Search Results - "Kelly, Mark J.S."

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding by Frantz, Christian, Barreiro, Gabriela, Dominguez, Laura, Chen, Xiaoming, Eddy, Robert, Condeelis, John, Kelly, Mark J.S, Jacobson, Matthew P, Barber, Diane L

“…Newly generated actin free barbed ends at the front of motile cells provide sites for actin filament assembly driving membrane protrusion. Growth factors…”
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Computational design of a modular protein sense-response system by Glasgow, Anum A, Huang, Yao-Ming, Mandell, Daniel J, Thompson, Michael, Ritterson, Ryan, Loshbaugh, Amanda L, Pellegrino, Jenna, Krivacic, Cody, Pache, Roland A, Barlow, Kyle A, Ollikainen, Noah, Jeon, Deborah, Kelly, Mark J S, Fraser, James S, Kortemme, Tanja

“…Sensing and responding to signals is a fundamental ability of living systems, but despite substantial progress in the computational design of new protein…”
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A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells by Stöhr, Jan, Wu, Haifan, Nick, Mimi, Wu, Yibing, Bhate, Manasi, Condello, Carlo, Johnson, Noah, Rodgers, Jeffrey, Lemmin, Thomas, Acharya, Srabasti, Becker, Julia, Robinson, Kathleen, Kelly, Mark J. S., Gai, Feng, Stubbs, Gerald, Prusiner, Stanley B., DeGrado, William F.

“…The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer's. There is considerable interest in…”
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Design of a Phosphorylatable PDZ Domain with Peptide-Specific Affinity Changes by Smith, Colin A., Shi, Catherine A., Chroust, Matthew K., Bliska, Thomas E., Kelly, Mark J.S., Jacobson, Matthew P., Kortemme, Tanja

“…Phosphorylation is one of the most common posttranslational modifications controlling cellular protein activity. Here, we describe a combined computational and…”
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Radically Different Amyloid Conformations Dictate the Seeding Specificity of a Chimeric Sup35 Prion by Foo, Catherine K., Ohhashi, Yumiko, Kelly, Mark J.S., Tanaka, Motomasa, Weissman, Jonathan S.

“…A remarkable feature of prion biology is that the same prion protein can misfold into more than one infectious conformation, and these conformations in turn…”
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Similarities between the spectrin SH3 domain denatured state and its folding transition state by Kortemme, Tanja, Kelly, Mark J.S, Kay, Lewis E, Forman-Kay, Julie, Serrano, Luis

“…We have expanded our description of the energy landscape for folding of the SH3 domain of chicken α-spectrin by a detailed structural characterization of its…”
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Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations by Ugur, Fatima S., Kelly, Mark J.S., Fujimori, Danica Galonić

“…[Display omitted] •Dysregulation of KDM5C in X-linked intellectual disability is poorly understood.•ARID domain of KDM5C aids nucleosome demethylation, while…”
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A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain by Lin King, John V., Emrick, Joshua J., Kelly, Mark J.S., Herzig, Volker, King, Glenn F., Medzihradszky, Katalin F., Julius, David

“…TRPA1 is a chemosensory ion channel that functions as a sentinel for structurally diverse electrophilic irritants. Channel activation occurs through an unusual…”
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Expanding the space of protein geometries by computational design of de novo fold families by Pan, Xingjie, Thompson, Michael C, Zhang, Yang, Liu, Lin, Fraser, James S, Kelly, Mark J S, Kortemme, Tanja

“…Naturally occurring proteins vary the precise geometries of structural elements to create distinct shapes optimal for function. We present a computational…”
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Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism by Torres, Idelisse Ortiz, Kuchenbecker, Kristopher M., Nnadi, Chimno I., Fletterick, Robert J., Kelly, Mark J. S., Fujimori, Danica Galonić

“…The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of…”
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Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A by Longbotham, James E., Kelly, Mark J. S., Fujimori, Danica Galonić

“…PHD reader domains are chromatin binding modules often responsible for the recruitment of large protein complexes that contain histone modifying enzymes,…”
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Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy by Peacock, D. Matthew, Kelly, Mark J. S., Shokat, Kevan M.

“…While there has been recent success in the development of KRasG12C inhibitors, unmet needs for selective inhibitors of KRasG12D and the remaining oncogenic…”
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structural basis of yeast prion strain variants by Toyama, B.H, Kelly, M.J.S, Gross, J.D, Weissman, J.S

“…Among the many surprises to arise from studies of prion biology, perhaps the most unexpected is the strain phenomenon whereby a single protein can misfold into…”
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Systems-level effects of allosteric perturbations to a model molecular switch by Perica, Tina, Mathy, Christopher J. P., Xu, Jiewei, Jang, Gwendolyn Μ., Zhang, Yang, Kaake, Robyn, Ollikainen, Noah, Braberg, Hannes, Swaney, Danielle L., Lambright, David G., Kelly, Mark J. S., Krogan, Nevan J., Kortemme, Tanja

“…Molecular switch proteins whose cycling between states is controlled by opposing regulators 1 , 2 are central to biological signal transduction. As switch…”
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Elucidating the Mechanism of Substrate Recognition by the Bacterial Hsp90 Molecular Chaperone by Street, Timothy O., Zeng, Xiaohui, Pellarin, Riccardo, Bonomi, Massimiliano, Sali, Andrej, Kelly, Mark J.S., Chu, Feixia, Agard, David A.

“…Hsp90 is a conformationally dynamic molecular chaperone known to promote the folding and activation of a broad array of protein substrates (“clients”). Hsp90…”
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Outcome-related metabolomic patterns from H P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia

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Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening by Ortiz, Gloria, Longbotham, James E, Qin, Sophia L, Zhang, Meng Yao, Lee, Gregory M, Neitz, R. Jeffrey, Kelly, Mark J. S, Arkin, Michelle R, Fujimori, Danica Galoni

“…PHD fingers are a type of chromatin reader that primarily recognize chromatin as a function of lysine methylation state. Dysregulated PHD fingers are…”
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Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites by Liu, Jia, Litt, Lawrence, Segal, Mark R, Kelly, Mark J S, Pelton, Jeffrey G, Kim, Myungwon

“…Aerobic metabolism occurs in a background of oxygen radicals and reactive oxygen species (ROS) that originate from the incomplete reduction of molecular oxygen…”
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Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions by Pfaff, Samuel J, Chimenti, Michael S, Kelly, Mark J S, Arkin, Michelle R

“…Fragment-based lead discovery complements high-throughput screening and computer-aided drug design for the discovery of small-molecule inhibitors of…”
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1 H/ 13 C NMR metabolomics in a neonatal rat brain slice model of early and late mild hypothermia treatments of asphyxia by Liu, Jia, Litt, Lawrence, Pelton, Jeffrey G., Segal, Mark, Kelly, Mark J.S., Kim, Myungwon, James, Thomas L.

“…Abstract only Clinical trials with neurological outcomes have led to using mild therapeutic hypothermia (≈4°C decrease) in early treatments of newborns with…”
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