Search Results - "Kelso, E J"

Activation of immune and inflammatory systems in chronic heart failure: novel therapeutic approaches by Gong, K Z, Song, G, Spiers, J P, Kelso, E J, Zhang, Z G

“…Despite extensive research and novel treatments, chronic heart failure (CHF) remains a cause of high morbidity and mortality. Mounting evidence suggested that…”
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Endothelin(A) receptor subtype mediates endothelin-induced contractility in left ventricular cardiomyocytes isolated from rabbit myocardium by Kelso, E J, McDermott, B J, Silke, B, Spiers, J P

“…Endothelin (ET)-1 is a potent positive inotropic agent, the effects of which are mediated by increases in cytosolic Ca(2+) in the myocardium. The object of…”
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Inotropic response to endothelin‐1, isoprenaline and calcium in cardiomyocytes isolated from endotoxin treated rats: effects of ethyl‐isothiourea and dexamethasone by Spiers, J P, Kelso, E J, Allen, J D, Silke, B, McDermott, B J

“…The contractile effects of endothelin‐1, isoprenaline and extracellular calcium were assessed on ventricular cardiomyocytes isolated from…”
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Endothelin‐1 mediated inhibition of the acetylcholine‐activated potassium current from rabbit isolated atrial cardiomyocytes by Spiers, J. Paul, Kelso, Elizabeth J., McDermott, Barbara J., Scholfield, C. Norman, Silke, Bernard

“…1 Endothelin‐1 is a 21 amino acid peptide with potent inotropic and chronotropic actions in the heart. Relatively little is known about the underlying…”
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Cardiotonic actions of selective phosphodiesterase inhibitors in rat isolated ventricular cardiomyocytes by Kelso, Elizabeth J., McDermott, Barbara J., Silke, Bernard

“…1 The contractile effects of the novel cardiotonic agent HN‐10200 (2‐[3‐methoxy‐5‐methylsulphinyl‐2‐thienyl]‐1H‐imidazo‐[4,5‐c]‐pyridine hydrochloride), were…”
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Involvement of Endothelin (ET)A and ETB Receptors in the Hypertrophic Effects of ET-1 in Rabbit Ventricular Cardiomyocytes by Mullan, Deirdre M, Bell, David, Kelso, Elizabeth J, McDermott, Barbara J

“…The question was addressed whether endothelin-1 (ET-1) exerts hypertrophic effects in cardiomyocytes isolated from ventricles of adult rabbits and maintained…”
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Stimulation of L-type Ca2+ current by the endothelin receptor A-selective antagonist, BQ-123, in ventricular cardiomyocytes isolated from rabbit myocardium by KELSO, E. J, SPIERS, J. P, MCDERMOTT, B. J, SCHOLFIELD, C. N, SILKE, B

“…BQ-123 is extensively used as an antagonist at endothelin (ET) receptors, having selectivity at the ET(A) receptor subtype. In this study, the effects of…”
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Actions of the novel vasodilator, flosequinan, in isolated ventricular cardiomyocytes by Kelso, E J, McDermott, B J, Silke, B

“…Although the potent vasodilating effect of flosequinan is well characterised, the positive inotropic action reported is more varied and less well understood…”
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Differential effects of phosphodiesterase inhibitors on accumulation of cyclic AMP in isolated ventricular cardiomyocytes by Kelso, Elizabeth J., McDermott, Barbara J., Silke, Bernard

“…The intracellular actions of phosphodiesterase (PDE) inhibitors on the accumulation of cyclic nucleotides were studied in isolated ventricular cardiomyocytes…”
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Economic evaluation of the use of nadroparin in the treatment of deep-vein thrombosis in Switzerland by Lloyd, A C, Aitken, J A, Hoffmeyer, U K, Kelso, E J, Wakerly, E C, Barber, N D

“…To compare the cost implications, from the payer's perspective, of the use of nadroparin instead of unfractionated heparin in the initial treatment of…”
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Positive and Negative Contractile Effects of Somatostatin-14 on Rat Ventricular Cardiomyocytes by Murray, Fiona, Bell, David, Kelso, Elizabeth J, Millar, B Cherie, McDermott, Barbara J

“…Somatostatin-14 elicits negative inotropic and chronotropic actions in atrial myocardium. Less is known about the effects of somatostatin-14 in ventricular…”
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Myocardial Expression of the Endothelin System in Endotoxin- Treated Rats by Spiers, James Paul, Dorman, Alastair, Allen, John Desmond, Kelso, Elizabeth Jane, Silke, Bernard, McDermott, Barbara Jean

“…Although circulating plasma levels of endothelin (ET)-1 are elevated in endotoxemia, little is known about the myocardial expression of the ET system in…”
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Receptor-mediated effects of endothelin on the L-type Ca++ current in ventricular cardiomyocytes by Kelso, E J, Spiers, J P, McDermott, B J, Scholfield, C N, Silke, B

“…The purpose of this study was to establish whether specific receptor subtypes are responsible for mediating the effects of endothelin-1 (ET-1) and endothelin-3…”
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Characterisation of a Cellular Model of Cardiomyopathy, in the Rabbit, Produced by Chronic Administration of the Anthracycline, Epirubicin by Kelso, Elizabeth J., Geraghty, Robert F., McDermott, Barbara J., Cameron, C.H.S., Nicholls, D.Paul, Silke, Bernard

“…The objective of this study was to assess the structural, mechanical and electrophysiological changes associated with chronic administration of epirubicin…”
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Economic evaluation of the use of nadroparin calcium in the prophylaxis of deep vein thrombosis and pulmonary embolism in surgical patients in Italy by Lloyd, A, Aitken, J A, Hoffmeyer, U K, Kelso, E J, Wakerly, E C, Barber, N D

“…The objective of this study was to compare the costs, from the perspective of the payer, of using nadroparin calcium, a low-molecular-weight heparin, instead…”
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Mechanical effects of ET-1 in cardiomyocytes isolated from normal and heart-failed rabbits by Kelso, E J, Geraghty, R F, McDermott, B J, Trimble, E R, Nicholls, D P, Silke, B

“…Endothelin (ET-1) is found at elevated concentrations in the plasma of patients with heart failure and in animal models of cardiomyopathy. The peptide is a…”
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OC5 HYPERTENSIVE RETINOPATHY IN A RAT MODEL: MODULATION BY AN ENDOTHELIN-RECEPTOR ANTAGONIST by Gooyer, T. E., Lee, G. R., McDonald, L., McDonald, D., Kelso, E. J., McDermott, B. J., Stitt, A. W.

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Use of A-192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy by Cullen, J P, Bell, D, Kelso, E J, McDermott, B J

“…Increased plasma levels of endothelin-1 correlate with the severity of left ventricular hypertrophy in vivo. The aim of the study was to determine the relative…”
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Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension : effects of endothelin receptor blockade by SPIERS, James P, KELSO, Elizabeth J, SIAH, Wei F, EDGE, Gillian, GUOJIE SONG, MCDERMOTT, Barbara J, HENNESSY, Martina

“…To determine the effects of age and dual endothelin (ET)A/ETB receptor antagonism (bosentan) on aortic matrix metalloproteinase (MMP) abundance and tissue…”
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Inhibition of the acetylcholine-activated potassium current by endothelin-1 in atrial cardiomyocytes by Spiers, J. P., Kelso, E. J., McDermott, B J, Scholfield, N, Silke, B.

“…Endothelin-1 (ET-1), is a 21 amino-acid peptide with potent inotropic and chronotropic actions in the heart. Relatively little is known about the underlying…”
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