Search Results - "Kema, I. P."

Plasma levels of free metanephrines and 3-methoxytyramine indicate a higher number of biochemically active HNPGL than 24-h urinary excretion rates of catecholamines and metabolites by van Duinen, N, Corssmit, E P M, de Jong, W H A, Brookman, D, Kema, I P, Romijn, J A

“…ContextA substantial number of patients with head and neck paragangliomas (HNPGLs) have biochemically active tumors, evidenced by increased urinary excretion…”
Get full text

Increased Urinary Excretion of 3-Methoxytyramine in Patients with Head and Neck Paragangliomas by van Duinen, N, Steenvoorden, D, Kema, I. P, Jansen, J. C, Vriends, A. H. J. T, Bayley, J. P, Smit, J. W. A, Romijn, J. A, Corssmit, E. P. M

“…Context: Patients with head-and-neck paragangliomas (HNPGL) are regularly screened for catecholamine excess. The clinical relevance of increased urinary…”
Get full text

Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA by JABBI, M, KORF, J, KEMA, I. P, HARTMAN, C, VAN DER POMPE, G, MINDERAA, R. B, ORMEL, J, DEN BOER, J. A

“…Highly prevalent stress-related disorders such as major depression (MD) are characterised by a dysregulation of the neuroendocrine system. Although…”
Get full text

The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer’s Disease by Sorgdrager, FJH, van Der Ley, CP, van Faassen, M, Calus, E, Nollen, EA, Kema, IP, van Dam, D, De Deyn, PP

“…Alzheimer’s disease (AD) is associated with progressive endogenous neurotoxicity and hampered inflammatory regulation. The kynurenine (Kyn) pathway, which is…”
Get full text

Deficiencies in fat‐soluble vitamins in long‐term users of somatostatin analogue by Fiebrich, H.‐B., Van Den Berg, G., Kema, I. P., Links, T. P., Kleibeuker, J. H., Van Beek, A. P., Walenkamp, A. M. E., Sluiter, W. J., De Vries, E. G. E.

“…Aliment Pharmacol Ther 2010; 32: 1398–1404 Summary Background  Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and…”
Get full text

Automated mass spectrometric analysis of urinary free catecholamines using on-line solid phase extraction by de Jong, Wilhelmina H.A., de Vries, Elisabeth G.E., Wolffenbuttel, Bruce H.R., Kema, I.P.

“…Analysis of catecholamines (epinephrine, norepinephrine and dopamine) in plasma and urine is used for diagnosis and treatment of catecholamine-producing…”
Get full text

Ion chromatography for the precise analysis of chloride and sodium in sweat for the diagnosis of cystic fibrosis by Doorn, J, Storteboom, T T R, Mulder, A M, de Jong, W H A, Rottier, B L, Kema, I P

“…Measurement of chloride in sweat is an essential part of the diagnostic algorithm for cystic fibrosis. The lack in sensitivity and reproducibility of current…”
Get more information

Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes by BLOKS, V. W, BAKKER-VAN WAARDE, W. M, VERKADE, H. J, KEMA, I. P, WOLTERS, H, VINK, E, GROEN, A. K, KUIPERS, F

“…Type I diabetes is associated with altered hepatic bile formation and increased intestinal cholesterol absorption. The aim of this study was to evaluate…”
Get full text

Resumption of ovulation in anovulatory women with PCOS and obesity is associated with reduction of 11β-hydroxyandrostenedione concentrations by Wang, Z, Van Faassen, M, Groen, H, Cantineau, A E P, Van Oers, A, Van der Veen, A, Hawley, J M, Keevil, B G, Kema, I P, Hoek, A

“…Is resumption of ovulation after a 6-month lifestyle intervention in women with PCOS and obesity associated with differential changes in endocrine and…”
Get full text

LC-MS/MS in clinical chemistry: Did it live up to its promise?: Consideration from the Dutch EQAS organisation by Lentjes, E G W M, Bui, H N, Ruhaak, L R, Kema, I P, Coene, K L M, van den Ouweland, J M W

“…Over the past decade the use of LC-MS/MS has increased significantly in the hospital laboratories. Clinical laboratories have switched from immunoassays to…”
Get full text

Prenatal and pubertal testosterone affect brain lateralization by Beking, T., Geuze, R.H., van Faassen, M., Kema, I.P., Kreukels, B.P.C., Groothuis, T.G.G.

