Search Results - "Kelley, V. E."

Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury by Brennan, DC, Yui, MA, Wuthrich, RP, Kelley, VE

“…TNF and IL-1 are potent immunologic and inflammatory cytokines. We have previously reported increased levels of mRNA for TNF alpha and IL-1 beta in MRL-lpr…”
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Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis by Boswell, JM, Yui, MA, Burt, DW, Kelley, VE

“…Because TNF and IL-1 can initiate immunologic and inflammatory events alone or synergistically, a local increase in the levels of one or both of these…”
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Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis by Wuthrich, RP, Jevnikar, AM, Takei, F, Glimcher, LH, Kelley, VE

“…Intercellular adhesion molecule-1 (ICAM-1) is a cell-surface protein regulating interactions among immune cells. To determine whether altered expression of…”
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The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells by Endres, S, Ghorbani, R, Kelley, V E, Georgilis, K, Lonnemann, G, van der Meer, J W, Cannon, J G, Rogers, T S, Klempner, M S, Weber, P C

“…We examined whether the synthesis of interleukin-1 or tumor necrosis factor, two cytokines with potent inflammatory activities, is influenced by dietary…”
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Induction of various autoantibodies by mutant gene lpr in several strains of mice by Izui, S, Kelley, VE, Masuda, K, Yoshida, H, Roths, JB, Murphy, ED

“…The effect of the autosomal mutant gene lpr (lymphoproliferation) on the development of various autoantibodies and immune complex (IC) glomerulonephritis was…”
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Increased renal thromboxane production in murine lupus nephritis by KELLEY, V. E, SNEVE, S, MUSINSKI, S

“…To determine whether the amount of cyclooxygenase metabolites correlates with the development of lupus nephritis, intrarenal eicosanoid production was measured…”
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A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr mice by Kelley, VE, Ferretti, A, Izui, S, Strom, TB

“…Dietary supplementation of fish oil as the exclusive source of lipid suppresses autoimmune lupus in MRL-lpr mice. This marine oil diet decreases the lymphoid…”
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MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells by Wuthrich, Rudolf P., Glimcher, Laurie H., Yui, Mary A., Jevnikar, Anthony M., Dumas, Stephanie E., Kelley, Vicki E.

“…MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Proximal tubular (PT) epithelial cells express MHC class II…”
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Novel and enhanced IL-1 gene expression in autoimmune mice with lupus by Boswell, JM, Yui, MA, Endres, S, Burt, DW, Kelley, VE

“…IL-1 is a pleiotropic factor encoded for by at least two genes, alpha and beta, and capable of eliciting a broad set of immunologic and inflammatory events…”
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Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis by Kelley, VE, Gaulton, GN, Hattori, M, Ikegami, H, Eisenbarth, G, Strom, TB

“…In order to assess the importance of interleukin 2 receptor (IL-2R)-positive activated lymphocytes and macrophages in the pathogenesis of autoimmunity, we…”
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Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis by Wuthrich, RP, Yui, MA, Mazoujian, G, Nabavi, N, Glimcher, LH, Kelley, VE

“…Enhanced MHC class II (Ia) antigen expression is a common feature of autoimmunity. The authors investigated the occurrence of renal Ia expression in…”
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Prostaglandin E2 inhibits oxygen consumption in rabbit medullary thick ascending limb by Lear, S, Silva, P, Kelley, V E, Epstein, F H

“…The effect of prostaglandin (PG) E2 on transport-dependent oxygen consumption (QO2) of rabbit medullary thick ascending limb (MTAL) cells was studied…”
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Roles for thromboxane A2 and leukotrienes in endotoxin–induced acute renal failure by Badr, Kamal F., Kelley, Vicki E., Rennke, Helmut G., Brenner, Barry M.

“…Roles for thromboxane A2 and leukotrienes in endotoxin–induced acute renal failure. Bolus i.v. administration of 100 µg/kg of E. Coli lipopoly-saccharide…”
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Cloned human interferon-gamma, but not interferon-beta or -alpha, induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines by Kelley, VE, Fiers, W, Strom, TB

“…The antigen presenting function of macrophages and other accessory cells requires the cell surface expression of class II major histocompatibility antigens,…”
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Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice by KIRKMAN, R. L, BARRETT, L. V, GAULTON, G. N, KELLEY, V. E, YTHIER, A, STROM, T. B

“…Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in…”
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Interleukin 2-diphtheria Toxin Fusion Protein Can Abolish Cell-Mediated Immunity in vivo by Kelley, V. E., Bacha, P., Pankewycz, O., Nichols, Jean C., Murphy, J. R., Strom, T. B.

“…De novo expression of the interleukin 2 receptor (IL-2R) is a critical and pivotal event in initiation of an immune response. Targeting the low-affinity…”
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Decreased expression of human class II antigens on monocytes from patients with acquired immune deficiency syndrome: increased expression with interferon-γ by HEAGY, W, KELLEY, V. E, STROM, T. B, MAYER, K, SHAPIRO, H. M, MANDEL, R, FINBERG, R

“…The expression of HLA-DR (a class II histocompatibility antigen) on monocytes isolated from the peripheral blood of normal individuals and patients with…”
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Increased macrophage colony-stimulating factor in neonatal and adult autoimmune MRL-lpr mice by Yui, MA, Brissette, WH, Brennan, DC, Wuthrich, RP, Rubin-Kelley, VE

“…Abnormal macrophages in MRL-lpr mice are implicated in the pathogenesis of autoimmune disease. These mice die of lupus nephritis by 5 to 6 months of age. This…”
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Inhibitory effects of anti-interleukin 2 receptor and anti-L3T4 antibodies on delayed type hypersensitivity: the role of complement and epitope by Kelley, VE, Gaulton, GN, Strom, TB

“…Although it is often assumed that anti-T cell antibodies mediate immunosuppression by targeting T cells for destruction, other activities should be considered…”
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Modification of experimental nephrotoxicity with fish oil as the vehicle for cyclosporine by Elzinga, L, Kelley, V E, Houghton, D C, Bennett, W M

“…Cyclosporine-associated renal dysfunction is well recognized. While renal vasoconstriction appears to be a major pathogenic factor, the precise mechanism…”
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