Search Results - "Kemp, Melissa L."

Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance by Lewis, Joshua E., Kemp, Melissa L.

“…Resistance to ionizing radiation, a first-line therapy for many cancers, is a major clinical challenge. Personalized prediction of tumor radiosensitivity is…”
Get full text

Agent-based modeling of morphogenetic systems: Advantages and challenges by Glen, Chad M, Kemp, Melissa L, Voit, Eberhard O

“…The complexity of morphogenesis poses a fundamental challenge to understanding the mechanisms governing the formation of biological patterns and structures…”
Get full text

Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment by Glen, Chad M., McDevitt, Todd C., Kemp, Melissa L.

“…The initiation of heterogeneity within a population of phenotypically identical progenitors is a critical event for the onset of morphogenesis and…”
Get full text

A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses by Adimora, Nnenna J, Jones, Dean P, Kemp, Melissa L

“…Hydrogen peroxide is appreciated as a cellular signaling molecule with second-messenger properties, yet the mechanisms by which the cell protects against…”
Get more information

iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays by Fay, Meredith E., Oshinowo, Oluwamayokun, Iffrig, Elizabeth, Fibben, Kirby S., Caruso, Christina, Hansen, Scott, Musick, Jamie O., Valdez, José M., Azer, Sally S., Mannino, Robert G., Choi, Hyoann, Zhang, Dan Y., Williams, Evelyn K., Evans, Erica N., Kanne, Celeste K., Kemp, Melissa L., Sheehan, Vivien A., Carden, Marcus A., Bennett, Carolyn M., Wood, David K., Lam, Wilbur A.

“…While microscopy-based cellular assays, including microfluidics, have significantly advanced over the last several decades, there has not been concurrent…”
Get full text

Oscillatory IL-2 stimulus reveals pertinent signaling timescales of T cell responsiveness by Kippner, Linda E, Kemp, Melissa L

“…Cell response to extracellular ligand is affected not only by ligand availability, but also by pre-existing cell-to-cell variability that enables a range of…”
Get full text

Investigation of MSC potency metrics via integration of imaging modalities with lipidomic characterization by Priyadarshani, Priyanka, Van Grouw, Alexandria, Liversage, Adrian Ross, Rui, Kejie, Nikitina, Arina, Tehrani, Kayvan Forouhesh, Aggarwal, Bhavay, Stice, Steven L., Sinha, Saurabh, Kemp, Melissa L., Fernández, Facundo M., Mortensen, Luke J.

“…Mesenchymal stem/stromal cell (MSC) therapies have had limited success so far in clinical trials due in part to heterogeneity in immune-responsive phenotypes…”
Get full text

An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies by He, Luye, Kniss, Ariel, San-Miguel, Adriana, Rouse, Tel, Kemp, Melissa L, Lu, Hang

“…Cell signaling events are orchestrated by dynamic external biochemical cues. By rapidly perturbing cells with dynamic inputs and examining the output from…”
Get more information

Author Correction: Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment by Glen, Chad M., McDevitt, Todd C., Kemp, Melissa L.

“…In the original version of this Article, an incorrect DOI number was provided in the Code Availability statement regarding the deposition of the computational…”
Get full text

Perspective: The promise of multi-cellular engineered living systems by Kamm, Roger D., Bashir, Rashid, Arora, Natasha, Dar, Roy D., Gillette, Martha U., Griffith, Linda G., Kemp, Melissa L., Kinlaw, Kathy, Levin, Michael, Martin, Adam C., McDevitt, Todd C., Nerem, Robert M., Powers, Mark J., Saif, Taher A., Sharpe, James, Takayama, Shuichi, Takeuchi, Shoji, Weiss, Ron, Ye, Kaiming, Yevick, Hannah G., Zaman, Muhammad H.