“…[Display omitted] •This longitudinal study uses direct measurements of testosterone and lateralization.•Both prenatal and pubertal testosterone relate to brain…”
Get full text

A rare cause of congenital adrenal hyperplasia: Antley-Bixler syndrome due to POR deficiency by HERKERT, J. C, BLAAUWWIEKEL, E. E, HOEK, A, VEENSTRA-KNOL, H. E, KEMA, I. P, ARLT, W, KERSTENS, M. N

“…Cytochrome P450 oxidoreductase (POR) deficiency is a recently discovered new variant of congenital adrenal hyperplasia. Distinctive features of POR deficiency…”
Get full text

The association between the hypothalamic pituitary adrenal axis and tryptophan metabolism in persons with recurrent major depressive disorder and healthy controls by Sorgdrager, F.J.H., Doornbos, B., Penninx, B.W.J.H., de Jonge, P., Kema, I.P.

“…Persistent changes in serotonergic and hypothalamic pituitary adrenal (HPA) axis functioning are implicated in recurrent types of major depressive disorder…”
Get full text

Diagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors by Kerkhofs, T. M. A., Kerstens, M. N., Kema, I. P., Willems, T. P., Haak, H. R.

“…Radiological examination may unexpectedly reveal an adrenal mass. Current algorithms for differentiating between benign and malignant lesions mainly rely on…”
Get full text

Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment by Kuipers, S.D., Trentani, A., Westenbroek, C., Bramham, C.R., Korf, J., Kema, I.P., Ter Horst, G.J., Den Boer, J.A.

“…Affective disorders are common psychiatric illnesses characterized by marked gender-related prevalence. Recent evidence links chronic stress and dysregulation…”
Get full text

Low essential fatty acid and B-vitamin status in a subgroup of patients with schizophrenia and its response to dietary supplementation by Kemperman, R.F.J., Veurink, M., van der Wal, T., Knegtering, H., Bruggeman, R., Fokkema, M.R., Kema, I.P., Korf, J., Muskiet, F.A.J.

“…We assessed essential fatty acid (EFA) and B-vitamin status, together with their determinants, in 61 patients with schizophrenia and established whether those…”
Get full text

The increasing importance of LNAA supplementation in phenylketonuria at higher plasma phenylalanine concentrations by van Vliet, D., van der Goot, E., van Ginkel, W.G., van Faassen, H.J.R., de Blaauw, P., Kema, I.P., Heiner-Fokkema, M.R., van der Zee, E.A., van Spronsen, F.J.

“…Large neutral amino acid (LNAA) treatment has been suggested as alternative to the burdensome severe phenylalanine-restricted diet. While its working…”
Get full text

Determinants of HbA1c in nondiabetic Dutch adults: genetic loci and clinical and lifestyle parameters, and their interactions in the lifelines cohort study by Jansen, H., Stolk, R. P., Nolte, I. M., Kema, I. P., Wolffenbuttel, B. H. R., Snieder, H.

“…Objectives Glycated haemoglobin (HbA1c) is associated with cardiovascular disease risk in individuals without diabetes, and its use has been recommended for…”
Get full text

Pharmacological screening identifies SHK242 and SHK277 as novel arginase inhibitors with efficacy against allergen-induced airway narrowing in vitro and in vivo by Van den Berg, Mariska P M, Kurhade, Santosh H, Maarsingh, Harm, Erceg, Stefanie, Hulsbeek, Imke R, Boekema, Pieter H, Kistemaker, Loes E M, van Faassen, Martijn, Kema, Ido P, Elsinga, Philip H, Dömling, Alex S S, Meurs, Herman, Gosens, Reinoud

“…Arginase is a potential target for asthma treatment. However, currently there are no arginase inhibitors available for clinical use. Here a novel class of…”
Get full text

Discriminating Capacity of Indole Markers in the Diagnosis of Carcinoid Tumors by Meijer, Wim G, Kema, Ido P, Volmer, Marcel, Willemse, Pax H.B, de Vries, Elisabeth G.E

“…We evaluated the discriminating capacity of the indole markers urinary 5-hydroxyindoleacetic acid (5-HIAA), urinary serotonin, and platelet serotonin in the…”
Get full text