Search Results - "Kelly George"

Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration by George, Kelly L, Horne, W. Seth

“…Conspectus The prospect of recreating the complex structural hierarchy of protein folding in synthetic oligomers with backbones that are artificial in covalent…”
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The Economic Impacts of the Commercial Space Industry by Whealan George, Kelly

“…The market structure of government investment domination in the space industry is being disrupted as commercial companies began working in the commercial space…”
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Heterogeneous-Backbone Foldamer Mimics of Zinc Finger Tertiary Structure by George, Kelly L, Horne, W. Seth

“…A variety of oligomeric backbones with compositions deviating from biomacromolecules can fold in defined ways. Termed “foldamers,” these agents have diverse…”
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Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling by Maciejowski, John, George, Kelly A, Terret, Marie-Emilie, Zhang, Chao, Shokat, Kevan M, Jallepalli, Prasad V

“…The spindle assembly checkpoint (SAC) in mammals uses cytosolic and kinetochore-based signaling pathways to inhibit anaphase. In this study, we use chemical…”
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Monitoring Uncharted Communities of Crowdsourced Plagiarism by Dixon, Zachary, George, Kelly

“…This paper reports on a study of crowd-sourcing ‘study aid’ web platforms. Students are sharing completed academic coursework through a growing network of…”
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Changes in attitudes toward animals in the United States from 1978 to 2014 by George, Kelly A., Slagle, Kristina M., Wilson, Robyn S., Moeller, Steven J., Bruskotter, Jeremy T.

“…More than three decades ago, Stephen Kellert surveyed >3000 Americans to gain a better understanding of their attitudes toward wildlife. We used a web-based…”
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Preventing a boondoggle: assuring a short term research abroad activity is an educative experience by George, Kelly, Clevenger, Aaron

“…Purpose At Embry-Riddle Aeronautical University, an annual short-term, research abroad non-credit program was created in 2012 as a core component of the…”
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Using ecosystem health and welfare assessments to determine impacts of wild collection for public aquariums by Fischer, Brittany, Pempek, Jessica, George, Kelly Ann, Flint, Jaylene, Wittum, Thomas, Flint, Mark

“…Aquatic ecosystems are currently facing a multitude of stressors from anthropogenic impacts, including climate change, pollution, and overfishing. Public…”
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Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells by Tsou, Meng-Fu Bryan, Wang, Won-Jing, George, Kelly A., Uryu, Kunihiro, Stearns, Tim, Jallepalli, Prasad V.

“…It has been proposed that separase-dependent centriole disengagement at anaphase licenses centrosomes for duplication in the next cell cycle. Here we test…”
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Catching lightning in a bottle: Surveying plagiarism futures by Dixon, Zachary, George, Kelly, Carr, Tyler

“…The digitization of higher education is evolving academic misconduct, posing both new challenges to and opportunities for academic integrity and its research…”
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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication by Jones, Mathew J.K., Gelot, Camille, Munk, Stephanie, Koren, Amnon, Kawasoe, Yoshitaka, George, Kelly A., Santos, Ruth E., Olsen, Jesper V., McCarroll, Steven A., Frattini, Mark G., Takahashi, Tatsuro S., Jallepalli, Prasad V.

“…Eukaryotic genomes replicate via spatially and temporally regulated origin firing. Cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) promote origin…”
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A focus group study of Ontario dairy producer perspectives on neonatal care of male and female calves by Wilson, Devon J, Pempek, Jessica A, Roche, Steve M, Creutzinger, Katherine C, Locke, Samantha R, Habing, Gregory, Proudfoot, Kathryn L, George, Kelly A, Renaud, David L

“…Providing optimal calf care remains a challenge on many dairy farms and has important implications for the future health, welfare, and productivity of male and…”
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Pompe disease: Unmet needs and emerging therapies by George, Kelly A., Anding, Allyson L., van der Flier, Arjan, Tomassy, Giulio S., Berger, Kenneth I., Zhang, Tracy Y., Sardi, S. Pablo

“…Pompe disease is a debilitating and life-threatening disease caused by aberrant accumulation of glycogen resulting from reduced acid alpha-glucosidase…”
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Comparability of Biologics: Global Principles, Evidentiary Consistency and Unrealized Reliance by Webster, Christopher J., George, Kelly L., Woollett, Gillian R.

“…The principles of comparability assessments have been accepted globally as offering sensitive and reliable tools with which to evaluate potential changes to…”
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Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins by Yunes, Sarah A, Willoughby, Jennifer L S, Kwan, Julian H, Biagi, Jessica M, Pokharel, Niranjana, Chin, Hang Gyeong, York, Emily A, Su, Kuan-Chung, George, Kelly, Shah, Jagesh V, Emili, Andrew, Schaus, Scott E, Hansen, Ulla

“…Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising…”
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Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice by Fielder, Edward, Wan, Tengfei, Alimohammadiha, Ghazaleh, Ishaq, Abbas, Low, Evon, Weigand, B Melanie, Kelly, George, Parker, Craig, Griffin, Brigid, Jurk, Diana, Korolchuk, Viktor I, von Zglinicki, Thomas, Miwa, Satomi

“…Cancer survivors suffer from progressive frailty, multimorbidity, and premature morbidity. We hypothesise that therapy-induced senescence and senescence…”
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Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence by Willoughby, Jennifer L S, George, Kelly, Roberto, Mark P, Chin, Hang Gyeong, Stoiber, Patrick, Shin, Hyunjin, Pedamallu, Chandra Sekhar, Schaus, Scott E, Fitzgerald, Kevin, Shah, Jagesh, Hansen, Ulla

“…The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with…”
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Abiotic environmental factors influencing blowfly colonisation patterns in the field by George, Kelly A, Archer, Melanie S, Toop, Tes

“…Abstract The accuracy of minimum post-mortem interval (mPMI) estimates usually hinges upon the ability of forensic entomologists to predict the conditions…”
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Chronic UVA1 Irradiation of Human Dermal Fibroblasts: Persistence of DNA Damage and Validation of a Cell Cultured–Based Model of Photoaging by Montoni, Alicia, George, Kelly M., Soeur, Jérémie, Tran, Christian, Marrot, Laurent, Rochette, Patrick J.

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Tragic trade‐offs accompany carnivore coexistence in the modern world by Bruskotter, Jeremy T., Vucetich, John A., Gilbert, Sophie L., Carter, Neil H., George, Kelly A.

“…Two vital policy aims—biodiversity conservation and food production—are increasingly in conflict. Efforts to evaluate trade‐offs between agriculture and…”
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