp, Rowena, Byun, Kihwan, Falck, John R, Miano, Joseph M, Nasjletti, Alberto, Abraham, Nader G, Laniado-Schwartzman, Michal

“…ABSTRACT—Cytochrome P450 (CYP) 4A1 has been characterized as the most efficient arachidonic acid ω-hydroxylase catalyzing the formation of…”
Get full text

Urinary proteomic analysis of chronic allograft nephropathy by O'Riordan, Edmond, Orlova, Tatyana N., Mendelev, Natalia, Patschan, Daniel, Kemp, Rowena, Chander, Praveen N., Hu, Rena, Hao, Gang, Gross, Steven S., Iozzo, Renato V., Delaney, Veronica, Goligorsky, Michael S.

“…The pathogenesis of progressive renal allograft injury, which is termed chronic allograft nephropathy (CAN), remains obscure and is currently defined by…”
Get full text

Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels by Mezentsev, Alexandre, Mastyugin, Vladimir, Seta, Francesca, Ashkar, Silvia, Kemp, Rowena, Reddy, D Sudarshan, Falck, John R, Dunn, Michael W, Laniado-Schwartzman, Michal

“…Injury to the ocular surface induces the production of the corneal epithelial-derived 12-hydroxyeicosatetrienoic acid (12-HETrE), which exhibits stereospecific…”
Get more information

Urinary Biomarkers of AKI and Mortality 3 Years after Cardiac Surgery by COCA, Steven G, GARG, Amit X, THIESSEN-PHILBROOK, Heather, KOYNER, Jay L, PATEL, Uptal D, KRUMHOLZ, Harlan M, SHLIPAK, Michael G, PARIKH, Chirag R

“…Urinary biomarkers of AKI provide prognostic value for in-hospital outcomes, but little is known about their association with longer-term mortality after…”
Get full text

Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR by Koyner, Jay L., MD, Coca, Steven G., DO, MS, Thiessen-Philbrook, Heather, MMath, Patel, Uptal D., MD, Shlipak, Michael G., MD, MPH, Garg, Amit X., MD, PhD, Parikh, Chirag R., MD, PhD

“…Background The interaction between baseline kidney function and the performance of biomarkers of acute kidney injury (AKI) on the development of AKI is…”
Get full text

Epoxyeicosatrienoic Acid Activates BK Channels in the Cortical Collecting Duct by PENG SUN, WEN LIU, LIN, Dao-Hong, PENG YUE, KEMP, Rowena, SATLIN, Lisa M, WANG, Wen-Hui

“…The cortical collecting duct (CCD), which is involved in renal potassium (K) excretion, expresses cytochrome P450 (CYP)-epoxygenase. Here, we examined the…”
Get full text

Endothelial Dysfunction and Hypertension in Rats Transduced With CYP4A2 Adenovirus by Wang, Ji-Shi, Singh, Harpreet, Zhang, Frank, Ishizuka, Tsuneo, Deng, Huan, Kemp, Rowena, Wolin, Michael S, Hintze, Thomas H, Abraham, Nader G, Nasjletti, Alberto, Laniado-Schwartzman, Michal

“…Vascular cytochrome P450 (CYP) 4A enzymes catalyze the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), an eicosanoid which participates in the…”
Get full text

Effects of Exogenous Heme on Renal Function: Role of Heme Oxygenase and Cyclooxygenase by Rodriguez, Francisca, Kemp, Rowena, Balazy, Michael, Nasjletti, Alberto

“…ABSTRACT—We examined the effects of heme administration (15 mg/kg IV) on indexes of renal carbon monoxide production and contrasted the renal functional…”
Get full text

Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways by Wei, Yuan, Lin, Dao-Hong, Kemp, Rowena, Yaddanapudi, Ganesh S S, Nasjletti, Alberto, Falck, John R, Wang, Wen-Hui

“…We used the patch-clamp technique to study the effect of arachidonic acid (AA) on epithelial Na channels (ENaC) in the rat cortical collecting duct (CCD)…”
Get full text

