Search Results - "Kemp, C J"

A Platform for Accurate Mass and Time Analyses of Mass Spectrometry Data by May, Damon, Fitzgibbon, Matt, Liu, Yan, Holzman, Ted, Eng, Jimmy, Kemp, C. J, Whiteaker, Jeff, Paulovich, Amanda, McIntosh, Martin

“…We describe an integrated suite of algorithms and software for general accurate mass and time (AMT) tagging data analysis of mass spectrometry data. The AMT…”
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Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways by Gombash, S E, Manfredsson, F P, Mandel, R J, Collier, T J, Fischer, D L, Kemp, C J, Kuhn, N M, Wohlgenant, S L, Fleming, S M, Sortwell, C E

“…Intrastriatal injection of recombinant adeno-associated viral vector serotype 2/1 (rAAV2/1) to overexpress the neurotrophic factor pleiotrophin (PTN) provides…”
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The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice by MERRITT, A. J, POTTEN, C. S, KEMP, C. J, HICKMAN, J. A, BALMAIN, A, LANE, D. P, HALL, P. A

“…Three h after whole-body irradiation (8 Gy) of C57BL x DBA/2 F1 mice, p53 protein was expressed strongly in the stem cell compartment of the small intestine…”
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p19 Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis by Ruddell, A, Kelly-Spratt, K S, Furuya, M, Parghi, S S, Kemp, C J

“…The ability of tumor cells to metastasize is increasingly viewed as an interaction between the primary tumor and host tissues. Deletion of the p19/Arf or p53…”
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p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent by KEMP, Christopher J, SHAOLI SUN, GURLEY, Kay E

“…The p53 protein rapidly accumulates in cells in response to DNA damage, which can trigger apoptosis. This pathway is hypothesized to be important for tumor…”
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Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice by BOUFFLER, S. D, KEMP, C. J, BALMAIN, A, COX, R

“…Chromosomal abnormalities have been assessed in p53-deficient mice. The in vivo frequency of spontaneous stable aberrations in bone marrow cells was elevated…”
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Distinct genetic loci control development of benign and malignant skin tumours in mice by Nagase, Hiroki, Bryson, Sheila, Cordell, Heather, Kemp, Christopher J, Fee, Frances, Balmain, Allan

“…Genetic susceptibility to chemically induced skin cancer in mice is controlled by multiple unlinked genetic loci. Mus spretus mice have dominant resistance…”
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ARF inhibits the growth and malignant progression of non-small-cell lung carcinoma by Busch, S E, Moser, R D, Gurley, K E, Kelly-Spratt, K S, Liggitt, H D, Kemp, C J

“…Non-small-cell lung carcinoma (NSCLC) is among the deadliest of human cancers. The CDKN2A locus, which houses the INK4a and ARF tumor suppressor genes, is…”
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Bax is required for increased enterocyte apoptosis after massive small bowel resection by Stern, Lawrence E., Huang, Frederick, Kemp, Christopher J., Falcone, Richard A., Erwin, Christopher R., Warner, Brad W.

“…Background: Massive small bowel resection (SBR) increases rates of both enterocyte proliferation and apoptosis. Previous studies have demonstrated increased…”
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p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer by Philipp-Staheli, J, Payne, S R, Kemp, C J

“…A major function of p27, also known as Kip1, is to bind and inhibit cyclin/cyclin-dependent kinase complexes, thereby blocking cell cycle progression. As p27…”
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Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice by Burns, P A, Kemp, C J, Gannon, J V, Lane, D P, Bremner, R, Balmain, A

“…Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model…”
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Promotion of Murine Hepatocarcinogenesis by Testosterone is Androgen Receptor-Dependent but not Cell Autonomous by Kemp, Christopher J., Leary, Cynthia N., Drinkwater, Norman R.

“…Tfm (testicular feminization) mutant mice lack functional androgen receptors. By studying liver tumor development in Tfm mice, we have shown that the greater…”
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The optical polarization of the Sun measured at a sensitivity of parts in ten million by Kemp, J. C, Henson, G. D, Steiner, C. T, Powell, E. R

“…The integrated light of the Sun would normally be found to be unpolarized, as observed in broad spectral bands with common instrumental sensitivities…”
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p53 induction, cell cycle checkpoints, and apoptosis in DNAPK- deficient scid mice by Gurley, Kay E., Kemp, Christopher J.

“…The p53 tumor suppressor protein is rapidly induced following treatment of cells with agents which cause DNA double strand breaks (dsbs) leading to cell cycle…”
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cDNA microarray analysis of adapting bowel after intestinal resection by Stern, Lawrence E., Erwin, Christopher R., Falcone, Richard A., Huang, Frederick S., Kemp, Christopher J., Williams, Jodi L., Warner, Brad W.

“…Studies of the genetic regulation of various physiologic processes have been hampered by methodologies that are limited to the analysis of individual genes…”
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DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice by GURLEY, K. E, KHOA VO, KEMP, C. J

“…The tumor-suppressing phenotype of p53 is thought to be due to its accumulation in response to DNA damage and resultant cell cycle arrest or apoptosis…”
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Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis by Kemp, Christopher J., Vo, Khoa, Gurley, Kay E.

“…Scid/scid mice have a mutation in the gene encoding the catalytic subunit of DNA-dependent protein kinase (DNAPKcs) and are defective in end joining of DNA…”
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Comparative Hepatocellular Cancer Genetics by Kemp, Christopher J.

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Intestinal adaptation occurs independent of transforming growth factor-alpha by Falcone, Richard A, Stern, Lawrence E., Kemp, Christopher J., Erwin, Christopher R., Warner, Brad W.

“…Background/Purpose: Signal transduction via the epidermal growth factor receptor (EGFR) is critical for intestinal adaptation after massive small bowel…”
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Epidermal Growth Factor Alters the bax:bcl-w Ratio Following Massive Small Bowel Resection by Stern, Lawrence E., Falcone, Richard A., Huang, Frederick, Kemp, Christopher J., Erwin, Christopher R., Warner, Brad W.

“…Background. Following massive small bowel resection (SBR), the expression of bax and bcl-w is associated with increased enterocyte apoptosis. Epidermal growth…”
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