Search Results - "Kelly, Rachel"

Metabolomics, physical activity, exercise and health: A review of the current evidence by Kelly, Rachel S., Kelly, Michael P., Kelly, Paul

“…Physical activity (PA) and exercise are among the most important determinants of health. However, PA is a complex and heterogeneous behavior and the biological…”
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Asthma Metabolomics and the Potential for Integrative Omics in Research and the Clinic by Kelly, Rachel S., PhD, Dahlin, Amber, PhD, MMSc, McGeachie, Michael J., PhD, Qiu, Weiliang, PhD, Sordillo, Joanne, PhD, Wan, Emily S., MD, Wu, Ann Chen, MD, Lasky-Su, Jessica, ScD

“…Asthma is a complex disease well-suited to metabolomic profiling, both for the development of novel biomarkers and for the improved understanding of…”
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The Ku complex: recent advances and emerging roles outside of non-homologous end-joining by Abbasi, Sanna, Parmar, Gursimran, Kelly, Rachel D., Balasuriya, Nileeka, Schild-Poulter, Caroline

“…Since its discovery in 1981, the Ku complex has been extensively studied under multiple cellular contexts, with most work focusing on Ku in terms of its…”
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Metabolomics and lipidomics strategies in modern drug discovery and development by Astarita, Giuseppe, Kelly, Rachel S., Lasky-Su, Jessica

“…•Review covering application of metabolomics and lipidomics throughout the drug discovery and development process.•Focus on basic research, target…”
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Ambient PM2.5 species and ultrafine particle exposure and their differential metabolomic signatures by Nassan, Feiby L., Wang, Cuicui, Kelly, Rachel S., Lasky-Su, Jessica A., Vokonas, Pantel S., Koutrakis, Petros, Schwartz, Joel D.

“…•Metabolomic profiling is a powerful tool for mechanistic understanding of PM2.5 exposure impact.•PM2.5 exposure has metabolomic signatures related to…”
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Life-course socioeconomic status and DNA methylation of genes regulating inflammation by Stringhini, Silvia, Polidoro, Silvia, Sacerdote, Carlotta, Kelly, Rachel S, van Veldhoven, Karin, Agnoli, Claudia, Grioni, Sara, Tumino, Rosario, Giurdanella, Maria Concetta, Panico, Salvatore, Mattiello, Amalia, Palli, Domenico, Masala, Giovanna, Gallo, Valentina, Castagné, Raphaële, Paccaud, Fred, Campanella, Gianluca, Chadeau-Hyam, Marc, Vineis, Paolo

“…In humans, low socioeconomic status (SES) across the life course is associated with greater diurnal cortisol production, increased inflammatory activity and…”
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Biologic therapies for asthma in underserved populations by Kelly, Rachel S, Weiss, Scott T

“…[...]the identification of novel therapeutic strategies represents an important unmet need for underserved Black and Hispanic children living in urban areas.4…”
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The multifaceted role of GCM1 during trophoblast differentiation in the human placenta by Jeyarajah, Mariyan J, Jaju Bhattad, Gargi, Kelly, Rachel D, Baines, Kelly J, Jaremek, Adam, Yang, Fei-Hung P, Okae, Hiroaki, Arima, Takahiro, Dumeaux, Vanessa, Renaud, Stephen J

“…Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a critical aspect of human placentation. Insufficient EVT invasion can…”
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Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence by Kelly, Rachel S, Vander Heiden, Matthew G, Giovannucci, Edward, Mucci, Lorelei A

“…Metabolite profiling is being increasing employed in the study of prostate cancer as a means of identifying predictive, diagnostic, and prognostic biomarkers…”
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The maternal prenatal and offspring early‐life gut microbiome of childhood asthma phenotypes by Lee‐Sarwar, Kathleen A., Chen, Yih‐Chieh, Chen, Yuan Yao, Kozyrskyj, Anita L., Mandhane, Piush J., Turvey, Stuart E., Subbarao, Padmaja, Bisgaard, Hans, Stokholm, Jakob, Chawes, Bo, Sørensen, Søren J., Kelly, Rachel S., Lasky‐Su, Jessica, Zeiger, Robert S., O'Connor, George T., Sandel, Megan T., Bacharier, Leonard B., Beigelman, Avraham, Carey, Vincent J., Harshfield, Benjamin J., Laranjo, Nancy, Gold, Diane R., Weiss, Scott T., Litonjua, Augusto A.

