Search Results - "Kelm, Nathaniel D"

Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains by Kelm, Nathaniel D., West, Kathryn L., Carson, Robert P., Gochberg, Daniel F., Ess, Kevin C., Does, Mark D.

“…Diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and DKI-derived white matter tract integrity metrics (WMTI) were experimentally evaluated ex…”
Get full text

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100 by BYUN, Nellie E, GRANNAN, Michael, MELANCON, Bruce J, TARR, James C, BROGAN, John T, AVISON, Malcolm J, DEUTCH, Ariel Y, WESS, Jürgen, WOOD, Michael R, LINDSLEY, Craig W, GORE, John C, CONN, P. Jeffrey, BUBSER, Michael, JONES, Carrie K, BARRY, Robert L, THOMPSON, Analisa, ROSANELLI, John, GOWRISHANKAR, Raajaram, KELM, Nathaniel D, DAMON, Stephen, BRIDGESL, Thomas M

“…Accumulating evidence suggests that selective M4 muscarinic acetylcholine receptor (mAChR) activators may offer a novel strategy for the treatment of…”
Get full text

Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination by Grier, Mark D, West, Kathryn L, Kelm, Nathaniel D, Fu, Cary, Does, Mark D, Parker, Brittany, McBrier, Eleanor, Lagrange, Andre H, Ess, Kevin C, Carson, Robert P

“…Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many…”
Get full text

Multi-compartment microscopic diffusion imaging by Kaden, Enrico, Kelm, Nathaniel D., Carson, Robert P., Does, Mark D., Alexander, Daniel C.

“…This paper introduces a multi-compartment model for microscopic diffusion anisotropy imaging. The aim is to estimate microscopic features specific to the…”
Get full text

Hypomyelination following deletion of Tsc2 in oligodendrocyte precursors by Carson, Robert P., Kelm, Nathaniel D., West, Kathryn L., Does, Mark D., Fu, Cary, Weaver, Grace, McBrier, Eleanor, Parker, Brittany, Grier, Mark D., Ess, Kevin C.

“…Objective While abnormalities in myelin in tuberous sclerosis complex (TSC) have been known for some time, recent imaging‐based data suggest myelin…”
Get full text

Quantitative analysis of mouse corpus callosum from electron microscopy images by West, Kathryn L., Kelm, Nathaniel D., Carson, Robert P., Does, Mark D.

“…This article provides morphometric analysis of 72 electron microscopy images from control (n=4) and hypomyelinated (n=2) mouse corpus callosum. Measures of…”
Get full text

Myelin volume fraction imaging with MRI by West, Kathryn L., Kelm, Nathaniel D., Carson, Robert P., Gochberg, Daniel F., Ess, Kevin C., Does, Mark D.

“…MRI is a valuable tool to assess myelin during development and demyelinating disease processes. While multiexponential T2 and quantitative magnetization…”
Get full text

A novel technique using hydrophilic polymers to promote axonal fusion by Bamba, Ravinder, Riley, D, Kelm, Nathaniel, Does, Mark, Dortch, Richard, Thayer, Wesley

“…The management of traumatic peripheral nerve injury remains a considerable concern for clinicians.With minimal innovations in surgical technique and a limited…”
Get full text

A revised model for estimating g-ratio from MRI by West, Kathryn L., Kelm, Nathaniel D., Carson, Robert P., Does, Mark D.

“…A key measure of white matter health is the g-ratio, which is defined as the ratio between the inner axon radius and the outer, myelinated, axon radius. Recent…”
Get full text

Experimental studies of g-ratio MRI in ex vivo mouse brain by West, Kathryn L., Kelm, Nathaniel D., Carson, Robert P., Alexander, Daniel C., Gochberg, Daniel F., Does, Mark D.

