Search Results - "Kelso, Michael J"

Nitric oxide: a key mediator of biofilm dispersal with applications in infectious diseases by Barraud, Nicolas, Kelso, Michael J, Rice, Scott A, Kjelleberg, Staffan

“…Studies of the biofilm life cycle can identify novel targets and strategies for improving biofilm control measures. Of particular interest are dispersal…”
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A comparison of patient matched meibum and tear lipidomes by Brown, Simon H J, Kunnen, Carolina M E, Duchoslav, Eva, Dolla, Naveen K, Kelso, Michael J, Papas, Eric B, Lazon de la Jara, Percy, Willcox, Mark D P, Blanksby, Stephen J, Mitchell, Todd W

“…To quantify the molecular lipid composition of patient-matched tear and meibum samples and compare tear and meibum lipid molecular profiles. Lipids were…”
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Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors by Buckley, Benjamin J, Kumar, Ashna, Aboelela, Ashraf, Bujaroski, Richard S, Li, Xiuju, Majed, Hiwa, Fliegel, Larry, Ranson, Marie, Kelso, Michael J

“…The K -sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent models. These effects arise from the inhibition of two distinct…”
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Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids by Hancock, Sarah E., Ailuri, Ramesh, Marshall, David L., Brown, SimonH.J., Saville, Jennifer T., Narreddula, Venkateswara R., Boase, Nathan R., Poad, BerwyckL.J., Trevitt, Adam J., Willcox, MarkD.P., Kelso, Michael J., Mitchell, Todd W., Blanksby, Stephen J.

“…The (O-acyl)-ω-hydroxy FAs (OAHFAs) comprise an unusual lipid subclass present in the skin, vernix caseosa, and meibomian gland secretions. Although they are…”
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Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry by Marshall, David L., Saville, Jennifer T., Maccarone, Alan T., Ailuri, Ramesh, Kelso, Michael J., Mitchell, Todd W., Blanksby, Stephen J.

“…Rationale (O‐acyl)‐hydroxy fatty acids (OAHFAs) are a recently discovered class of endogenous lipids, generating significant interest for their correlation…”
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Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs by Vu, Kiem, Buckley, Benjamin J, Bujaroski, Richard S, Blumwald, Eduardo, Kelso, Michael J, Gelli, Angie

“…Fungal infections have become an increasing threat as a result of growing numbers of susceptible hosts and diminishing effectiveness of antifungal drugs due to…”
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Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin—resistant Staphylococcus aureus by Johnston, Tatiana, Van Tyne, Daria, Chen, Roy F., Fawzi, Nicolas L., Kwon, Bumsup, Kelso, Michael J., Gilmore, Michael S., Mylonakis, Eleftherios

“…The emergence of Staphylococcus aureus strains resistant to ‘last resort’ antibiotics compels the development of new antimicrobials against this important…”
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6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist by Cuthbertson, Peter, Elhage, Amal, Al-Rifai, Dena, Sophocleous, Reece A., Turner, Ross J., Aboelela, Ashraf, Majed, Hiwa, Bujaroski, Richard S., Jalilian, Iman, Kelso, Michael J., Watson, Debbie, Buckley, Benjamin J., Sluyter, Ronald

“…P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine…”
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Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach by Khader, Rajamohammed, Tharmalingam, Nagendran, Mishra, Biswajit, Felix, LewisOscar, Ausubel, Frederick M., Kelso, Michael J., Mylonakis, Eleftherios

“…There is a significant need to combat the growing challenge of antibacterial drug resistance. We have previously developed a whole-animal dual-screening…”
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An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis by Hards, Kiel, Cheung, Chen-Yi, Waller, Natalie, Adolph, Cara, Keighley, Laura, Tee, Zhi Shean, Harold, Liam K., Menorca, Ayana, Bujaroski, Richard S., Buckley, Benjamin J., Tyndall, Joel D. A., McNeil, Matthew B., Rhee, Kyu Y., Opel-Reading, Helen K., Krause, Kurt, Preiss, Laura, Langer, Julian D., Meier, Thomas, Hasenoehrl, Erik J., Berney, Michael, Kelso, Michael J., Cook, Gregory M.