“…Background The infant fecal microbiome is known to impact subsequent asthma risk, but the environmental exposures impacting this association, the role of the…”
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Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma by Dahlin, Amber, Sordillo, Joanne E, McGeachie, Michael, Kelly, Rachel S, Tantisira, Kelan G, Lutz, Sharon M, Lasky-Su, Jessica, Wu, Ann Chen

“…While genome-wide association studies have identified genes involved in differential treatment responses to inhaled corticosteroids (ICS) in asthma, few…”
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Metabolomic signatures of the long-term exposure to air pollution and temperature by Nassan, Feiby L, Kelly, Rachel S, Kosheleva, Anna, Koutrakis, Petros, Vokonas, Pantel S, Lasky-Su, Jessica A, Schwartz, Joel D

“…Long-term exposures to air pollution has been reported to be associated with inflammation and oxidative stress. However, the underlying metabolic mechanisms…”
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The emergence of social licence necessitates reforms in environmental regulation by van Putten, Ingrid E., Cvitanovic, Christopher, Fulton, Elizabeth, Lacey, Justine, Kelly, Rachel

“…The term “social licence to operate” (SLO), popularized in corporate usage over the last 20 years, is frequently used to refer to the level of social approval…”
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Social license through citizen science: a tool for marine conservation by Kelly, Rachel, Fleming, Aysha, Pecl, Gretta T., Richter, Anett, Bonn, Aletta

“…Active and meaningful public engagement is necessary to foster informed and publicly accepted natural resource management. Citizen science presents an…”
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Functional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students by Dager, Alecia D., Anderson, Beth M., Rosen, Rivkah, Khadka, Sabin, Sawyer, Broderick, Jiantonio-Kelly, Rachel E., Austad, Carol S., Raskin, Sarah A., Tennen, Howard, Wood, Rebecca M., Fallahi, Carolyn R., Pearlson, Godfrey D.

“…Background and Aims Young adults show the highest rates of escalating drinking, yet the neural risk mechanisms remain unclear. Heavy drinkers show variant…”
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Human Plasma Metabolomics Study across All Stages of Age-Related Macular Degeneration Identifies Potential Lipid Biomarkers by Laíns, Inês, Kelly, Rachel S., Miller, John B., Silva, Rufino, Vavvas, Demetrios G., Kim, Ivana K., Murta, Joaquim N., Lasky-Su, Jessica, Miller, Joan W., Husain, Deeba

“…To characterize the plasma metabolomic profile of patients with age-related macular degeneration (AMD) using mass spectrometry (MS). Cross-sectional…”
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Integrative analysis of the intestinal metabolome of childhood asthma by Lee-Sarwar, Kathleen A., Kelly, Rachel S., Lasky-Su, Jessica, Zeiger, Robert S., O'Connor, George T., Sandel, Megan T., Bacharier, Leonard B., Beigelman, Avraham, Laranjo, Nancy, Gold, Diane R., Weiss, Scott T., Litonjua, Augusto A.

“…The intestinal metabolome reflects the biological consequences of diverse exposures and might provide insight into asthma pathophysiology. We sought to perform…”
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Drink driving engagement in women: An exploration of context, hazardous alcohol use, and behaviour by Armstrong, Kerry A, Freeman, James E, Davey, Jeremy D, Kelly, Rachel L

“…While drink driving continues to be significantly more common among male drivers, there is evidence from many countries that shows a growing trend of women…”
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The metabolic role of vitamin D in children’s neurodevelopment: a network study by De Marzio, Margherita, Lasky-Su, Jessica, Chu, Su H., Prince, Nicole, Litonjua, Augusto A., Weiss, Scott T., Kelly, Rachel S., Glass, Kimberly R.

“…Neurodevelopmental disorders are rapidly increasing in prevalence and have been linked to various environmental risk factors. Mounting evidence suggests a…”
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Association of Prenatal Maternal and Infant Vitamin D Supplementation with Offspring Asthma by Ramirez, Lourdes G, Lee-Sarwar, Kathleen, Kelly, Rachel S, Weiss, Scott T, Litonjua, Augusto A

“…The role and timing of vitamin D supplementation in the prevention of asthma has not been fully elucidated. To describe the association between prenatal and…”
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