“…Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D…”
Get full text

MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer by Shukla, Kirtikar, Singh, Naveen, Lewis, Joshua E, Tsang, Allen W, Boothman, David A, Kemp, Melissa L, Furdui, Cristina M

“…Head and Neck Squamous Cell Cancer (HNSCC) presents with multiple treatment challenges limiting overall survival rates and affecting patients' quality of life…”
Get full text

Trans-spliced Cas9 allows cleavage of HBB and CCR5 genes in human cells using compact expression cassettes by Fine, Eli J., Appleton, Caleb M., White, Douglas E., Brown, Matthew T., Deshmukh, Harshavardhan, Kemp, Melissa L., Bao, Gang

“…CRISPR/Cas9 systems have been used in a wide variety of biological studies; however, the large size of CRISPR/Cas9 presents challenges in packaging it within…”
Get full text

Spatial pattern dynamics of 3D stem cell loss of pluripotency via rules-based computational modeling by White, Douglas E, Kinney, Melissa A, McDevitt, Todd C, Kemp, Melissa L

“…Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into cells from all germ lineages, making them a potentially robust cell…”
Get full text

Identification of Distinct, Quantitative Pattern Classes from Emergent Tissue-Scale hiPSC Bioelectric Properties by Norfleet, Dennis Andre, Melendez, Anja J, Alting, Caroline, Kannan, Siya, Nikitina, Arina A, Caldeira Botelho, Raquel, Yang, Bo, Kemp, Melissa L

“…Bioelectric signals possess the ability to robustly control and manipulate patterning during embryogenesis and tissue-level regeneration. Endogenous local and…”
Get full text

Redox integration of signaling and metabolism in a head and neck cancer model of radiation resistance using COSMRO by Ji, Zhiwei, Moore, Jade, Devarie-Baez, Nelmi O., Lewis, Joshua, Wu, Hanzhi, Shukla, Kirtikar, Lopez, Elsa I. Silva, Vitvitsky, Victor, Key, Chia-Chi Chuang, Porosnicu, Mercedes, Kemp, Melissa L., Banerjee, Ruma, Parks, John S., Tsang, Allen W., Zhou, Xiaobo, Furdui, Cristina M.

“…Redox metabolism is increasingly investigated in cancer as driving regulator of tumor progression, response to therapies and long-term patients’ quality of…”
Get full text

Single-Cell Kinetic Modeling of β-Lapachone Metabolism in Head and Neck Squamous Cell Carcinoma by Raddatz, Andrew D, Furdui, Cristina M, Bey, Erik A, Kemp, Melissa L

“…Head and neck squamous cell carcinoma (HNSCC) cells are highly heterogeneous in their metabolism and typically experience elevated reactive oxygen species…”
Get full text

Dynamic Redox Regulation of IL-4 Signaling by Dwivedi, Gaurav, Gran, Margaret A, Bagchi, Pritha, Kemp, Melissa L

“…Quantifying the magnitude and dynamics of protein oxidation during cell signaling is technically challenging. Computational modeling provides tractable,…”
Get full text

Spatially-resolved intracellular sensing of hydrogen peroxide in living cells by Warren, Emilie A. K., Netterfield, Tatiana S., Sarkar, Saheli, Kemp, Melissa L., Payne, Christine K.

“…Understanding intracellular redox chemistry requires new tools for the site-specific visualization of intracellular oxidation. We have developed a…”
Get full text

A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity by Finn, Nnenna A, Findley, Harry W, Kemp, Melissa L

“…Although doxorubicin toxicity in cancer cells is multifactorial, the enzymatic bioactivation of the drug can significantly contribute to its cytotoxicity…”
Get full text

Gene expression signatures of extracellular matrix and growth factors during embryonic stem cell differentiation by Nair, Rekha, Ngangan, Alyssa V, Kemp, Melissa L, McDevitt, Todd C

“…Pluripotent stem cells are uniquely capable of differentiating into somatic cell derivatives of all three germ lineages, therefore holding tremendous promise…”
Get full text