Search Results - "Kelly, S. J."

structural basis of yeast prion strain variants by Toyama, B.H, Kelly, M.J.S, Gross, J.D, Weissman, J.S

“…Among the many surprises to arise from studies of prion biology, perhaps the most unexpected is the strain phenomenon whereby a single protein can misfold into…”
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Allosteric N-WASP activation by an inter-SH3 domain linker in Nck by Okrut, Julia, Prakash, Sumit, Wu, Qiong, Kelly, Mark J. S., Taunton, Jack

“…Actin filament networks assemble on cellular membranes in response to signals that locally activate neural Wiskott–Aldrich-syndrome protein (N-WASP) and the…”
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Expanding the space of protein geometries by computational design of de novo fold families by Pan, Xingjie, Thompson, Michael C, Zhang, Yang, Liu, Lin, Fraser, James S, Kelly, Mark J S, Kortemme, Tanja

“…Naturally occurring proteins vary the precise geometries of structural elements to create distinct shapes optimal for function. We present a computational…”
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Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A by Longbotham, James E., Kelly, Mark J. S., Fujimori, Danica Galonić

“…PHD reader domains are chromatin binding modules often responsible for the recruitment of large protein complexes that contain histone modifying enzymes,…”
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The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles by Citron, Y Rose, Fagerstrom, Carey J, Keszthelyi, Bettina, Huang, Bo, Rusan, Nasser M, Kelly, Mark J S, Agard, David A

“…The centrosome serves as the main microtubule-organizing center in metazoan cells, yet despite its functional importance, little is known mechanistically about…”
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They Came From the Pacific: How Changing Arctic Currents Could Contribute to an Ecological Regime Shift in the Atlantic Ocean by Kelly, S. J., Popova, E., Aksenov, Y., Marsh, R., Yool, A.

“…The Arctic Ocean is rapidly changing. With warming waters, receding sea ice, and changing circulation patterns, it has been hypothesized that previously closed…”
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On the Origin of Water Masses in the Beaufort Gyre by Kelly, S. J., Proshutinsky, A., Popova, E. K., Aksenov, Y. K., Yool, A.

“…The Beaufort Gyre is a key feature of the Arctic Ocean, acting as a reservoir for freshwater in the region. Depending on whether the prevailing atmospheric…”
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Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death by KERR, L. E, BIRSE-ARCHBOLD, J.-L. A, SHARKEY, J, SHORT, D. M, MCGREGOR, A. L, HERON, I, MACDONALD, D. C, THOMPSON, J, CARLSON, G. J, KELLY, J. S, MCCULLOCH, J

“…The proapoptotic B-cell lymphoma-2 family protein Bax is a key regulatory point in the intrinsic apoptotic pathway. However, the factors controlling the…”
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Associations of morbidity in the underweight by Kelly, S.J, Lilley, J.M, Leonardi-Bee, J

“…Background/Objectives: There is little research on the demographic characteristics and morbidity of people categorized as ‘underweight’ from their body mass…”
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Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices by JIANYING ZENG, JIA LIU, YANG, Guo-Yuan, KELLY, Mark J. S, JAMES, Thomas L, LITT, Lawrence

“…Exogenous pyruvate and ethyl pyruvate (EP), the key ingredient in a new Ringer's solution in clinical trials, are antioxidants as well as metabolic substrates…”
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Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling by Srivastava, J, Barreiro, G, Groscurth, S, Gingras, A.R, Goult, B.T, Critchley, D.R, Kelly, M.J.S, Jacobson, M.P, Barber, D.L

“…Actin filament binding by the focal adhesion (FA)-associated protein talin stabilizes cell-substrate adhesions and is thought to be rate-limiting in cell…”
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Variability in tracheal mucociliary transport is not controlled by beating cilia in lambs in vivo during ventilation with humidified and nonhumidified air by Kelly, S J, Brodecky, V, Skuza, E M, Berger, P J, Tatkov, S

“…Mucociliary transport in the respiratory epithelium depends on beating of cilia to move a mucus layer containing trapped inhaled particles toward the mouth…”
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Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites by Liu, Jia, Litt, Lawrence, Segal, Mark R, Kelly, Mark J S, Pelton, Jeffrey G, Kim, Myungwon

“…Aerobic metabolism occurs in a background of oxygen radicals and reactive oxygen species (ROS) that originate from the incomplete reduction of molecular oxygen…”
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Effects of prenatal alcohol exposure on social behavior in humans and other species by Kelly, Sandra J., Day, Nancy, Streissguth, Ann P.

“…Alcohol exposure during development causes central nervous system alterations in both humans and animals. Although the most common behavioral manifestation of…”
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Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions by Pfaff, Samuel J, Chimenti, Michael S, Kelly, Mark J S, Arkin, Michelle R

“…Fragment-based lead discovery complements high-throughput screening and computer-aided drug design for the discovery of small-molecule inhibitors of…”
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Elucidating the Mechanism of Substrate Recognition by the Bacterial Hsp90 Molecular Chaperone by Street, Timothy O., Zeng, Xiaohui, Pellarin, Riccardo, Bonomi, Massimiliano, Sali, Andrej, Kelly, Mark J.S., Chu, Feixia, Agard, David A.

“…Hsp90 is a conformationally dynamic molecular chaperone known to promote the folding and activation of a broad array of protein substrates (“clients”). Hsp90…”
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Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding by Frantz, Christian, Barreiro, Gabriela, Dominguez, Laura, Chen, Xiaoming, Eddy, Robert, Condeelis, John, Kelly, Mark J.S, Jacobson, Matthew P, Barber, Diane L

“…Newly generated actin free barbed ends at the front of motile cells provide sites for actin filament assembly driving membrane protrusion. Growth factors…”
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Effects of alcohol exposure during development on social behavior in rats by Lugo, J.N, Marino, M.D, Cronise, K, Kelly, S.J

“…In addition to the cognitive deficits associated with fetal alcohol syndrome (FAS), clinical and animal studies indicate that alcohol exposure might also have…”
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Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening by Ortiz, Gloria, Longbotham, James E, Qin, Sophia L, Zhang, Meng Yao, Lee, Gregory M, Neitz, R. Jeffrey, Kelly, Mark J. S, Arkin, Michelle R, Fujimori, Danica Galoni

“…PHD fingers are a type of chromatin reader that primarily recognize chromatin as a function of lysine methylation state. Dysregulated PHD fingers are…”
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Comparison of Social Abilities of Children with Fetal Alcohol Syndrome to Those of Children with Similar IQ Scores and Normal Controls by Thomas, Suzanne E., Kelly, Sandra J., Mattson, Sarah N., Riley, Edward P.

“…Children diagnosed with fetal alcohol syndrome (FAS) were assessed with items from the social skills domain of the Vineland Adaptive Behavior Scales (VABS) via…”
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