Search Results - "Kelley, Laura C"

Traversing the basement membrane in vivo: a diversity of strategies by Kelley, Laura C, Lohmer, Lauren L, Hagedorn, Elliott J, Sherwood, David R

“…The basement membrane is a dense, highly cross-linked, sheet-like extracellular matrix that underlies all epithelia and endothelia in multicellular animals…”
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Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression by Matus, David Q., Lohmer, Lauren L., Kelley, Laura C., Schindler, Adam J., Kohrman, Abraham Q., Barkoulas, Michalis, Zhang, Wan, Chi, Qiuyi, Sherwood, David R.

“…Despite critical roles in development and cancer, the mechanisms that specify invasive cellular behavior are poorly understood. Through a screen of…”
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Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence by Kelley, Laura C, Hayes, Karen E, Ammer, Amanda Gatesman, Martin, Karen H, Weed, Scott A

“…Tumor cell motility and invasion is governed by dynamic regulation of the cortical actin cytoskeleton. The actin-binding protein cortactin is commonly…”
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ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo by Hagedorn, Elliott J, Kelley, Laura C, Naegeli, Kaleb M, Wang, Zheng, Chi, Qiuyi, Sherwood, David R

“…Invadopodia are protrusive, F-actin-driven membrane structures that are thought to mediate basement membrane transmigration during development and tumor…”
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Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation by Kelley, Laura C, Weed, Scott A

“…Epidermal growth factor receptor (EGFR) internalization following ligand binding controls EGFR downstream pathway signaling activity. Internalized EGFR is…”
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Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation by Kelley, Laura C, Ammer, Amanda Gatesman, Hayes, Karen E, Martin, Karen H, Machida, Kazuya, Jia, Lin, Mayer, Bruce J, Weed, Scott A

“…The proto-oncogene Src tyrosine kinase (Src) is overexpressed in human cancers and is currently a target of anti-invasive therapies. Activation of Src is an…”
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NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner by Kozyreva, Varvara K, McLaughlin, Sarah L, Livengood, Ryan H, Calkins, Robin A, Kelley, Laura C, Rajulapati, Anuradha, Ice, Ryan J, Smolkin, Matthew B, Weed, Scott A, Pugacheva, Elena N

“…The prometastatic protein NEDD9 (neural precursor cell expressed, developmentally downregulated 9) is highly expressed in many cancers and is required for…”
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Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding by Keeley, Daniel P., Hastie, Eric, Jayadev, Ranjay, Kelley, Laura C., Chi, Qiuyi, Payne, Sara G., Jeger, Jonathan L., Hoffman, Brenton D., Sherwood, David R.

“…Basement membranes (BMs) are supramolecular matrices built on laminin and type IV collagen networks that provide structural and signaling support to tissues…”
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α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes by Jayadev, Ranjay, Chi, Qiuyi, Keeley, Daniel P, Hastie, Eric L, Kelley, Laura C, Sherwood, David R

“…Basement membranes (BMs) are cell-associated extracellular matrices that support tissue integrity, signaling, and barrier properties. Type IV collagen is…”
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Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs by Kelley, Laura C., Chi, Qiuyi, Cáceres, Rodrigo, Hastie, Eric, Schindler, Adam J., Jiang, Yue, Matus, David Q., Plastino, Julie, Sherwood, David R.

“…Matrix metalloproteinases (MMPs) are associated with decreased patient prognosis but have failed as anti-invasive drug targets despite promoting cancer cell…”
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Localized glucose import, glycolytic processing, and mitochondria generate a focused ATP burst to power basement-membrane invasion by Garde, Aastha, Kenny, Isabel W., Kelley, Laura C., Chi, Qiuyi, Mutlu, Ayse Sena, Wang, Meng C., Sherwood, David R.

“…Invasive cells use transient, energy-consuming protrusions to breach basement membrane (BM) barriers. Using the ATP sensor PercevalHR during anchor cell (AC)…”
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Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain by Naegeli, Kaleb M., Hastie, Eric, Garde, Aastha, Wang, Zheng, Keeley, Daniel P., Gordon, Kacy L., Pani, Ariel M., Kelley, Laura C., Morrissey, Meghan A., Chi, Qiuyi, Goldstein, Bob, Sherwood, David R.

“…Invasive cells use small invadopodia to breach basement membrane (BM), a dense matrix that encases tissues. Following the breach, a large protrusion forms to…”
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Forces drive basement membrane invasion in Caenorhabditis elegans by Cáceres, Rodrigo, Bojanala, Nagagireesh, Kelley, Laura C., Dreier, Jes, Manzi, John, Di Federico, Fahima, Chi, Qiuyi, Risler, Thomas, Testa, Ilaria, Sherwood, David R., Plastino, Julie

“…During invasion, cells breach basement membrane (BM) barriers with actin-rich protrusions. It remains unclear, however, whether actin polymerization applies…”
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The Caenorhabditis elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane by Costa, Daniel S, Kenny-Ganzert, Isabel W, Chi, Qiuyi, Park, Kieop, Kelley, Laura C, Garde, Aastha, Matus, David Q, Park, Junhyun, Yogev, Shaul, Goldstein, Bob, Gibney, Theresa V, Pani, Ariel M, Sherwood, David R

“…Cell invasion through basement membrane (BM) barriers is important in development, immune function and cancer progression. As invasion through BM is often…”
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Revisiting the ERK/Src cortactin switch by Kelley, Laura C., Hayes, Karen E., Gatesman Ammer, Amanda, Martin, Karen H., Weed, Scott A.

“…The filamentous (F)-actin regulatory protein cortactin plays an important role in tumor cell movement and invasion by promoting and stabilizing actin related…”
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Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans by Kelley, Laura C, Wang, Zheng, Hagedorn, Elliott J, Wang, Lin, Shen, Wanqing, Lei, Shijun, Johnson, Sam A, Sherwood, David R

“…This protocol describes how to use multichannel time-lapse confocal imaging of anchor-cell invasion in live Caenorhabditis elegans to monitor cell invasion…”
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Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior by Jones, Brandon C, Kelley, Laura C, Loskutov, Yuriy V, Marinak, Kristina M, Kozyreva, Varvara K, Smolkin, Matthew B, Pugacheva, Elena N

“…Commonly upregulated in human cancers, the scaffolding protein NEDD9/HEF1 is a known regulator of mesenchymal migration and cancer cell plasticity. However,…”
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Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification by ROTHSCHILD, Brian L, SHIM, Ann H, RABEN, David, WEED, Scott A, AMMER, Amanda Gatesman, KELLEY, Laura C, IRBY, Kimberly B, HEAD, Julie A, LIN CHEN, VARELLA-GARCIA, Marileila, SACKS, Peter G, FREDERICK, Barbara

“…Carcinoma cell motility and invasion are prerequisites for tumor cell metastasis, which requires regulation of the actin cytoskeleton. Cortactin is an…”
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Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer by Kelley, Laura C., Shahab, Sohrab, Weed, Scott A.

“…Coordinated regulation of the actin cytoskeleton is central to cell motility, invasion and metastasis. Head and neck squamous cell carcinoma (HNSCC) is a…”
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Invadopodia and basement membrane invasion in vivo by Lohmer, Lauren L, Kelley, Laura C, Hagedorn, Elliott J, Sherwood, David R

“…Over 20 years ago, protrusive, F-actin-based membrane structures, termed invadopodia, were identified in highly metastatic cancer cell lines. Invadopodia…”
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