Search Results - "Kelly, Ciara M"

The management of metastatic GIST: current standard and investigational therapeutics by Kelly, Ciara M, Gutierrez Sainz, Laura, Chi, Ping

“…Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. The majority of GISTs harbor gain of function…”
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Moving beyond Karnofsky and ECOG Performance Status Assessments with New Technologies by Kelly, Ciara M., Shahrokni, Armin

“…Progress in cancer research is coupled with increased treatment complexity reliant upon accurate patient selection. Oncologists rely upon measurement…”
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Liver-directed therapy in metastatic colorectal cancer by Kelly, Ciara M., Kemeny, Nancy E.

“…Introduction: Colorectal cancer is a significant global health issue with over 1 million cases diagnosed annually throughout the world. 15% of patients…”
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The genomics and therapeutics of HER2-positive gastric cancer-from trastuzumab and beyond by Kelly, Ciara M, Janjigian, Yelena Y

“…Gastric cancer is a biologically heterogeneous tumor. The identification of human epidermal growth factor receptor-2 (HER2) biomarker overexpression in gastric…”
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Case Report: Response to Regional Melphalan via Limb Infusion and Systemic PD1 Blockade in Recurrent Myxofibrosarcoma: A Report of 2 Cases by Bartlett, Edmund K, D'Angelo, Sandra P, Kelly, Ciara M, Siegelbaum, Robert H, Fisher, Charles, Antonescu, Cristina R, Ariyan, Charlotte E

“…Treatment options for patients with advanced sarcoma remain limited. Promising responses to checkpoint inhibition have been observed, but responses to…”
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Clinical, genomic, and transcriptomic correlates of response to immune checkpoint blockade-based therapy in a cohort of patients with angiosarcoma treated at a single center by Rosenbaum, Evan, Antonescu, Cristina R, Smith, Shaleigh, Bradic, Martina, Kashani, Daniel, Richards, Allison L, Donoghue, Mark, Kelly, Ciara M, Nacev, Benjamin, Chan, Jason E, Chi, Ping, Dickson, Mark A, Keohan, Mary L, Gounder, Mrinal M, Movva, Sujana, Avutu, Viswatej, Thornton, Katherine, Zehir, Ahmet, Bowman, Anita S, Singer, Samuel, Tap, William, D’Angelo, Sandra

“…BackgroundAngiosarcoma is a histologically and molecularly heterogeneous vascular neoplasm with aggressive clinical behavior. Emerging data suggests that…”
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Proton radiotherapy for recurrent or metastatic sarcoma with palliative quad shot by Lee, Anna, Kang, Jung J., Bernstein, Havah, Marqueen, Kathryn E., Neal, Brian, Kelly, Ciara M., Dickson, Mark A., Jillian Tsai, Chiaojung, Tap, William, Singer, Samuel, Alektiar, Kaled, Lee, Nancy Y.

“…Patients with previously treated, recurrent or metastatic sarcomas who have progressed on multiples lines of systemic therapy may have limited options for…”
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Society for Immunotherapy of Cancer (SITC) recommendations on intratumoral immunotherapy clinical trials (IICT): from premalignant to metastatic disease by Luke, Jason J, Davar, Diwakar, Andtbacka, Robert H, Bhardwaj, Nina, Brody, Joshua D, Chesney, Jason, Coffin, Robert, de Baere, Thierry, de Gruijl, Tanja D, Fury, Matthew, Goldmacher, Gregory, Harrington, Kevin J, Kaufman, Howard, Kelly, Ciara M, Khilnani, Anuradha D, Liu, Ke, Loi, Sherene, Long, Georgina V, Melero, Ignacio, Middleton, Mark, Neyns, Bart, Pinato, David J, Sheth, Rahul A, Solomon, Stephen B, Szapary, Philippe, Marabelle, Aurelien

“…BackgroundIntratumorally delivered immunotherapies have the potential to favorably alter the local tumor microenvironment and may stimulate systemic host…”
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The relationship between leisure activities and psychological resources that support a sustainable career: The role of leisure seriousness and work-leisure similarity by Kelly, Ciara M., Strauss, Karoline, Arnold, John, Stride, Chris

“…While leisure plays an increasingly important role in individuals' lives, little is known about its potential to influence career sustainability. Drawing on…”
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HER2: An emerging target in colorectal cancer by Greally, Megan, Kelly, Ciara M., Cercek, Andrea

“…Despite advances in the treatment of metastatic colorectal cancer (CRC) the 5-year survival of patients with this disease remains low. A small proportion of…”
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Seeking an “i-deal” balance: Schedule-flexibility i-deals as mediating mechanisms between supervisor emotional support and employee work and home performance by Kelly, Ciara M., Rofcanin, Yasin, Las Heras, Mireia, Ogbonnaya, Chidiebere, Marescaux, Elise, Bosch, María José

“…Requests for flexible work practices have become commonplace, with the aim of helping employees perform more effectively in both their private and work lives…”
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The emerging role of immunotherapy for the treatment of sarcoma by Klemen, Nicholas D., Kelly, Ciara M., Bartlett, Edmund K.

“…Clinicians caring for patients with sarcoma founded the field of cancer immunotherapy. Despite this, contemporary success with immunotherapy for sarcoma has…”
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Management of pelvic sarcoma by Lee, Jay S., Kelly, Ciara M., Bartlett, Edmund K.

