Search Results - "Kellstein, D E"

Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study by Kellstein, D E, Lipton, R B, Geetha, R, Koronkiewicz, K, Evans, F T, Stewart, W F, Wilkes, K, Furey, S A, Subramanian, T, Cooper, S A

“…A total of 729 migraine sufferers with moderate to severe baseline pain evaluated a single 200, 400 or 600 mg dose of a new liquigel formulation of ibuprofen…”
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The Safety Profile of Nonprescription Ibuprofen in Multiple-Dose Use: A Meta-Analysis by Kellstein, David E., Waksman, Joel A., Furey, Sandy A., Binstok, Giselle, Cooper, Stephen A.

“…A meta‐analysis was performed to compare the incidence of adverse experiences (AEs) during the multiple‐dose use of nonprescription ibuprofen to a placebo…”
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New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 3. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents:  Variations at the 5 Position by Janusz, John M, Young, Patricia A, Ridgeway, James M, Scherz, Michael W, Enzweiler, Kevin, Wu, Laurence I, Gan, Lixian, Chen, Julian, Kellstein, David E, Green, Shelley A, Tulich, Jennifer L, Rosario-Jansen, Theresa, Magrisso, I. Jack, Wehmeyer, Kenneth R, Kuhlenbeck, Deborah L, Eichhold, Thomas H, Dobson, Roy L. M

“…We report an expansion of the scope of our initial discovery that 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs) are…”
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Effect of chronic treatment with tricyclic antidepressants upon antinociception induced by intrathecal injection of morphine and monoamines by Kellstein, D E, Malseed, R T, Ossipov, M H, Goldstein, F J

“…The effects of acute and chronic treatment with tricyclic antidepressants (TCA) upon antinociception induced by intrathecally administered serotonin (5-HT),…”
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Cholecystokinin and its antagonist lorglumide respectively attenuate and facilitate morphine-induced inhibition of C-fiber evoked discharges of dorsal horn nociceptive neurons by Kellstein, D E, Price, D D, Mayer, D J

“…Extracellular single unit recordings were made from dorsal horn nociceptive neurons of intact, urethane-anesthetized rats during controlled electrical…”
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New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 2. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents:  Variations of the Dihydrobenzofuran Ring by Janusz, John M, Young, Patricia A, Scherz, Michael W, Enzweiler, Kevin, Wu, Laurence I, Gan, Lixian, Pikul, Stanislaw, McDow-Dunham, Kelly L, Johnson, Carl R, Senanayake, C. B, Kellstein, David E, Green, Shelley A, Tulich, Julie L, Rosario-Jansen, Theresa, Magrisso, I. Jack, Wehmeyer, Kenneth R, Kuhlenbeck, Deborah L, Eichhold, Thomas H, Dobson, Roy L. M

“…A series of 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs) were found to be nonsteroidal antiinflammatory and analgesic agents…”
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Opioid-monoamine interactions in spinal antinociception: evidence for serotonin but not norepinephrine reciprocity by Kellstein, David E, Malseed, Roger T, Goldstein, Frederick J

“…Anatomical and electrophysiological studies have demonstrated that enkephalinergic, noradrenergic, and serotonergic pathways projecting from the brain-stem to…”
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New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 1. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents:  Discovery and Variation of the 5-Keto Substituent by Janusz, John M, Young, Patricia A, Ridgeway, James M, Scherz, Michael W, Enzweiler, Kevin, Wu, Laurence I, Gan, Lixian, Darolia, Renuka, Matthews, Randall S, Hennes, Duane, Kellstein, David E, Green, Shelley A, Tulich, Jennifer L, Rosario-Jansen, Theresa, Magrisso, I. Jack, Wehmeyer, Kenneth R, Kuhlenbeck, Deborah L, Eichhold, Thomas H, Dobson, Roy L. M, Sirko, Steven P, Farmer, Ralph W

“…A series of 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs) were prepared and evaluated as potential nonsteroidal…”
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Opioid inhibition of kainic acid-induced scratching: mediation by mu and sigma but not delta and kappa receptors by Kellstein, D E, Coghill, R C, Frenk, H, Bossut, D F, Mayer, D J

“…Scratching induced by intrathecal (IT) administration of kainic acid (0.5 nmol) to rats was inhibited by IT pretreatment with the selective mu agonists…”
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Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons by Kellstein, D E, Price, D D, Hayes, R L, Mayer, D J

“…Previous studies suggest that the undecapeptide substance P (SP) functions as a primary afferent neurotransmitter or neuromodulator of nociception which may…”
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Calcitonin gene-related peptide enhances substance P-induced behaviors via metabolic inhibition: in vivo evidence for a new mechanism of neuromodulation by Mao, J, Coghill, R C, Kellstein, D E, Frenk, H, Mayer, D J

“…The present study examined the effects of intrathecal (i.t.) injection of calcitonin gene-related peptide (CGRP) on caudally directed biting and scratching…”
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Cholecystokinin and opiate interactions by Mayer, D J, Kellstein, D E

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Chronic administration of cholecystokinin antagonists reverses the enhancement of spinal morphine analgesia induced by acute pretreatment by Kellstein, D E, Mayer, D J

“…The effects of acute and chronic (22 days) treatment with the cholecystokinin (CCK) antagonists proglumide and lorglumide on antinociception induced by…”
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Contrasting effects of acute vs. chronic tricyclic antidepressant treatment on central morphine analgesia by Kellstein, David E, Malseed, Roger T, Goldstein, Frederick J

“…Antinociception following central opioid microinjection in rats was assessed weekly via a tail-flick procedure during chronic tricyclic antidepressant (TCA)…”
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Spinal co-administration of cholecystokinin antagonists with morphine prevents the development of opioid tolerance by Kellstein, David E, Mayer, David J

“…The effects of intrathecal (i.t.) co-administration of the cholecystokinin (CCK) antagonists lorglumide or proglumide with a "low" (1 microgram) and "high" (10…”
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New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent by Janusz, J M, Young, P A, Ridgeway, J M, Scherz, M W, Enzweiler, K, Wu, L I, Gan, L, Darolia, R, Matthews, R S, Hennes, D, Kellstein, D E, Green, S A, Tulich, J L, Rosario-Jansen, T, Magrisso, I J, Wehmeyer, K R, Kuhlenbeck, D L, Eichhold, T H, Dobson, R L, Sirko, S P, Farmer, R W

“…A series of 5-keto-substituted 7-tert-buty1-2,3-dihydro-3,3- dimethylbenzofurans (DHDMBFs) were prepared and evaluated as potential nonsteroidal…”
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New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 2. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents:  Variations of the Dihydrobenzofuran Ring by Janusz, John M, Young, Patricia A, Scherz, Michael W, Enzweiler, Kevin, Wu, Laurence I, Gan, Lixian, Pikul, Stanislaw, McDow-Dunham, Kelly L, Johnson, Carl R, Senanayake, C. B, Kellstein, David E, Green, Shelley A, Tulich, Jennifer L, Rosario-Jansen, Theresa, Magrisso, I. Jack, Wehmeyer, Kenneth R, Kuhlenbeck, Deborah L, Eichhold, Thomas H, Dobson, Roy L. M

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