Search Results - "Kelly, Kindra M"

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense by Scumpia, Philip O, Botten, Giovanni A, Norman, Joshua S, Kelly-Scumpia, Kindra M, Spreafico, Roberto, Ruccia, Amber R, Purbey, Prabhat K, Thomas, Brandon J, Modlin, Robert L, Smale, Stephen T

“…Successful host defense against pathogens requires innate immune recognition of the correct pathogen associated molecular patterns (PAMPs) by pathogen…”
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Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8 by Vollmer, Jörg, Tluk, Sibylle, Schmitz, Claudia, Hamm, Svetlana, Jurk, Marion, Forsbach, Alexandra, Akira, Shizuo, Kelly, Kindra M, Reeves, Westley H, Bauer, Stefan, Krieg, Arthur M

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies to certain cellular macromolecules, such as the…”
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Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine by Miwa, Hiromi, Antao, Olivia Q, Kelly-Scumpia, Kindra M, Baghdasarian, Sevana, Mayer, Daniel P, Shang, Lily, Sanchez, Gina M, Archang, Maani M, Scumpia, Philip O, Weinstein, Jason S, Di Carlo, Dino

“…New vaccine platforms that activate humoral immunity and generate neutralizing antibodies are required to combat emerging pathogens, including influenza virus…”
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A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy by Madigan, Cressida A., Cambier, C.J., Kelly-Scumpia, Kindra M., Scumpia, Philip O., Cheng, Tan-Yun, Zailaa, Joseph, Bloom, Barry R., Moody, D. Branch, Smale, Stephen T., Sagasti, Alvaro, Modlin, Robert L., Ramakrishnan, Lalita

“…Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to…”
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B cells enhance early innate immune responses during bacterial sepsis by Kelly-Scumpia, Kindra M, Scumpia, Philip O, Weinstein, Jason S, Delano, Matthew J, Cuenca, Alex G, Nacionales, Dina C, Wynn, James L, Lee, Pui Y, Kumagai, Yutaro, Efron, Philip A, Akira, Shizuo, Wasserfall, Clive, Atkinson, Mark A, Moldawer, Lyle L

“…Microbes activate pattern recognition receptors to initiate adaptive immunity. T cells affect early innate inflammatory responses to viral infection, but both…”
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S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages by Realegeno, Susan, Kelly-Scumpia, Kindra M, Dang, Angeline Tilly, Lu, Jing, Teles, Rosane, Liu, Philip T, Schenk, Mirjam, Lee, Ernest Y, Schmidt, Nathan W, Wong, Gerard C L, Sarno, Euzenir N, Rea, Thomas H, Ochoa, Maria T, Pellegrini, Matteo, Modlin, Robert L

“…Triggering antimicrobial mechanisms in macrophages infected with intracellular pathogens, such as mycobacteria, is critical to host defense against the…”
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Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10 by Kelly-Scumpia, Kindra M, Scumpia, Philip O, Delano, Matthew J, Weinstein, Jason S, Cuenca, Alex G, Wynn, James L, Moldawer, Lyle L

“…Type I interferon (IFN) alpha/beta is critical for host defense. During endotoxicosis or highly lethal bacterial infections where systemic inflammation…”
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Type I Interferon Production by Tertiary Lymphoid Tissue Developing in Response to 2,6,10,14-Tetramethyl-Pentadecane (Pristane) by Nacionales, Dina C., Kelly, Kindra M., Lee, Pui Y., Zhuang, Haoyang, Li, Yi, Weinstein, Jason S., Sobel, Eric, Kuroda, Yoshiki, Akaogi, Jun, Satoh, Minoru, Reeves, Westley H.

“…Lymphoid neogenesis is associated with antibody-mediated autoimmune diseases such as Sjogren's syndrome and rheumatoid arthritis. Although systemic lupus…”
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Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling by Delano, Matthew J, Kelly-Scumpia, Kindra M, Thayer, Terri C, Winfield, Robert D, Scumpia, Philip O, Cuenca, Alex G, Harrington, Phillips B, O'Malley, Kerri A, Warner, Elizabeth, Gabrilovich, Sonia, Mathews, Clayton E, Laface, Drake, Heyworth, Paul G, Ramphal, Reuben, Strieter, Robert M, Moldawer, Lyle L, Efron, Philip A

“…Neutrophils are essential for successful host eradication of bacterial pathogens and for survival to polymicrobial sepsis. During inflammation, the bone marrow…”
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Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes by Scumpia, Philip O., Kelly, Kindra M., Reeves, Westley H., Stevens, Bruce R.

