Search Results - "Kemeny, D. M."

Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D by Tan, Kar Wai, Chong, Shu Zhen, Wong, Fiona H.S., Evrard, Maximilien, Tan, Sandra Min-Li, Keeble, Jo, Kemeny, D.M., Ng, Lai Guan, Abastado, Jean-Pierre, Angeli, Véronique

“…Lymphangiogenesis is an important physiological response to inflammatory insult, acting to limit inflammation. Macrophages, dendritic cells, and lymphocytes…”
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The role of the T follicular helper cells in allergic disease by Kemeny, DM

“…T follicular helper （Tfh） cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is…”
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Murine models of asthma by Kips, J.C, Anderson, G.P, Fredberg, J.J, Herz, U, Inman, M.D, Jordana, M, Kemeny, D.M, Lotvall, J, Pauwels, R.A, Plopper, C.G, Schmidt, D, Sterk, P.J, Van Oosterhout, A.J.M, Vargaftig, B.B, Chung, K.F

“…In vivo animal models can offer valuable information on several aspects of asthma pathogenesis and treatment. The mouse is increasingly used in these models,…”
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Attenuated Bordetella pertussis BPZE1 protects against allergic airway inflammation and contact dermatitis in mouse models by Li, R., Cheng, C., Chong, S. Z., Lim, A. R. F., Goh, Y. F., Locht, C., Kemeny, D. M., Angeli, V., Wong, W. S. F., Alonso, S.

“…Background We previously reported that prior nasal administration of highly attenuated Bordetella pertussis BPZE1 provides effective and sustained protection…”
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novel technique to explore the functions of bronchial mucosal T cells in chronic obstructive pulmonary disease: application to cytotoxicity and cytokine immunoreactivity by Lethbridge, M.W, Kemeny, D.M, Ratoff, J.C, O'Connor, B.J, Hawrylowicz, C.M, Corrigan, C.J

“…Bronchial mucosal CD8⁺ cells are implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, but there are few data on their functional…”
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BiP, a putative autoantigen in rheumatoid arthritis, stimulates IL‐10‐producing CD8‐positive T cells from normal individuals by Bodman‐Smith, M. D., Corrigall, V. M., Kemeny, D. M., Panayi, G. S.

“…Objectives. We have reported that synovial fluid T cells from patients with rheumatoid arthritis (RA) proliferate in response to the endoplasmic reticulum…”
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Inhaled endotoxin in healthy human subjects: A dose-related study on systemic effects and peripheral CD4+ and CD8+ T cells by Loh, L.C., Vyas, B., Kanabar, V., Kemeny, D.M., O’Connor, B.J.

“…Inhaled endotoxin or lipopolysaccharide (LPS) is implicated in the pathogenesis of pulmonary diseases. We investigated the inhalation effects of two different…”
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Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes by VUKMANOVIC-STEJIC, M, VYAS, B, GORAK-STOLINSKA, P, NOBLE, A, KEMENY, D. M

“…It has recently become clear that distinct subsets of CD8 T cells, analogous to their CD4 counterparts, exist in rodents and humans. To examine functional…”
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Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma by Huang, T J, MacAry, P A, Eynott, P, Moussavi, A, Daniel, K C, Askenase, P W, Kemeny, D M, Chung, K F

“…Th2 T cell immune-driven inflammation plays an important role in allergic asthma. We studied the effect of counterbalancing Th1 T cells in an asthma model in…”
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CD8 T Cells Inhibit IgE Via Dendritic Cell IL-12 Induction That Promotes Th1 T Cell Counter-Regulation by Thomas, Matthew J, Noble, Alistair, Sawicka, Ela, Askenase, Philip W, Kemeny, David M

“…Th1 and Th2 cells are counterinhibitory; their balance determines allergic sensitization. We show here that CD8 T cell subsets break these rules as both T…”
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Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy by Ruiz, R G, Kemeny, D M, Price, J F

“…The risk of infantile atopic dermatitis (AD) posed by maternal atopy and paternal atopy, respectively, were compared in the infants from a birth cohort in whom…”
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Corticosteroids restore the balance between locally produced Th1 and Th2 cytokines and immunoglobulin isotypes to normal in sarcoid lung by MILBURN, H. J., POULTER, L. W., DILMEC, A., COCHRANE, G. M., KEMENY, D. M.

“…In this study, we have investigated the balance between Th1‐ and Th2‐like activity in the lungs in sarcoidosis and have determined the effect of corticosteroid…”
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Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared with Escherichia coli by Soldatova, Lyudmila N., Crameri, Reto, Gmachl, Michael, Kemeny, David M., Schmidt, Margit, Weber, Margrit, Mueller, Ulrich R.

“…Background: Hyaluronidase (Hya) is one of several allergens in honeybee venom. Its cDNA sequence was recently described. Objective: We sought to express…”
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Contribution of CD4+ and CD8+ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens by DEARMAN, R. J., MOUSSAVI, A., KEMENY, D. M., KIMBER, I.

“…Chemical allergens of different types, those that cause in humans allergic contact dermatitis or occupational asthma, induce in mice divergent immune responses…”
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Oral allergy syndrome (OAS): symptoms of IgE-mediated hypersensitivity to foods by Amlot, P L, Kemeny, D M, Zachary, C, Parkes, P, Lessof, M H

“…Eighty highly atopic patients were selected for study because they had either atopic eczema (fifty cases) or atopic reactivity to foods, as judged by a…”
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Suppression of airway eosinophilia by killed Mycobacterium vaccae -induced allergen-specific regulatory T-cells by Zuany-Amorim, Claudia, Sawicka, Elzbieta, Manlius, Corinne, Le Moine, Alain, Brunet, Laura R, Kemeny, David M, Bowen, Gareth, Rook, Graham, Walker, Christoph

“…Allergic asthma is a chronic inflammatory disease and despite the introduction of potent and effective drugs, the prevalence has increased substantially over…”
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Novel CD4 and CD8 T‐cell subsets by Thomas, M. J., Kemeny, D. M.

“…T cells are central to the immune responses as both regulators and effectors of immune function. These functions are largely mediated by the cytokines they…”
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Cytokine production by CD4+ and CD8+ T cells in mice following primary exposure to chemical allergens: evidence for functional differentiation of T lymphocytes in vivo by Moussavi, A, Dearman, R J, Kimber, I, Kemeny, D M

“…It has been demonstrated previously that repeated exposure of mice to chemical allergens of different types results in the development of qualitatively…”
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CD8+ T cell subsets and chronic obstructive pulmonary disease by KEMENY, D. M, VYAS, B, VUKMANOVIC-STEJIC, M, THOMAS, M. J, NOBLE, A, LOH, L.-C, O'CONNOR, B. J

“…COPD is a debilitating and progressive condition in which the airways become irreversibly obstructed and the lungs progressively damaged. Unlike asthma, we…”
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Effect of CD8+ T‐cell depletion on bronchial hyper‐responsiveness and inflammation in sensitized and allergen‐exposed Brown–Norway rats by Huang, T J, MacAry, P A, Kemeny, D M, Chung, K F

“…We examined the role of CD8+ T cells in a Brown–Norway rat model of asthma, using a monoclonal antibody to deplete CD8+ T cells. Ovalbumin (OA)‐sensitized…”
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