“…Increasing antimicrobial resistance compels the search for next-generation inhibitors with differing or multiple molecular targets. In this regard, energy…”
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A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives by Gornall, Karina C, Samosorn, Siritron, Tanwirat, Bongkot, Suksamrarn, Apichart, Bremner, John B, Kelso, Michael J, Beck, Jennifer L

“…ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and…”
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Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA) by Matthews, Hayden, Ranson, Marie, Tyndall, Joel D.A., Kelso, Michael J.

“…A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K i = 7 μM),…”
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Anti‐tumour/metastasis effects of the potassium‐sparing diuretic amiloride: An orally active anti‐cancer drug waiting for its call‐of‐duty? by Matthews, Hayden, Ranson, Marie, Kelso, Michael J.

“…Amiloride.HCl is clinically used as an oral potassium‐sparing diuretic, but multiple studies in biochemical, cellular and animal models have shown that the…”
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Berberine-INF55 (5-Nitro-2-Phenylindole) Hybrid Antimicrobials: Effects of Varying the Relative Orientation of the Berberine and INF55 Components by TOMKIEWICZ, Danuta, CASADEI, Gabriele, LARKINS-FORD, Jonah, MOY, Terence I, GARNER, James, BREMNER, John B, AUSUBEL, Frederick M, LEWIS, Kim, KELSO, Michael J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Ion Transport and Inhibitor Binding by Human NHE1: Insights from Molecular Dynamics Simulations and Free Energy Calculations by El Salamouni, Nehad S., Buckley, Benjamin J., Lee, Richmond, Ranson, Marie, Kelso, Michael J., Yu, Haibo

“…The human Na+/H+ exchanger (NHE1) plays a crucial role in maintaining intracellular pH by regulating the electroneutral exchange of a single intracellular H+…”
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Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA) by S El Salamouni, Nehad, Buckley, Benjamin J, Jiang, Longguang, Huang, Mingdong, Ranson, Marie, Kelso, Michael J, Yu, Haibo

“…The urokinase plasminogen activator (uPA) plays a critical role in tumor cell invasion and migration and is a promising antimetastasis target. 6-Substituted…”
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6‑Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer by Buckley, Benjamin J, Aboelela, Ashraf, Minaei, Elahe, Jiang, Longguang X, Xu, Zhihong, Ali, Umar, Fildes, Karen, Cheung, Chen-Yi, Cook, Simon M, Johnson, Darren C, Bachovchin, Daniel A, Cook, Gregory M, Apte, Minoti, Huang, Mingdong, Ranson, Marie, Kelso, Michael J

“…Metastasis is the cause of death in the majority (∼90%) of malignant cancers. The oral potassium-sparing diuretic amiloride and its 5-substituted derivative…”
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Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids by Narreddula, Venkateswara R, Boase, Nathan R, Ailuri, Ramesh, Marshall, David L, Poad, Berwyck L.J, Kelso, Michael J, Trevitt, Adam J, Mitchell, Todd W, Blanksby, Stephen J

“…Fatty acids are a structurally diverse category of lipids with a myriad of biochemical functions, which includes their role as building blocks of more complex…”
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Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa by Soren, Odel, Rineh, Ardeshir, Silva, Diogo G, Cai, Yuming, Howlin, Robert P, Allan, Raymond N, Feelisch, Martin, Davies, Jane C, Connett, Gary J, Faust, Saul N, Kelso, Michael J, Webb, Jeremy S

“…Abstract Objectives The cephalosporin nitric oxide (NO)-donor prodrug DEA-C3D (‘DiEthylAmin-Cephalosporin-3′-Diazeniumdiolate’) has been shown to initiate the…”
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Cephalosporin-3′-diazeniumdiolates: Targeted NO-Donor Prodrugs for Dispersing Bacterial Biofilms by Barraud, Nicolas, Kardak, Bharat G., Yepuri, Nageshwar R., Howlin, Robert P., Webb, Jeremy S., Faust, Saul N., Kjelleberg, Staffan, Rice, Scott A., Kelso, Michael J.

“…Just say NO to biofilms: NO‐donors are used to disperse a bacterial biofilm so that co‐administered antibiotics will kill the more susceptible unattached…”
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