Search Results - "Kemp, Michael G"

Pharmacological inhibition of cryptochrome and REV-ERB promotes DNA repair and cell cycle arrest in cisplatin-treated human cells by Anabtawi, Nadeen, Cvammen, William, Kemp, Michael G.

“…Nucleotide excision repair (NER) and cell cycle checkpoints impact the ability of the anti-cancer drug cisplatin to inhibit cell proliferation and induce cell…”
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Roles of UVA radiation and DNA damage responses in melanoma pathogenesis by Khan, Aiman Q., Travers, Jeffrey B., Kemp, Michael G., Menck, C.

“…The growing incidence of melanoma is a serious public health issue that merits a thorough understanding of potential causative risk factors, which includes…”
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The Impact of the Circadian Clock on Skin Physiology and Cancer Development by Lubov, Janet E, Cvammen, William, Kemp, Michael G

“…Skin cancers are growing in incidence worldwide and are primarily caused by exposures to ultraviolet (UV) wavelengths of sunlight. UV radiation induces the…”
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Evidence for the involvement of keratinocyte-derived microvesicle particles in the photosensitivity associated with xeroderma pigmentosum type A deficiency by Christian, Lea, Manjrekar, Pranali, Henkels, Karen M, Rapp, Christine M, Annamraju, Risha, Lohade, Rushabh P, Singh, Shikshita, Carpenter, M Alexandra, Khan, Saman, Kemp, Michael G, Chen, Yanfang, Sahu, Ravi P, Travers, Jeffrey B

“…Photosensitivity can be due to numerous causes. The photosensitivity associated with deficiency of xeroderma pigmentosum type A (XPA) has been previously shown…”
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Crosstalk Between Apoptosis and Autophagy: Environmental Genotoxins, Infection, and Innate Immunity by Kemp, Michael G

“…Autoimmune disorders constitute a major and growing health concern. However, the genetic and environmental factors that contribute to or exacerbate disease…”
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UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1) by Kemp, Michael G., Lindsey-Boltz, Laura A., Sancar, Aziz

“…The mechanism by which ultraviolet (UV) wavelengths of sunlight trigger or exacerbate the symptoms of the autoimmune disorder lupus erythematosus is not known…”
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Analysis of Circadian Clock Gene Expression in Human Skin Explants by Cvammen, William, Kemp, Michael G.

“…Many aspects of skin biochemistry and physiology are known to vary over the course of the 24-hour day. Traditional approaches to study circadian rhythms in the…”
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The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin by Gaddameedhi, Shobhan, Selby, Christopher P., Kemp, Michael G., Ye, Rui, Sancar, Aziz

“…Epidemiological studies of humans and experimental studies with mouse models suggest that sunburn resulting from exposure to excessive UV light and damage to…”
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Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin by Kemp, Michael G, Spandau, Dan F, Travers, Jeffrey B

“…The growing incidence of non-melanoma skin cancer (NMSC) necessitates a thorough understanding of its primary risk factors, which include exposure to…”
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Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair by Kemp, Michael G., Reardon, Joyce T., Lindsey-Boltz, Laura A., Sancar, Aziz

“…A wide range of environmental and carcinogenic agents form bulky lesions on DNA that are removed from the human genome in the form of short, ∼30-nucleotide…”
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Insulin-like Growth Factor 1 Receptor Signaling Is Required for Optimal ATR-CHK1 Kinase Signaling in Ultraviolet B (UVB)-irradiated Human Keratinocytes by Kemp, Michael G., Spandau, Dan F., Simman, Richard, Travers, Jeffrey B.

“…UVB wavelengths of light induce the formation of photoproducts in DNA that are potentially mutagenic if not properly removed by the nucleotide excision repair…”
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DNA excision repair: Where do all the dimers go? by Kemp, Michael G., Sancar, Aziz

“…Exposure of cells to UV light from the sun causes the formation of pyrimidine dimers in DNA that have the potential to lead to mutation and cancer. In humans,…”
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Nucleotide excision repair by dual incisions in plants by Canturk, Fazile, Karaman, Muhammet, Selby, Christopher P., Kemp, Michael G., Kulaksiz-Erkmen, Gulnihal, Hu, Jinchuan, Li, Wentao, Lindsey-Boltz, Laura A., Sancar, Aziz

“…Plants use light for photosynthesis and for various signaling purposes. The UV wavelengths in sunlight also introduce DNA damage in the form of cyclobutane…”
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Spironolactone and XPB: An Old Drug with a New Molecular Target by Gabbard, Ryan D, Hoopes, Robert R, Kemp, Michael G

“…Spironolactone (SP) is commonly used for the treatment of heart failure, hypertension, and complications of cirrhosis by antagonizing the mineralocorticoid…”
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Protocol for immunodot blot detection of UVB photoproducts in extracellular DNA by Carpenter, M. Alexandra, Yerrapragada, Sri, Alex, Aleena, Kemp, Michael G.

“…UV radiation induces the formation of adducts in genomic DNA within cells that are later found to be present in cell-free fractions associated with…”
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Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System by Lindsey-Boltz, Laura A., Kemp, Michael G., Reardon, Joyce T., DeRocco, Vanessa, Iyer, Ravi R., Modrich, Paul, Sancar, Aziz

“…DNA repair and DNA damage checkpoints work in concert to help maintain genomic integrity. In vivo data suggest that these two global responses to DNA damage…”
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DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair by Kemp, Michael G., Gaddameedhi, Shobhan, Choi, Jun-Hyuk, Hu, Jinchuan, Sancar, Aziz

“…Ultraviolet (UV) photoproducts are removed from genomic DNA by dual incisions in humans in the form of 24- to 32-nucleotide-long oligomers (canonical 30-mers)…”
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Creatine and Nicotinamide Prevent Oxidant-Induced Senescence in Human Fibroblasts by Mahajan, Avinash S, Arikatla, Venkata S, Thyagarajan, Anita, Zhelay, Tetyana, Sahu, Ravi P, Kemp, Michael G, Spandau, Dan F, Travers, Jeffrey B

“…Dermal fibroblasts provide structural support by producing collagen and other structural/support proteins beneath the epidermis. Fibroblasts also produce…”
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Wounding Therapies for Prevention of Photocarcinogenesis by Frommeyer, Timothy C, Rohan, Craig A, Spandau, Dan F, Kemp, Michael G, Wanner, Molly A, Tanzi, Elizabeth, Travers, Jeffrey B

“…The occurrence of non-melanoma skin cancer (NMSC) is closely linked with advanced age and ultraviolet-B (UVB) exposure. More specifically, the development of…”
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Topical Treatment of Human Skin and Cultured Keratinocytes with High-Dose Spironolactone Reduces XPB Expression and Induces Toxicity by Carpenter, M. Alexandra, Kemp, Michael G.

“…Spironolactone (SP) is used to treat a variety of disparate disease states ranging from heart failure to acne through antagonism of the mineralocorticoid and…”
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