“…This study aimed to experimentally evaluate a previously proposed MRI method for mapping axonal g-ratio (ratio of axon diameters, measured to the inner and…”
Get full text

A novel therapy to promote axonal fusion in human digital nerves by Bamba, Ravinder, Waitayawinyu, Thanapong, Nookala, Ratnam, Riley, David Colton, Boyer, Richard B, Sexton, Kevin W, Boonyasirikool, Chinnakart, Niempoog, Sunyarn, Kelm, Nathaniel D, Does, Mark D, Dortch, Richard D, Shack, Robert Bruce, Thayer, Wesley P

“…Peripheral nerve injury can have a devastating impact on our military and veteran population. Current strategies for peripheral nerve repair include techniques…”
Get full text

4.7-T diffusion tensor imaging of acute traumatic peripheral nerve injury by Boyer, Richard B, Kelm, Nathaniel D, Riley, D Colton, Sexton, Kevin W, Pollins, Alonda C, Shack, R Bruce, Dortch, Richard D, Nanney, Lillian B, Does, Mark D, Thayer, Wesley P

“…Diagnosis and management of peripheral nerve injury is complicated by the inability to assess microstructural features of injured nerve fibers via clinical…”
Get full text

Bridging the Gap: Engineered Porcine-derived Urinary Bladder Matrix Conduits as a Novel Scaffold for Peripheral Nerve Regeneration by Nguyen, Lyly, Afshari, Ashkan, Kelm, Nathaniel D, Pollins, Alonda C, Shack, R Bruce, Does, Mark D, Thayer, Wesley P

“…PURPOSEThis study aims to compare engineered nerve conduits constructed from porcine-derived urinary bladder matrix (UBM) with the criterion-standard nerve…”
Get full text

Assessment of the Effect of Autograft Orientation on Peripheral Nerve Regeneration Using Diffusion Tensor Imaging by Afshari, Ashkan, Nguyen, Lyly, Kelm, Nathaniel D, Kim, Justine S, Cardwell, Nancy L, Pollins, Alonda C, Bamba, Ravinder, Shack, R Bruce, Does, Mark D, Thayer, Wesley P

“…PURPOSEGiven no definite consensus on the accepted autograft orientation during peripheral nerve injury repair, we compare outcomes between reverse and…”
Get full text

Immediate Enhancement of Nerve Function Using a Novel Axonal Fusion Device After Neurotmesis by Riley, David Colton, Boyer, Richard B, Deister, Curt A, Pollins, Alonda C, Cardwell, Nancy L, Kelm, Nathaniel D, Does, Mark D, Dortch, Richard D, Bamba, Ravinder, Shack, Robert Bruce, Thayer, Wesley P

“…BACKGROUNDThe management of peripheral nerve injuries remains a large challenge for plastic surgeons. With the inability to fuse axonal endings, results after…”
Get full text

A novel conduit-based coaptation device for primary nerve repair by Bamba, Ravinder, Riley, D Colton, Kelm, Nathaniel D, Cardwell, Nancy, Pollins, Alonda C, Afshari, Ashkan, Nguyen, Lyly, Dortch, Richard D, Thayer, Wesley P

“…Conduit-based nerve repairs are commonly used for small nerve gaps, whereas primary repair may be performed if there is no tension on nerve endings. We…”
Get full text

Assessment of the Effect of Autograft Orientation on Peripheral Nerve Regeneration Utilizing Diffusion Tensor Imaging by Afshari, Ashkan, MD, Nguyen, Lyly, MD, Kelm, Nathaniel D., MS, Kim, Justine S., BS, Bamba, Ravinder, MD, Cardwell, Nancy L., BS, Pollins, Alonda C., MS, Shack, Bruce, MD, Thayer, Wesley P., MD, PhD

Get full text

Engineered Porcine-derived Urinary Bladder Matrix Conduits as a Novel Scaffold for Peripheral Nerve Regeneration by Nguyen, Lyly, Afshari, Ashkan, Kelm, Nathaniel D., Pollins, Alonda C., Shack, R. Bruce, Does, Mark D., Thayer, Wesley P.

Get full text

Assessment of the Effect of Autograft Orientation on Peripheral Nerve Regeneration Utilizing Diffusion Tensor Imaging: N/A - Not a clinical study by Afshari, Ashkan, Nguyen, Lyly, Kelm, Nathaniel D., Kim, Justine S., Bamba, Ravinder, Cardwell, Nancy L., Pollins, Alonda C., Shack, Bruce, Thayer, Wesley P.

Get full text

Experimental Evaluation of Advanced Diffusion MRI Methods Towards Improved Assessment of Myelinated Neural Tissue by Kelm, Nathaniel D

Get full text