Search Results - "Kemker, Isabell"

One-Pot Synthesis of d‑Halotryptophans by Dynamic Stereoinversion Using a Specific l‑Amino Acid Oxidase by Schnepel, Christian, Kemker, Isabell, Sewald, Norbert

“…Tryptophan (Trp) derivatives constitute important building blocks found in many natural products, peptides, and drugs. Accordingly, there is a high demand for…”
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Size‐Dependent Cellular Uptake of RGD Peptides by Kemker, Isabell, Feiner, Rebecca C., Müller, Kristian M., Sewald, Norbert

“…Monomeric RGD peptides show unspecific fluid‐phase uptake in cells, whereas multimeric RGD peptides are thought to be internalized by integrin‐mediated…”
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EGFR-Binding Peptides: From Computational Design towards Tumor-Targeting of Adeno-Associated Virus Capsids by Feiner, Rebecca C, Kemker, Isabell, Krutzke, Lea, Allmendinger, Ellen, Mandell, Daniel J, Sewald, Norbert, Kochanek, Stefan, Müller, Kristian M

“…The epidermal growth factor receptor (EGFR) plays a central role in the progression of many solid tumors. We used this validated target to analyze the de novo…”
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Self-Assembly of the Bio-Surfactant Aescin in Solution: A Small-Angle X-ray Scattering and Fluorescence Study by Dargel, Carina, Geisler, Ramsia, Hannappel, Yvonne, Kemker, Isabell, Sewald, Norbert, Hellweg, Thomas

“…This work investigates the temperature-dependent micelle formation as well as the micellar structure of the saponin aescin. The critical micelle concentration…”
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Cyclic RGD and isoDGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic (cis-β-ACPC) Scaffolds by Panzeri, Silvia, Arosio, Daniela, Gazzola, Silvia, Belvisi, Laura, Civera, Monica, Potenza, Donatella, Vasile, Francesca, Kemker, Isabell, Ertl, Thomas, Sewald, Norbert, Reiser, Oliver, Piarulli, Umberto

“…Integrin ligands containing the tripeptide sequences Arg-Gly-Asp (RGD) and iso-Asp-Gly- Arg (isoDGR) were actively investigated as inhibitors of tumor…”
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Synthesis and Biological Evaluation of RGD⁻Cryptophycin Conjugates for Targeted Drug Delivery by Borbély, Adina, Figueras, Eduard, Martins, Ana, Esposito, Simone, Auciello, Giulio, Monteagudo, Edith, Di Marco, Annalise, Summa, Vincenzo, Cordella, Paola, Perego, Raffaella, Kemker, Isabell, Frese, Marcel, Gallinari, Paola, Steinkühler, Christian, Sewald, Norbert

“…Cryptophycins are potent tubulin polymerization inhibitors with picomolar antiproliferative potency in vitro and activity against multidrug-resistant (MDR)…”
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Synthesis of substituted cycloalkene-1,1-dicarboxylates via olefin metathesis in water by Tenbrink, Katharina, Kemker, Isabell, Schatz, Jürgen, Gröger, Harald

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Linker Hydrophilicity Modulates the Anticancer Activity of RGD–Cryptophycin Conjugates by Anselmi, Michele, Borbély, Adina, Figueras, Eduard, Michalek, Carmela, Kemker, Isabell, Gentilucci, Luca, Sewald, Norbert

“…Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly…”
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Cyclization of RGD Peptides by Suzuki–Miyaura Cross-Coupling by Kemker, Isabell, Schnepel, Christian, Schröder, David C, Marion, Antoine, Sewald, Norbert

“…Halogenated l- or d-tryptophan obtained by biocatalytic halogenation was incorporated into RGD peptides together with a variety of alkyl or aryl boronic acids…”
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Phenothiazine‐Biaryl‐Containing Fluorescent RGD Peptides by Ghabraie, Elmira, Kemker, Isabell, Tonali, Nicolo, Ismail, Mohamed, Dodero, Veronica I., Sewald, Norbert

“…Cyclic RGD peptides are well‐known ligands of integrins. The integrins αVβ3 and α5β1 are involved in angiogenesis, and integrin αVβ3 is abundantly present on…”
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Tuning the Biological Activity of RGD Peptides with Halotryptophans by Kemker, Isabell, Schröder, David C, Feiner, Rebecca C, Müller, Kristian M, Marion, Antoine, Sewald, Norbert

“…An array of l- and d-halotryptophans with different substituents at the indole moiety was synthesized employing either enzymatic halogenation by halogenases or…”
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Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics by Wales, Steven M, Hammer, Katherine A, Somphol, Kittiya, Kemker, Isabell, Schröder, David C, Tague, Andrew J, Brkic, Zinka, King, Amy M, Lyras, Dena, Riley, Thomas V, Bremner, John B, Keller, Paul A, Pyne, Stephen G

“…Thirty two new binaphthyl-based, functionalized oxazole and thiazole peptidomimetics and over thirty five novel leucine-containing intermediate oxazoles and…”
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Cyclic RGD and iso DGR Integrin Ligands Containing cis -2-amino-1-cyclopentanecarboxylic ( cis -β-ACPC) Scaffolds by Panzeri, Silvia, Arosio, Daniela, Gazzola, Silvia, Belvisi, Laura, Civera, Monica, Potenza, Donatella, Vasile, Francesca, Kemker, Isabell, Ertl, Thomas, Sewald, Norbert, Reiser, Oliver, Piarulli, Umberto

“…Integrin ligands containing the tripeptide sequences Arg-Gly-Asp (RGD) and -Asp-Gly- Arg ( DGR) were actively investigated as inhibitors of tumor angiogenesis…”
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