Search Results - "Kellici, Tahsin F."

Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19 by Kellici, Tahsin F., Pilka, Ewa S., Bodkin, Michael J.

“…Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory…”
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Rational drug design and synthesis of molecules targeting the angiotensin II type 1 and type 2 receptors by Kellici, Tahsin F, Tzakos, Andreas G, Mavromoustakos, Thomas

“…The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an array of biological processes that regulate human health. Aberrant…”
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Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor by Kellici, Tahsin F, Ntountaniotis, Dimitrios, Kritsi, Eftichia, Zervou, Maria, Zoumpoulakis, Panagiotis, Potamitis, Constantinos, Durdagi, Serdar, Salmas, Ramin Ekhteiari, Ergun, Gizem, Gokdemir, Ebru, Halabalaki, Maria, Gerothanassis, Ioannis P, Liapakis, George, Tzakos, Andreas, Mavromoustakos, Thomas

“…The angiotensin II type 1 receptor (AT1R) has been recently crystallized. A new era has emerged for the structure-based rational drug design and the synthesis…”
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Small-molecule modulators of serine protease inhibitor proteins (serpins) by Kellici, Tahsin F., Pilka, Ewa S., Bodkin, Michael J.

“…•Targeting serpins with drug-like molecules remains a challenge in drug discovery.•Compounds targeting HSP47, antitrypsin, antithrombin, PAI-1 and neuroserpin…”
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Structure–function analysis of naturally occurring apolipoprotein A-I L144R, A164S and L178P mutants provides insight on their role on HDL levels and cardiovascular risk by Gkolfinopoulou, Christina, Soukou, Faye, Dafnis, Ioannis, Kellici, Tahsin F., Sanoudou, Despina, Mavromoustakos, Thomas, Stratikos, Efstratios, Chroni, Angeliki

“…Naturally occurring point mutations in apolipoprotein A-I (apoA-I), the major protein component of high-density lipoprotein (HDL), may affect plasma…”
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Mapping the interactions and bioactivity of quercetin⿿(2-hydroxypropyl)-β-cyclodextrin complex by Kellici, Tahsin F., Chatziathanasiadou, Maria V., Diamantis, Dimitris, Chatzikonstantinou, Alexandra V., Andreadelis, Ioannis, Christodoulou, Eirini, Valsami, Georgia, Mavromoustakos, Thomas, Tzakos, Andreas G.

“…[Display omitted] Natural products have served as a rich source for drug discovery and development. In the last decade their fruitful integration in the drug…”
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Crystal structure analysis, covalent docking, and molecular dynamics calculations reveal a conformational switch in PhaZ7 PHB depolymerase by Kellici, Tahsin F., Mavromoustakos, Thomas, Jendrossek, Dieter, Papageorgiou, Anastassios C.

“…ABSTRACT An open and a closed conformation of a surface loop in PhaZ7 extracellular poly(3‐hydroxybutyrate) depolymerase were identified in two high‐resolution…”
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The dynamic properties of angiotensin II type 1 receptor inverse agonists in solution and in the receptor site by Kellici, Tahsin F., Ntountaniotis, Dimitrios, Liapakis, George, Tzakos, Andreas G., Mavromoustakos, Thomas

“…In this article, the conformational properties of olmesartan and its methylated analogue were charted using a combination of NMR spectroscopy and molecular…”
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Rosemary tea consumption results to anxiolytic- and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; phytochemical investigation and in silico studies by Ferlemi, Anastasia-Varvara, Katsikoudi, Antigoni, Kontogianni, Vassiliki G., Kellici, Tahsin F., Iatrou, Grigoris, Lamari, Fotini N., Tzakos, Andreas G., Margarity, Marigoula

“…[Display omitted] •Rosemary tea is characterized by the presence of diterpenes, flavonoids and hydroxycinnamic derivatives.•Regular consumption of rosemary…”
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Pharmaceutical compositions for antihypertensive treatments: a patent review by Kellici, Tahsin F, Liapakis, George, Tzakos, Andreas G, Mavromoustakos, Thomas

“…New drug formulations against hypertension have a vital role in the quality of human life, as this risk factor for cardiovascular disease can be life…”
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Investigation of the Interactions of Silibinin with 2‑Hydroxypropyl-β-cyclodextrin through Biophysical Techniques and Computational Methods by Kellici, Tahsin F, Ntountaniotis, Dimitrios, Leonis, Georgios, Chatziathanasiadou, Maria, Chatzikonstantinou, Alexandra V, Becker-Baldus, Johanna, Glaubitz, Clemens, Tzakos, Andreas G, Viras, Kyriakos, Chatzigeorgiou, Petros, Tzimas, Stavros, Kefala, Evangelia, Valsami, Georgia, Archontaki, Helen, Papadopoulos, Manthos G, Mavromoustakos, Thomas

“…Cyclodextrins (CDs) are a well-known class of supermolecules that have been widely used to protect drugs against conjugation and metabolic inactivation as well…”
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Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: Rational design, synthesis, human plasma stability and in vitro evaluation by Stylos, Evgenios, Chatziathanasiadou, Maria V., Tsiailanis, Antonis, Kellici, Tahsin F., Tsoumani, Maria, Kostagianni, Androniki D., Deligianni, Maria, Tselepis, Alexandros D., Tzakos, Andreas G.

