Search Results - "Kelly, Neil J."

Pulmonary Arterial Hypertension: Emerging Principles of Precision Medicine across Basic Science to Clinical Practice by Kelly, Neil J, Chan, Stephen Y

“…Pulmonary arterial hypertension (PAH) is an enigmatic and deadly vascular disease with no known cure. Recent years have seen rapid advances in our…”
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Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-induced Redox Signaling and Human Endothelial Cell Activation by Lubos, Edith, Kelly, Neil J., Oldebeken, Scott R., Leopold, Jane A., Zhang, Ying-Yi, Loscalzo, Joseph, Handy, Diane E.

“…Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant enzyme, the deficiency of which promotes atherogenesis. Accordingly, we examined the mechanisms by…”
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Omics and Extreme Phenotyping Reveal Longitudinal Association Between Left Atrial Size and Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension by Kelly, Neil J, Newhouse, David, Chapagain, Himal, Patel, Ashish, Tang, Yicheng, Howard, Ato, Kirillova, Anna, Kim, Hee-Jung J, Rahman, Haris, El Khoury, Wadih, Nouraie, Seyed Mehdi, Hickey, Gavin, Sade, Leyla Elif, Jain, Sandeep, Chan, Stephen Y

“…Left heart disease is the most common cause of pulmonary hypertension (PH) and is frequently accompanied by increases in pulmonary vascular resistance…”
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Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension by Hafeez, Neha, Kirillova, Anna, Yue, Yunshan, Rao, Rashmi J, Kelly, Neil J, El Khoury, Wadih, Al Aaraj, Yassmin, Tai, Yi-Yin, Handen, Adam, Tang, Ying, Jiang, Danli, Wu, Ting, Zhang, Yingze, McNamara, Dennis, Kudryashova, Tatiana V, Goncharova, Elena A, Goncharov, Dmitry, Bertero, Thomas, Nouraie, Mehdi, Li, Gang, Sun, Wei, Chan, Stephen Y

“…Background Pulmonary arterial hypertension (PAH) is a complex, fatal disease where disease severity has been associated with the single nucleotide polymorphism…”
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Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction by Meng, Qingqing, Lai, Yen-Chun, Kelly, Neil J, Bueno, Marta, Baust, Jeffrey J, Bachman, Timothy N, Goncharov, Dmitry, Vanderpool, Rebecca R, Radder, Josiah E, Hu, Jian, Goncharova, Elena, Morris, Alison M, Mora, Ana L, Shapiro, Steven D, Gladwin, Mark T

“…Pulmonary hypertension (PH) associated with heart failure with preserved ejection fraction (PH-HFpEF; World Health Organization Group II) secondary to left…”
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Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction by Radder, Josiah E, Zhang, Yingze, Gregory, Alyssa D, Yu, Shibing, Kelly, Neil J, Leader, Joseph K, Kaminski, Naftali, Sciurba, Frank C, Shapiro, Steven D

“…Genetic association studies in chronic obstructive pulmonary disease have primarily tested for association with common variants, the results of which explain…”
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension by Tai, Yi-Yin, Yu, Qiujun, Tang, Ying, Sun, Wei, Kelly, Neil J, Okawa, Satoshi, Zhao, Jingsi, Schwantes-An, Tae-Hwi, Lacoux, Caroline, Torrino, Stephanie, Al Aaraj, Yassmin, El Khoury, Wadih, Negi, Vinny, Liu, Mingjun, Corey, Catherine G, Belmonte, Frances, Vargas, Sara O, Schwartz, Brian, Bhat, Bal, Chau, B Nelson, Karnes, Jason H, Satoh, Taijyu, Barndt, Robert J, Wu, Haodi, Parikh, Victoria N, Wang, Jianrong, Zhang, Yingze, McNamara, Dennis, Li, Gang, Speyer, Gil, Wang, Bing, Shiva, Sruti, Kaufman, Brett, Kim, Seungchan, Gomez, Delphine, Mari, Bernard, Cho, Michael H, Boueiz, Adel, Pauciulo, Michael W, Southgate, Laura, Trembath, Richard C, Sitbon, Olivier, Humbert, Marc, Graf, Stefan, Morrell, Nicholas W, Rhodes, Christopher J, Wilkins, Martin R, Nouraie, Mehdi, Nichols, William C, Desai, Ankit A, Bertero, Thomas, Chan, Stephen Y

“…Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial…”
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Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain by Dandachi, Nadine, Kelly, Neil J, Wood, John P, Burton, Christine L, Radder, Josiah E, Leme, Adriana S, Gregory, Alyssa D, Shapiro, Steven D

“…Macrophage elastase (matrix metalloproteinase [MMP]-12) is a potent protease that contributes to the lung destruction that accompanies cigarette smoking; it…”
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Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility by Radder, Josiah E, Gregory, Alyssa D, Leme, Adriana S, Cho, Michael H, Chu, Yanxia, Kelly, Neil J, Bakke, Per, Gulsvik, Amund, Litonjua, Augusto A, Sparrow, David, Beaty, Terri H, Crapo, James D, Silverman, Edwin K, Zhang, Yingze, Berndt, Annerose, Shapiro, Steven D

