Search Results - "Kemble, David J."

FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs by Kemble, David J., McCullough, Laura L., Whitby, Frank G., Formosa, Tim, Hill, Christopher P.

“…FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in…”
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Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation by Kemble, David J, Sun, Gongqin

“…Accumulating evidence suggests that protein tyrosine phosphorylation-based signaling pathways are under the regulation of reactive oxygen species. Although…”
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Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT by Kemble, David J., Whitby, Frank G., Robinson, Howard, McCullough, Laura L., Formosa, Tim, Hill, Christopher P.

“…The histone chaperone FACT is an essential and abundant heterodimer found in all eukaryotes. Here we report a crystal structure of the middle domain of the…”
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To C or not to C: Direct and indirect redox regulation of Src protein tyrosine kinase by Sun, Gongqin, Kemble, David J.

“…Src protein tyrosine kinase is a master regulator of cell proliferation by modulating cell metabolism, division, survival and migration, thus the mechanisms…”
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Not the usual suspect: Polymeric IgA paraprotein causes false positive results in kinetic interaction of microparticles in solution (KIMS) immunoassays by Kemble, David J., Lamothe, Simon, Uhl, Lynne

“…Immunoassays are commonly used by the clinical laboratory, but paraproteins can occasionally produce erroneous results. In this study, we investigated the…”
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Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation by Chen, Lingfeng, Marsiglia, William M., Chen, Huaibin, Katigbak, Joseph, Erdjument-Bromage, Hediye, Kemble, David J., Fu, Lili, Ma, Jinghong, Sun, Gongqin, Zhang, Yingkai, Liang, Guang, Neubert, Thomas A., Li, Xiaokun, Traaseth, Nathaniel J., Mohammadi, Moosa

“…A long-standing mystery shrouds the mechanism by which catalytically repressed receptor tyrosine kinase domains accomplish transphosphorylation of activation…”
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Docking-based Substrate Recognition by the Catalytic Domain of a Protein Tyrosine Kinase, C-terminal Src Kinase (Csk) by Lee, Sungsoo, Ayrapetov, Marina K., Kemble, David J., Parang, Keykavous, Sun, Gongqin

“…Protein tyrosine kinases are key enzymes of mammalian signal transduction. Substrate specificity is a fundamental property that determines the specificity and…”
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Approaches to drug monitoring: partnering with the clinical laboratory by Herskovits, A. Zara, Kemble, David J., Uhl, Lynne

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Error! Hemoglobin A1c Outside of Range by Rodrigue, Bentley B, Lamothe, Simon, Kemble, David J

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A Single-Column Gas Chromatography Method for Quantifying Toxic Alcohols by Kemble, David J, Cervinski, Mark A

“…Rapid identification and quantification of toxic alcohols and ethylene glycol is imperative for appropriate treatment. Clinical laboratories frequently rely on…”
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Analytical and Clinical Validation of Two Commercially Available Immunoassays Used in the Detection of TSHR Antibodies by Kemble, David J, Jackson, Tara, Morrison, Mike, Cervinski, Mark A, Nerenz, Robert D

“…Graves disease is caused by autoantibodies that target the thyroid-stimulating hormone receptor (TSHR). Anti-TSHR autoantibody measurement is routinely…”
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Bacterial Expression and Characterization of Catalytic Loop Mutants of Src Protein Tyrosine Kinase by Kemble, David J., Wang, Yue-Hao, Sun, Gongqin

“…Protein tyrosine kinase Src is a key enzyme in mammalian signal transduction and an important target for anticancer drug discovery. Although recombinant…”
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The Urine that Would Not Freeze by Kemble, David J, Brunelle, Abigail A, Boulanger, James A, Cervinski, Mark A, Nerenz, Robert D

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A biochemical study on the regulation of the Src and FGFR family of protein tyrosine kinases by Kemble, David J

“…The Src and FGFR family of protein tyrosine kinases (PTKs) are key mammalian enzymes in signal transduction. Regulating their enzymatic activity is imperative…”
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A biochemical study on the regulation of the Src and FGFR family of protein tyrosine kinases by Kemble, David J

“…The Src and FGFR family of protein tyrosine kinases (PTKs) are key mammalian enzymes in signal transduction. Regulating their enzymatic activity is imperative…”
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