“…Astrocyte inflammation, reactive oxygen species (ROS) formation, and dysfunction form a common denominator shared by all the major neurodegenerative disorders…”
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Cecal ligation and puncture by Cuenca, Alex G, Delano, Matthew J, Kelly-Scumpia, Kindra M, Moldawer, Lyle L, Efron, Philip A

“…The cecum contains a high concentration of microbes, which are a combination of Gram-negative and Gram-positive flora. These bacteria range from anaerobic to…”
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Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling by Scumpia, Philip O, Kelly-Scumpia, Kindra M, Delano, Matthew J, Weinstein, Jason S, Cuenca, Alex G, Al-Quran, Samer, Bovio, Ian, Akira, Shizuo, Kumagai, Yutaro, Moldawer, Lyle L

“…Bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) can be activated by type I IFNs, TLR agonists, viruses, and bacteria to increase…”
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Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia by Cuenca, Alex G, Cuenca, Angela L, Winfield, Robert D, Joiner, Dallas N, Gentile, Lori, Delano, Matthew J, Kelly-Scumpia, Kindra M, Scumpia, Philip O, Matheny, Michael K, Scarpace, Philip J, Vila, Lizette, Efron, Philip A, LaFace, Drake M, Moldawer, Lyle L

“…Cancer progression is associated with inflammation, increased metabolic demand, infection, cachexia, and eventually death. Myeloid-derived suppressor cells…”
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Modulating the extracellular matrix to treat wound healing defects in Ehlers-Danlos syndrome by Kelly-Scumpia, Kindra M., Archang, Maani M., Purbey, Prabhat K., Yokota, Tomohiro, Wu, Rimao, McCourt, Jackie, Li, Shen, Crosbie, Rachelle H., Scumpia, Philip O., Deb, Arjun

“…Classic Ehlers-Danlos syndrome (cEDS) is a genetic disorder of the connective tissue that is characterized by mutations in genes coding type V collagen. Wound…”
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TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis by Cuenca, Alex G, Joiner, Dallas N, Gentile, Lori F, Cuenca, Angela L, Wynn, James L, Kelly-Scumpia, Kindra M, Scumpia, Philip O, Behrns, Kevin E, Efron, Philip A, Nacionales, Dina, Lui, Chao, Wallet, Shannon M, Reeves, Westley H, Mathews, Clayton E, Moldawer, Lyle L

“…Current evidence suggests that neonatal immunity is functionally distinct from adults. Although TLR signaling through the adaptor protein, MyD88, has been…”
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Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane by Barker, Tolga T, Lee, Pui Y, Kelly-Scumpia, Kindra M, Weinstein, Jason S, Nacionales, Dina C, Kumagai, Yutaro, Akira, Shizuo, Croker, Byron P, Sobel, Eric S, Reeves, Westley H, Satoh, Minoru

“…Diffuse alveolar hemorrhage is an uncommon, yet often fatal, complication of systemic lupus erythematosus (SLE). Advances in the treatment of alveolar…”
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Hypothermia induces anti-inflammatory cytokines and inhibits nitric oxide and myeloperoxidase-mediated damage in the hearts of endotoxemic rats by Scumpia, Philip O, Sarcia, Paul J, Kelly, Kindra M, DeMarco, Vincent G, Skimming, Jeffrey W

“…s: The impairment of cardiac contractility during endotoxemia involves induction of nitric oxide formation through a cascade of events initiated by…”
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ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-γ by Kelly-Scumpia, Kindra M., Choi, Aaron, Shirazi, Roksana, Bersabe, Hannah, Park, Esther, Scumpia, Philip O., Ochoa, Maria T., Yu, Jing, Ma, Feiyang, Pellegrini, Matteo, Modlin, Robert L.

“…Myeloid derived suppressor cells (MDSCs) are a population of immature myeloid cells that suppress adaptive immune function, yet the factors that regulate their…”
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B Cell Proliferation, Somatic Hypermutation, Class Switch Recombination, and Autoantibody Production in Ectopic Lymphoid Tissue in Murine Lupus by Nacionales, Dina C, Weinstein, Jason S, Yan, Xiao-Jie, Albesiano, Emilia, Lee, Pui Y, Kelly-Scumpia, Kindra M, Lyons, Robert, Satoh, Minoru, Chiorazzi, Nicholas, Reeves, Westley H

“…Intraperitoneal exposure of nonautoimmune mice to 2,6,10,14-tetramethylpentadecane (TMPD) causes lupus and the formation of ectopic lymphoid tissue. Although…”
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Critical Role for CXC Ligand 10/CXC Receptor 3 Signaling in the Murine Neonatal Response to Sepsis by Cuenca, Alex G, Wynn, James L, Kelly-Scumpia, Kindra M, Scumpia, Philip O, Vila, Lizette, Delano, Matthew J, Mathews, Clayton E, Wallet, Shannon M, Reeves, Westley H, Behrns, Kevin E, Nacionales, Dina C, Efron, Philip A, Kunkel, Steven L, Moldawer, Lyle L

“…Previous studies have suggested that neonates rely heavily on innate immunity for their antimicrobial response to bacterial infections. However, the innate…”
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