Search Results - "Kelliher, Jessica L"

The Two-Component System ArlRS and Alterations in Metabolism Enable Staphylococcus aureus to Resist Calprotectin-Induced Manganese Starvation by Radin, Jana N, Kelliher, Jessica L, Párraga Solórzano, Paola K, Kehl-Fie, Thomas E

“…During infection the host imposes manganese and zinc starvation on invading pathogens. Despite this, Staphylococcus aureus and other successful pathogens…”
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Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination by Kelliher, Jessica L., West, Kirk L., Gong, Qingguo, Leung, Justin W. C.

“…Histone ubiquitination plays an important role in the DNA damage response (DDR) pathway. RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15)…”
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Evolved histone tail regulates 53BP1 recruitment at damaged chromatin by Kelliher, Jessica L., Folkerts, Melissa L., Shen, Kaiyuan V., Song, Wan, Tengler, Kyle, Stiefel, Clara M., Lee, Seong-Ok, Dray, Eloise, Zhao, Weixing, Koss, Brian, Pannunzio, Nicholas R., Leung, Justin W.

“…The master DNA damage repair histone protein, H2AX, is essential for orchestrating the recruitment of downstream mediator and effector proteins at damaged…”
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PASTA kinase-dependent control of peptidoglycan synthesis via ReoM is required for cell wall stress responses, cytosolic survival, and virulence in Listeria monocytogenes by Kelliher, Jessica L, Grunenwald, Caroline M, Abrahams, Rhiannon R, Daanen, McKenzie E, Lew, Cassandra I, Rose, Warren E, Sauer, John-Demian

“…Pathogenic bacteria rely on protein phosphorylation to adapt quickly to stress, including that imposed by the host during infection. Penicillin-binding protein…”
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Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection by Radin, Jana N, Kelliher, Jessica L, Solórzano, Paola K Párraga, Grim, Kyle P, Ramezanifard, Rouhallah, Slauch, James M, Kehl-Fie, Thomas E

“…The ability of Staphylococcus aureus and other pathogens to consume glucose is critical during infection. However, glucose consumption increases the cellular…”
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PhoPR Contributes to Staphylococcus aureus Growth during Phosphate Starvation and Pathogenesis in an Environment-Specific Manner by Kelliher, Jessica L, Radin, Jana N, Kehl-Fie, Thomas E

“…Microbial pathogens must obtain all essential nutrients, including phosphate, from the host. To optimize phosphate acquisition in diverse and dynamic…”
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UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair by Lee, Seong-Ok, Kelliher, Jessica L., Song, Wan, Tengler, Kyle, Sarkar, Aradhan, Dray, Eloise, Leung, Justin W.C.

“…The ubiquitin signaling pathway is crucial for the DNA damage response pathway. More specifically, RNF168 is integral in regulating DNA repair proteins at…”
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The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity by Grim, Kyle P, San Francisco, Brian, Radin, Jana N, Brazel, Erin B, Kelliher, Jessica L, Párraga Solórzano, Paola K, Kim, Philip C, McDevitt, Christopher A, Kehl-Fie, Thomas E

“…During infection, the host sequesters essential nutrients, such as zinc, to combat invading microbes. Despite the ability of the immune effector protein…”
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LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation by West, Kirk L, Kelliher, Jessica L, Xu, Zhanzhan, An, Liwei, Reed, Megan R, Eoff, Robert L, Wang, Jiadong, Huen, Michael S Y, Leung, Justin W C

“…Abstract The tumor suppressor protein 53BP1 plays key roles in response to DNA double-strand breaks (DSBs) by serving as a master scaffold at the damaged…”
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Staphylococcus aureus Preferentially Liberates Inorganic Phosphate from Organophosphates in Environments where This Nutrient Is Limiting by Kelliher, Jessica L, Leder Macek, Aleeza J, Grudzinski, Kevin M, Radin, Jana N, Kehl-Fie, Thomas E

“…Phosphate is an essential nutrient that and other pathogens must acquire from the host during infection. While inorganic monophosphate (P ) is the preferred…”
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Acquisition of the Phosphate Transporter NptA Enhances Staphylococcus aureus Pathogenesis by Improving Phosphate Uptake in Divergent Environments by Kelliher, Jessica L, Radin, Jana N, Grim, Kyle P, Párraga Solórzano, Paola K, Degnan, Patrick H, Kehl-Fie, Thomas E

“…During infection, pathogens must obtain all inorganic nutrients, such as phosphate, from the host. Despite the essentiality of phosphate for all forms of life,…”
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Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity by Kelliher, Jessica L, Brazel, Erin B, Radin, Jana N, Joya, Eliot S, Párraga Solórzano, Paola K, Neville, Stephanie L, McDevitt, Christopher A, Kehl-Fie, Thomas E

“…To control infection, mammals actively withhold essential nutrients, including the transition metal manganese, by a process termed nutritional immunity. A…”
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1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response by Kelliher, Jessica L, Fil, Daniel, Hampton, Latambria, Rogers, Lora J, Shuttleworth, Sydnye L, Koss, Brian

“…BackgroundT cells are subjected to a variety of genotoxic events in the tumor microenvironment including replication stress, off-target toxicity of…”
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304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors by Shuttleworth, Sydnye L, Storey, Aaron J, Bauer, Michael A, Kelliher, Jessica L, Rogers, Lora J, Fil, Daniel, Edmondson, Rick D, Mackintosh, Sam G, Tackett, Alan J, Koss, Brian

“…BackgroundAdoptive T cell therapies are widely considered to be the next frontier in cancer immunotherapy treatment but are currently only effective at…”
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1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma by Hampton, Latambria, Rogers, Lora J, Bauer, Michael A, Fil, Daniel, Kelliher, Jessica L, Shuttleworth, Sydnye L, Darrigues, Emilie, Rodriguez, Analiz, Koss, Brian

“…BackgroundGlioblastoma (GBM) is the most common malignant brain tumor in adults and remains incurable.1 There is an urgent need to develop new therapeutic…”
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The Metallophore Staphylopine Enables italic toggle="yes">Staphylococcus aureus /italic> To Compete with the Host for Zinc and Overcome Nutritional Immunity by Kyle P. Grim, Brian San Francisco, Jana N. Radin, Erin B. Brazel, Jessica L. Kelliher, Paola K. Párraga Solórzano, Philip C. Kim, Christopher A. McDevitt, Thomas E. Kehl-Fie

“…ABSTRACT During infection, the host sequesters essential nutrients, such as zinc, to combat invading microbes. Despite the ability of the immune effector…”
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