Search Results - "Kelsic, Eric D."

High-order species interactions shape ecosystem diversity by Bairey, Eyal, Kelsic, Eric D., Kishony, Roy

“…Classical theory shows that large communities are destabilized by random interactions among species pairs, creating an upper bound on ecosystem diversity…”
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Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design by Ogden, Pierce J, Kelsic, Eric D, Sinai, Sam, Church, George M

“…Adeno-associated virus (AAV) capsids can deliver transformative gene therapies, but our understanding of AAV biology remains incomplete. We generated the…”
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Counteraction of antibiotic production and degradation stabilizes microbial communities by Kelsic, Eric D., Zhao, Jeffrey, Vetsigian, Kalin, Kishony, Roy

“…Mathematical modelling and simulations reveal that including antibiotic degraders in ecological models of microbial species interaction allows the system to…”
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Spatiotemporal microbial evolution on antibiotic landscapes by Baym, Michael, Lieberman, Tami D., Kelsic, Eric D., Chait, Remy, Gross, Rotem, Yelin, Idan, Kishony, Roy

“…A key aspect of bacterial survival is the ability to evolve while migrating across spatially varying environmental challenges. Laboratory experiments, however,…”
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Deep diversification of an AAV capsid protein by machine learning by Bryant, Drew H., Bashir, Ali, Sinai, Sam, Jain, Nina K., Ogden, Pierce J., Riley, Patrick F., Church, George M., Colwell, Lucy J., Kelsic, Eric D.

“…Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of…”
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Comparing Community Structure to Characteristics in Online Collegiate Social Networks by Traud, Amanda L., Kelsic, Eric D., Mucha, Peter J., Porter, Mason A.

“…We study the structure of social networks of students by examining the graphs of Facebook "friendships" at five U.S. universities at a single point in time. We…”
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High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast by Guo, Xiaoge, Chavez, Alejandro, Tung, Angela, Chan, Yingleong, Kaas, Christian, Yin, Yi, Cecchi, Ryan, Garnier, Santiago Lopez, Kelsic, Eric D, Schubert, Max, DiCarlo, James E, Collins, James J, Church, George M

“…An optimized method to introduce precise modifications into the yeast genome enables high-throughput characterization of the phenotypic effect of mutations…”
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Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor by Russ, Dor, Glaser, Fabian, Shaer Tamar, Einat, Yelin, Idan, Baym, Michael, Kelsic, Eric D., Zampaloni, Claudia, Haldimann, Andreas, Kishony, Roy

“…Beta-lactamase inhibitors are increasingly used to counteract antibiotic resistance mediated by beta-lactamase enzymes. These inhibitors compete with the…”
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Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning by Wec, Anna Z, Lin, Kathy S, Kwasnieski, Jamie C, Sinai, Sam, Gerold, Jeff, Kelsic, Eric D

“…A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and…”
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A primer on model-guided exploration of fitness landscapes for biological sequence design by Sinai, Sam, Kelsic, Eric D

“…Machine learning methods are increasingly employed to address challenges faced by biologists. One area that will greatly benefit from this cross-pollination is…”
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AdaLead: A simple and robust adaptive greedy search algorithm for sequence design by Sinai, Sam, Wang, Richard, Whatley, Alexander, Slocum, Stewart, Locane, Elina, Kelsic, Eric D

“…Efficient design of biological sequences will have a great impact across many industrial and healthcare domains. However, discovering improved sequences…”
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Comparing Community Structure to Characteristics in Online Collegiate Social Networks by Traud, Amanda L, Kelsic, Eric D, Mucha, Peter J, Porter, Mason A

“…SIAM Review 53, 526-543 (2011) We study the structure of social networks of students by examining the graphs of Facebook "friendships" at five American…”
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