“…The current standard-of-care antiplatelet therapy in cardiovascular disease patients is consisted of cyclooxygenase-1 (COX-1) inhibitor aspirin, along with a…”
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Exploring the interactions of irbesartan and irbesartan–2-hydroxypropyl-β-cyclodextrin complex with model membranes by Liossi, Αdamantia S., Ntountaniotis, Dimitrios, Kellici, Tahsin F., Chatziathanasiadou, Maria V., Megariotis, Grigorios, Mania, Maria, Becker-Baldus, Johanna, Kriechbaum, Manfred, Krajnc, Andraž, Christodoulou, Eirini, Glaubitz, Clemens, Rappolt, Michael, Amenitsch, Heinz, Mali, Gregor, Theodorou, Doros N., Valsami, Georgia, Pitsikalis, Marinos, Iatrou, Hermis, Tzakos, Andreas G., Mavromoustakos, Thomas

“…The interactions of irbesartan (IRB) and irbesartan–2-hydroxypropyl-β-cyclodextrin (HP-β-CD) complex with dipalmitoyl phosphatidylcholine (DPPC) bilayers have…”
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PRESS: PRotEin S-Sulfenylation server by Sakka, Marianna, Tzortzis, Grigorios, Mantzaris, Michalis D, Bekas, Nick, Kellici, Tahsin F, Likas, Aristidis, Galaris, Dimitrios, Gerothanassis, Ioannis P, Tzakos, Andreas G

“…Transient S-sulfenylation of cysteine thiols mediated by reactive oxygen species plays a critical role in pathology, physiology and cell signaling. Therefore,…”
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Host–Guest Interactions between Candesartan and Its Prodrug Candesartan Cilexetil in Complex with 2‑Hydroxypropyl-β-cyclodextrin: On the Biological Potency for Angiotensin II Antagonism by Ntountaniotis, Dimitrios, Andreadelis, Ioannis, Kellici, Tahsin F, Karageorgos, Vlasios, Leonis, Georgios, Christodoulou, Eirini, Kiriakidi, Sofia, Becker-Baldus, Johanna, Stylos, Evgenios K, Chatziathanasiadou, Maria V, Chatzigiannis, Christos M, Damalas, Dimitrios E, Aksoydan, Busecan, Javornik, Uroš, Valsami, Georgia, Glaubitz, Clemens, Durdagi, Serdar, Thomaidis, Nikolaos S, Kolocouris, Antonios, Plavec, Janez, Tzakos, Andreas G, Liapakis, George, Mavromoustakos, Thomas

“…Renin–angiotensin aldosterone system inhibitors are for a long time extensively used for the treatment of cardiovascular and renal diseases. AT1 receptor…”
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Deconvoluting the Dual Antiplatelet Activity of a Plant Extract by Kontogianni, Vassiliki G, Tsoumani, Maria E, Kellici, Tahsin F, Mavromoustakos, Thomas, Gerothanassis, Ioannis P, Tselepis, Alexandros D, Tzakos, Andreas G

“…A thorough evaluation of the antiplatelet activity profile of hexane olive leaf extract in human platelets indicated a potent activity accomplished through a…”
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Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL by Kellici, Tahsin F, Chatziathanasiadou, Maria V, Lee, Min-Sung, Sayyad, Nisar, Geromichalou, Elena G, Vrettos, Eirinaios I, Tsiailanis, Antonis D, Chi, Seung-Wook, Geromichalos, George D, Mavromoustakos, Thomas, Tzakos, Andreas G

“…Anti-apoptotic proteins, like the Bcl-2 family proteins, present an important therapeutic cancer drug target. Their activity is orchestrated through…”
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Synthesis, Biology, Computational Studies and In Vitro Controlled Release of New Isoniazid-Based Adamantane Derivatives by Papageorgiou, Andria, Foscolos, Angeliki-Sofia, Papanastasiou, Ioannis P, Vlachou, Marilena, Siamidi, Angeliki, Vocat, Anthony, Cole, Stewart T, Kellici, Tahsin F, Mavromoustakos, Thomas, Tsotinis, Andrew

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Inclusion of Quercetin in Gold Nanoparticles Decorated with Supramolecular Hosts Amplifies Its Tumor Targeting Properties by Yilmaz, Mustafa, Karanastasis, Apostolos A, Chatziathanasiadou, Maria V, Oguz, Mehmet, Kougioumtzi, Anastasia, Clemente, Nausicaa, Kellici, Tahsin F, Zafeiropoulos, Nikolaos E, Avgeropoulos, Apostolos, Mavromoustakos, Thomas, Dianzani, Umberto, Karakurt, Serdar, Tzakos, Andreas G

“…Despite the anticancer potential of natural products (NPs), their limited bioavailability necessitates laborious derivatization or covalent conjugation to…”
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A combined NMR and molecular dynamics simulation study to determine the conformational properties of rat/mouse 35-55 myelin oligodendrocyte glycoprotein epitope implicated in the induction of experimental autoimmune encephalomyelitis by Ntountaniotis, Dimitrios, Vanioti, Μarianna, Kordopati, Golfo G., Kellici, Tahsin F., Marousis, Konstantinos D., Mavromoustakos, Thomas, Spyroulias, Georgios A., Golic Grdadolnik, Simona, Tselios, Theodore V.

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