Search Results - "Kelly, Una"

Regulation of age-related macular degeneration-like pathology by complement factor H by Toomey, Christopher B., Kelly, Una, Saban, Daniel R., Rickman, Catherine Bowes

“…Significance Age-related macular degeneration (AMD) affects approximately one-third of Americans over 70 and is characterized by lipoprotein-rich sub-retinal…”
Get full text

High-density lipoproteins are a potential therapeutic target for age-related macular degeneration by Kelly, Una L., Grigsby, Daniel, Cady, Martha A., Landowski, Michael, Skiba, Nikolai P., Liu, Jian, Remaley, Alan T., Klingeborn, Mikael, Bowes Rickman, Catherine

“…Strong evidence suggests that dysregulated lipid metabolism involving dysfunction of the retinal pigmented epithelium (RPE) underlies the pathogenesis of…”
Get full text

Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers by Klingeborn, Mikael, Dismuke, W. Michael, Skiba, Nikolai P., Kelly, Una, Stamer, W. Daniel, Bowes Rickman, Catherine

“…The retinal pigmented epithelium (RPE) forms the outer blood-retinal barrier in the eye and its polarity is responsible for directional secretion and uptake of…”
Get full text

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration by Ding, Jin-Dong, Johnson, Lincoln V, Herrmann, Rolf, Farsiu, Sina, Smith, Stephanie G, Groelle, Marybeth, Mace, Brian E, Sullivan, Patrick, Jamison, Jeffrey A, Kelly, Una, Harrabi, Ons, Bollini, Sangeetha Subbarao, Dilley, Jeanette, Kobayashi, Dione, Kuang, Bing, Li, Wenlin, Pons, Jaume, Lin, John C, Rickman, Catherine Bowes

“…Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), have…”
Get full text

Polarized Desmosome and Hemidesmosome Shedding via Small Extracellular Vesicles is an Early Indicator of Outer Blood-Retina Barrier Dysfunction by Hernandez, Belinda J, Skiba, Nikolai P, Plössl, Karolina, Strain, Madison, Liu, Yutao, Grigsby, Daniel, Kelly, Una, Cady, Martha A, Manocha, Vikram, Maminishkis, Arvydas, Watkins, TeddiJo, Miller, Sheldon S, Ashley-Koch, Allison, Stamer, W Daniel, Weber, Bernhard H F, Bowes Rickman, Catherine, Klingeborn, Mikael

“…The retinal pigmented epithelium (RPE) constitutes the outer blood-retinal barrier, enables photoreceptor function of the eye, and is constantly exposed to…”
Get full text

Exploring Face De-Identification using Latent Spaces by Kelly, Una M., Spreeuwers, Luuk, Veldhuis, Raymond

“…We explore a new method to hide identity information in a facial image from face recognition (FR) systems, while only minimally changing the appearance of the…”
Get full text

Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina by Yu, Ling, Kelly, Una, Ebright, Jessica N., Malek, Goldis, Saloupis, Peter, Rickman, Dennis W., McKay, Brian S., Arshavsky, Vadim Y., Bowes Rickman, Catherine

“…The phosphatase of regenerating liver-1, PRL-1, gene was detected in a screen for foveal cone photoreceptor-associated genes. It encodes a small protein…”
Get full text

Expression of the Blue-Light Receptor Cryptochrome in the Human Retina by Thompson, Carol L, Rickman, Catherine Bowes, Shaw, Steven J, Ebright, Jessica N, Kelly, Una, Sancar, Aziz, Rickman, Dennis W

“…To analyze the patterns of expression of the cryptochromes, CRY1 and CRY2, in the human retina and to correlate expression of these putative blue-light…”
Get full text

Estimating Canopy Height at Scale by Pauls, Jan, Zimmer, Max, Kelly, Una M, Schwartz, Martin, Saatchi, Sassan, Ciais, Philippe, Pokutta, Sebastian, Brandt, Martin, Gieseke, Fabian

“…We propose a framework for global-scale canopy height estimation based on satellite data. Our model leverages advanced data preprocessing techniques, resorts…”
Get full text

Gender Obfuscation through Face Morphing by Wang, Shunxin, Kelly, Una M., Veldhuis, Raymond N.J.