“…Pelvic sarcomas are a rare and heterogenous group of tumors divided into two groups: soft tissue sarcomas and bone sarcomas. Soft tissue sarcomas of the pelvis…”
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Objective Response Rate Among Patients With Locally Advanced or Metastatic Sarcoma Treated With Talimogene Laherparepvec in Combination With Pembrolizumab: A Phase 2 Clinical Trial by Kelly, Ciara M, Antonescu, Cristina R, Bowler, Timothy, Munhoz, Rodrigo, Chi, Ping, Dickson, Mark A, Gounder, Mrinal M, Keohan, Mary Louise, Movva, Sujana, Dholakia, Reena, Ahmad, Hamza, Biniakewitz, Matthew, Condy, Mercedes, Phelan, Haley, Callahan, Margaret, Wong, Phillip, Singer, Sam, Ariyan, Charlotte, Bartlett, Edmund K, Crago, Aimee, Yoon, Sam, Hwang, Sinchun, Erinjeri, Joseph P, Qin, Li-Xuan, Tap, William D, D'Angelo, Sandra P

“…Patients with advanced sarcoma have limited treatment options. Talimogene laherparepvec (T-VEC) has been shown to increase tumor-specific immune activation via…”
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A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma by Kelly, Ciara M, Qin, Li-Xuan, Whiting, Karissa A, Richards, Allison L, Avutu, Viswatej, Chan, Jason E, Chi, Ping, Dickson, Mark A, Gounder, Mrinal M, Keohan, Mary Louise, Movva, Sujana, Nacev, Benjamin A, Rosenbaum, Evan, Adamson, Travis, Singer, Samuel, Bartlett, Edmund K, Crago, Aimee M, Yoon, Sam S, Hwang, Sinchun, Erinjeri, Joseph P, Antonescu, Cristina R, Tap, William D, D'Angelo, Sandra P

“…Epacadostat, an indole 2,3 dioxygenase 1 (IDO1) inhibitor, proposed to shift the tumor microenvironment toward an immune-stimulated state, showed early promise…”
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Targeted therapy in older patients with solid tumors by Kelly, Ciara M, Power, Derek G, Lichtman, Stuart M

“…The introduction of targeted therapy has ushered in the era of personalized medicine in cancer therapy. The increased understanding of tumor heterogeneity has…”
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Sorafenib in Dupuytren and Ledderhose Disease by Schoenfeld, Joshua D, Agaram, Narasimhan P, Lefkowitz, Robert A, Kelly, Ciara M, Healey, John H, Gounder, Mrinal M

“…Palmar and plantar fibromatosis are benign proliferative processes which present as a diffuse thickening or nodules of the hands and/or feet and may lead to…”
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A Single-Arm Phase 2 Trial of Trametinib in Patients with Locally Advanced or Metastatic Epithelioid Hemangioendothelioma by Schuetze, Scott M, Ballman, Karla V, Heise, Rachel, Ganjoo, Kristen N, Davis, Elizabeth J, George, Suzanne, Burgess, Melissa A, Choy, Edwin, Shepard, Dale R, Tinoco, Gabriel, Hirbe, Angela, Kelly, Ciara M, Attia, Steven, Deshpande, Hari A, Schwartz, Gary K, Siontis, Brittany L, Riedel, Richard F, von Mehren, Margaret, Kozlowski, Erin, Chen, Helen X, Astbury, Caroline, Rubin, Brian P

“…Epithelioid hemangioendothelioma (EHE) is a rare vascular cancer with pathogenic TAZ-CAMTA1 (calmodulinbinding transcription activator 1) operating as an…”
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Histology-specific clinical trial of lenvatinib and pembrolizumab in patients with sarcoma by Movva, Sujana, Seier, Kenneth, Avutu, Viswatej, Banks, Lauren B, Chan, Jason, Chi, Ping, Dickson, Mark A, Gounder, Mrinal M, Kelly, Ciara M, Keohan, Mary L, Maki, Robert, Rosenbaum, Evan, Salcito, Tiffany, Rodriguez, Kaithleen, Dempsey, Rebecca, Meyers, Paul A, Cohen, Seth M, Hensley, Martee L, Konner, Jason A, Schram, Alison M, Lefkowitz, Robert A, Erinjeri, Joseph P, Qin, Li-Xuan, Tap, William D, D'Angelo, Sandra P

“…Survival of patients with metastatic sarcoma remains poor, and there is pressing need for new therapies. Most sarcoma subtypes are not responsive to immune…”
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Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma by Gleason, Caroline E, Dickson, Mark A, Klein Dooley, Mary E, Antonescu, Cristina R, Gularte-Mérida, Rodrigo, Benitez, Marimar, Delgado, Juliana I, Kataru, Raghu P, Tan, Mark Wei Yi, Bradic, Martina, Adamson, Travis E, Seier, Kenneth, Richards, Allison L, Palafox, Marta, Chan, Eric, D'Angelo, Sandra P, Gounder, Mrinal M, Keohan, Mary Louise, Kelly, Ciara M, Chi, Ping, Movva, Sujana, Landa, Jonathan, Crago, Aimee M, Donoghue, Mark T A, Qin, Li-Xuan, Serra, Violetta, Turkekul, Mesruh, Barlas, Afsar, Firester, Daniel M, Manova-Todorova, Katia, Mehrara, Babak J, Kovatcheva, Marta, Tan, Nguan Soon, Singer, Samuel, Tap, William D, Koff, Andrew

“…We conducted research on CDK4/6 inhibitors (CDK4/6i) simultaneously in the preclinical and clinical spaces to gain a deeper understanding of how senescence…”
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