Inhibition of VEGF expression and corneal neovascularization by siRNA targeting cytochrome P450 4B1 by Seta, Francesca, Patil, Kiran, Bellner, Lars, Mezentsev, Alexandre, Kemp, Rowena, Dunn, Michael W., Schwartzman, Michal Laniado

“…Injury to the cornea leads to formation of mediators that initiate and amplify inflammatory responses and neovascularization. Among these are lipid mediators…”
Get full text

Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC by Sun, Peng, Lin, Dao-Hong, Wang, Tong, Babilonia, Elisa, Wang, Zhijian, Jin, Yan, Kemp, Rowena, Nasjletti, Alberto, Wang, Wen-Hui

“…We previously demonstrated that arachidonic acid (AA) inhibits epithelial Na channels (ENaC) through the cytochrome P-450 (CYP) epoxygenase-dependent pathway…”
Get more information

Nitric Oxide Synthesis Inhibition Promotes Renal Production of Carbon Monoxide by Rodriguez, Francisca, Lamon, Brian D, Gong, Weiying, Kemp, Rowena, Nasjletti, Alberto

“…ABSTRACT—We tested the hypothesis that the status of NO synthesis influences the renal heme-heme oxygenase system. Studies were conducted in untreated rats and…”
Get full text

Leveraging a clinical research information system to assist biospecimen data and workflow management: a hybrid approach by Nadkarni, Prakash M, Kemp, Rowena, Parikh, Chirag R

“…Large multi-center clinical studies often involve the collection and analysis of biological samples. It is necessary to ensure timely, complete and accurate…”
Get full text

Decreased Levels of Cytochrome P450 2E1–Derived Eicosanoids Sensitize Renal Arteries to Constrictor Agonists in Spontaneously Hypertensive Rats by Zhang, Fan, Deng, Huan, Kemp, Rowena, Singh, Harpreet, Gopal, Venkat Raj, Falck, John R, Laniado-Schwartzman, Michal, Nasjletti, Alberto

“…We compared renal interlobar arteries of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) in terms of cytochrome P450 (CYP) 4A and CYP2E1…”
Get full text

Effect of Androgen treatment on renal vascular CYP 4A expression, 20‐HETE synthesis and blood pressure by Singh, Harpreet, Deng, Huan, Kemp, Rowena, Wang, Jishi, Nasjletti, Alberto, Schwartzman, Michal Laniado

“…Epidemiological evidence suggests a role for sex‐dependent mechanisms in the pathophysiology of hypertension. Cytochrome P450 (CYP) 4A‐derived aracidonic acid…”
Get full text

CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin by Zhang, Fan, Kaide, Jun Ichi, Yang, LiMing, Jiang, Houli, Quan, Shuo, Kemp, Rowena, Gong, Weiying, Balazy, Michael, Abraham, Nader G, Nasjletti, Alberto

“…Pulmonary intralobar arteries express heme oxygenase (HO)-1 and -2 and release carbon monoxide (CO) during incubation in Krebs buffer. Acute hypoxia elicits…”
Get more information

Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. Commentary by ROMAN, Richard J, LOMBARD, Julian H, SINGH, Harpreet, CHENG, Jennifer, HUAN DENG, KEMP, Rowena, ISHIZUKA, Tsuneo, NASJLETTI, Alberto, LANIADO SCHWARTZMAN, Michal

Get full text

Regulation of preglomerular microvascular 20-hydroxyeicosatetraenoic acid levels by salt depletion by Carroll, M A, Kemp, R, Cheng, M K, McGiff, J C

“…20-hydroxyeicosatetraenoic acid (20-HETE) is the preeminent renal eicosanoid. The protean properties of 20-HETE - vasoactivity, mitogenicity and modulation of…”
Get more information

Urinary proteomic analysis of chronic allograft nephropathy: Renal and Urinary Proteomics by O'RIORDAN, Edmond, ORLOVA, Tatyana N, DELANEY, Veronica, GOLIGORSKY, Michael S, MENDELEV, Natalia, PATSCHAN, Daniel, KEMP, Rowena, CHANDER, Praveen N, HU, Rena, GANG HAO, GROSS, Steven S, IOZZO, Renato V

Get full text