“…With the advancement of machine learning, facial biometric data has been widely adopted for person recognition. Soft biometrics such as gender, age and…”
Get full text

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice by Landowski, Michael, Kelly, Una, Klingeborn, Mikael, Groelle, Marybeth, Ding, Jin-Dong, Grigsby, Daniel, Rickman, Catherine Bowes

“…One of the strongest susceptibility genes for age-related macular degeneration (AMD) is complement factor H (CFH); however, its impact on AMD pathobiology…”
Get full text

AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model by Grigsby, Daniel, Klingeborn, Mikael, Kelly, Una, Chew, Lindsey A, Asokan, Aravind, Devlin, Garth, Smith, Sharon, Keyes, Lisa, Timmers, Adrian, Scaria, Abraham, Bowes Rickman, Catherine

“…Complement dysregulation in the eye has been implicated in the pathogenesis of age-related macular degeneration (AMD), and genetic variants of complement…”
Get full text

Expression of Human Complement Factor H Prevents Age-Related Macular Degeneration–Like Retina Damage and Kidney Abnormalities in Aged Cfh Knockout Mice by Ding, Jin-Dong, Kelly, Una, Landowski, Michael, Toomey, Christopher B, Groelle, Marybeth, Miller, Chelsey, Smith, Stephanie G, Klingeborn, Mikael, Singhapricha, Terry, Jiang, Haixiang, Frank, Michael M, Bowes Rickman, Catherine

“…Complement factor H (CFH) is an important regulatory protein in the alternative pathway of the complement system, and CFH polymorphisms increase the genetic…”
Get full text

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration by Toomey, Christopher B, Landowski, Michael, Klingeborn, Mikael, Kelly, Una, Deans, John, Dong, Holly, Harrabi, Ons, Van Blarcom, Thomas, Yeung, Yik Andy, Grishanin, Ruslan, Lin, John C, Saban, Daniel R, Bowes Rickman, Catherine

“…A large body of evidence supports a central role for complement activation in the pathobiology of age-related macular degeneration (AMD), including plasma…”
Get full text

Author Correction: Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers by Klingeborn, Mikael, Dismuke, W. Michael, Skiba, Nikolai P., Kelly, Una, Stamer, W. Daniel, Bowes Rickman, Catherine

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper…”
Get full text

Nb3Sn Wire Shape and Cross-Sectional Area Inhomogeneity in Rutherford Cables by Kelly, Una M., Richter, Sven, Redenbach, Claudia, Schladitz, Katja, Scheuerlein, Christian, Wolf, Felix, Ebermann, Patrick, Lackner, Friedrich, Schoerling, Daniel, Meinel, Dietmar

“…During Rutherford cable production, the wires are plastically deformed and their initially round shape is distorted. Using X-ray absorption tomography, we have…”
Get full text

The role of complement dysregulation in AMD mouse models by Ding, Jin-Dong, Kelly, Una, Groelle, Marybeth, Christenbury, Joseph G, Zhang, Wenlan, Bowes Rickman, Catherine

“…Variations in several complement genes are now known to be significant risk factors for the development of age-related macular degeneration (AMD). Despite…”
Get more information

Nb 3 Sn Wire Shape and Cross-Sectional Area Inhomogeneity in Rutherford Cables by Kelly, Una M., Richter, Sven, Redenbach, Claudia, Schladitz, Katja, Scheuerlein, Christian, Wolf, Felix, Ebermann, Patrick, Lackner, Friedrich, Schoerling, Daniel, Meinel, Dietmar

Get full text

Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration by Kelly, Una, Yu, Ling, Kumar, Pallavi, Ding, Jin-Dong, Jiang, Haixiang, Hageman, Gregory S, Arshavsky, Vadim Y, Frank, Michael M, Hauser, Michael A, Rickman, Catherine Bowes

“…An imbalance between activation and inhibition of the complement system has been implicated in the etiologies of numerous common diseases. Allotypic variants…”
Get full text

Development of humanized complement factor H transgenic mice to interrogate the effect of age-related macular degeneration risk associated variants in vivo by Kelly, Una, Ding, Jin-dong, Landowski, Michael, Groelle, Marybeth, Jiang, Haixiang, Skiba, Nikolai, Frank, Michael, Rickman, Catherine Bowes

Get full text