Two new antimicrobial steroids and other constituents from the whole plant of Ludwigia abyssinica

Two new antimicrobial steroids and other constituents from the whole plant of Ludwigia abyssinica

The genus Ludwigia belongs to the Onagraceae family and it encompasses seventy-five species of aquatic plants. The chemistry of this genus is scarcely investigated, although some studies have demonstrated the potential of Ludwigia leptocarpa to produce important bioactive compounds. Herein, we descr...

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Published in:Phytochemistry letters Vol. 52; pp. 27 - 32
Main Authors: Meli, Arlette Sonkoue, Mabou, Florence Déclaire, Ngnokam, Claudia Darille Jouogo, Kembou, Alex Junior Ngoufack, Tamokou, Jean-De-Dieu, Matsuete, Germaine Takongmo, Voutquenne-Nazabadioko, Laurence, Tsopmo, Apollinaire, Ngnokam, David
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-12-2022
Elsevier
Subjects:
Analytical chemistry
Antimicrobial
Chemical Sciences
Ludwigia abyssinica
Ludwigiaformyl
Onagraceae
Organic chemistry
Steroids derivatives
Antimicrobial
Onagraceae
Ludwigia abyssinica
Ludwigiaformyl
Steroids derivatives
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Summary:The genus Ludwigia belongs to the Onagraceae family and it encompasses seventy-five species of aquatic plants. The chemistry of this genus is scarcely investigated, although some studies have demonstrated the potential of Ludwigia leptocarpa to produce important bioactive compounds. Herein, we describe the phytochemical investigation of Ludwigia abyssinica A. Rich. Two new steroids named 3β-formyloxy-5α,6α-dihydroxysitostane (Ludwigiaformyl A, 1) and 3β,6α-diformyloxy-5α-hydroxysitostane (Ludwigiaformyl B, 2), along with six known compounds, 3β-formyloxysitost-5-en (3), 5α,6β-dihydroxysitosterol (4), maslinic acid (5), oleanolic acid (6) and a mixture of two iridoids: linearin (7) and 1-epilinearin (8) were obtained from whole plant of L. abyssinica. The structures of the isolated compounds were established by extensive analysis of their spectroscopic and spectrometric data, which included HR-TOF-ESIMS, 1D NMR (1H, 13C) and 2D NMR (1H–1H COSY, HSQC, HMBC and ROESY) and by comparison with data reported in the literature. The antimicrobial activities of extracts, fractions, and new compounds (1) and (2) were evaluated using broth microdilution method against fungi and bacteria strains. The MeOH extract and the ethyl acetate fraction displayed different degrees of antibacterial and antifungal activities (MIC = 32 – 512 µg/mL; MMC = 64 – 512 µg/mL) whereas compounds 1 and 2 showed moderate antimicrobial activities against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Shigella flexneri and Cryptococcus neoformans (MIC = 8 – 32 µg/mL; MMC = 8 – 64 µg/mL). [Display omitted] •Two new steroid derivatives trivially named Ludwigiaformyl A and B, were isolated from Ludwigia abyssinica.•Their structures were characterized by extensive 2D NMR studies.•Six known compounds were also isolated from this plant.•Antimicrobial activities were evaluated.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2022.09.002