“…Chronic obstructive pulmonary disease (COPD) is caused by a complex interaction of environmental exposures, most commonly cigarette smoke, and genetic factors…”
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Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor by Kelly, Neil J, Radder, Josiah E, Baust, Jeffrey J, Burton, Christine L, Lai, Yen-Chun, Potoka, Karin C, Agostini, Brittani A, Wood, John P, Bachman, Timothy N, Vanderpool, Rebecca R, Dandachi, Nadine, Leme, Adriana S, Gregory, Alyssa D, Morris, Alison, Mora, Ana L, Gladwin, Mark T, Shapiro, Steven D

“…Pulmonary hypertension (PH) is associated with features of obesity and metabolic syndrome that translate to the induction of PH by chronic high-fat diet (HFD)…”
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PPARγ in emphysema: blunts the damage and triggers repair? by Kelly, Neil J, Shapiro, Steven D

“…Cigarette smoke is the most common cause of pulmonary emphysema, which results in an irreversible loss of lung structure and function. Th1 and Th17 immune…”
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Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking by Tsuji, Takao, Kelly, Neil J, Takahashi, Saeko, Leme, Adriana S, Houghton, A McGarry, Shapiro, Steven D

“…Macrophage elastase (MMP12) is a key mediator of cigarette smoke (CS)-induced emphysema, yet its role in other smoking related pathologies remains unclear. The…”
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SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension by Sun, Wei, Tang, Ying, Tai, Yi-Yin, Handen, Adam, Zhao, Jingsi, Speyer, Gil, Al Aaraj, Yassmin, Watson, Annie, Romanelli, Makenna E, Sembrat, John, Rojas, Mauricio, Simon, Marc A, Zhang, Yingze, Lee, Janet, Xiong, Zeyu, Dutta, Partha, Vasamsetti, Sathish Badu, McNamara, Dennis, McVerry, Bryan, McTiernan, Charles F, Sciurba, Frank C, Kim, Seungchan, Smith, Kerri Akaya, Mazurek, Jeremy A, Han, Yuchi, Vaidya, Anjali, Nouraie, Seyed Mehdi, Kelly, Neil J, Chan, Stephen Y

“…Utilizing publicly available ribonucleic acid sequencing data, we identified as a BMPR2-related gene differentially expressed between induced pluripotent stem…”
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Automated Measurement of Blood Vessels in Tissues from Microscopy Images by Kelly, Neil J, Dandachi, Nadine, Goncharov, Dmitry A, Pena, Andressa Z, Radder, Josiah E, Gregory, Alyssa D, Lai, Yen-Chun, Leme, Adriana S, Gladwin, Mark T, Goncharova, Elena A, St Croix, Claudette M, Shapiro, Steven D

“…The quantification of tunica media thickness in histological cross sections is a ubiquitous exercise in cardiopulmonary research, yet the methods for…”
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PPAR[gamma] in emphysema: blunts the damage and triggers repair? by Kelly, Neil J, Shapiro, Steven D

“…Cigarette smoke is the most common cause of pulmonary emphysema, which results in an irreversible loss of lung structure and function. Th1 and Th17 immune…”
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SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function by Sun, Wei, Tang, Ying, Tai, Yi-Yin, Handen, Adam, Zhao, Jingsi, Speyer, Gil, Al Aaraj, Yassmin, Watson, Annie, Romanelli, Makenna E., Sembrat, John, Rojas, Mauricio, Simon, Marc A., Zhang, Yingze, Lee, Janet, Xiong, Zeyu, Dutta, Partha, Vasamsetti, Sathish Badu, McNamara, Dennis, McVerry, Bryan, McTiernan, Charles F., Sciurba, Frank C., Kim, Seungchan, Smith, Kerri Akaya, Mazurek, Jeremy A., Han, Yuchi, Vaidya, Anjali, Nouraie, Seyed Mehdi, Kelly, Neil J., Chan, Stephen Y.

“…[Display omitted] •Guided by public sequencing data of iPSC-derived BMPR2-mutant ECs derived from patients with PAH and related family members, SCUBE1 was…”
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Abstract 4913: Glutathione Peroxidase-1 Modulates the Effects of Tumor Necrosis Factor-alpha in Endothelial Cells by Regulating Dual Specificity Phosphatase 4 by Lubos, Edith, Kelly, Neil J, Leopold, Jane A, Zhang, Ying-Yi, Loscalzo, Joseph, Handy, Diane E

“…Abstract only Reactive oxygen species (ROS) have been implicated in pro-inflammatory signal transduction activated by tumor necrosis factor- α (TNF- α ). For…”
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Vascular Remodeling in Pulmonary Hypertension by Kelly, Neil J

“…Pulmonary hypertension (PH) is a rare but deadly disease whose victims bear a 40% chance of mortality within the first five years of diagnosis. Although…”
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