Search Results - "Kelley, Kevin A"

Generation, characterization, and use of EKLF(Klf1)/CRE knock-in mice for cell-restricted analyses by Xue, Li, Mukherjee, Kaustav, Kelley, Kevin A, Bieker, James J

“…EKLF/Klf1 is a tissue-restricted transcription factor that plays a critical role in all aspects of erythropoiesis. Of particular note is its tissue-restricted…”
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Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis by Sahu, Bhavani S., Razzoli, Maria, McGonigle, Seth, Pallais, Jean Pierre, Nguyen, Megin E., Sadahiro, Masato, Jiang, Cheng, Lin, Wei-Jye, Kelley, Kevin A., Rodriguez, Pedro, Mansk, Rachel, Cero, Cheryl, Caviola, Giada, Palanza, Paola, Rao, Loredana, Beetch, Megan, Alejandro, Emilyn, Sham, Yuk Y., Frontini, Andrea, Salton, Stephen R., Bartolomucci, Alessandro

“…Pro-peptide precursors are processed into biologically active peptide hormones or neurotransmitters, each playing an essential role in physiology and disease…”
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Thyroid hormone-regulated chromatin landscape and transcriptional sensitivity of the pituitary gland by Cho, Young-Wook, Fu, Yulong, Huang, Chen-Che Jeff, Wu, Xuefeng, Ng, Lily, Kelley, Kevin A., Vella, Kristen R., Berg, Anders H., Hollenberg, Anthony N., Liu, Hong, Forrest, Douglas

“…Thyroid hormone (3,5,3’-triiodothyronine, T3) is a key regulator of pituitary gland function. The response to T3 is thought to hinge crucially on interactions…”
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Transport of mouse lines by shipment of live embryos by Kelley, Kevin A

“…Advances in techniques for the genetic manipulation of the laboratory mouse have resulted in a vast array of novel mouse lines for research. One challenge…”
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Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function by Liu, Hong, Lu, Ailing, Kelley, Kevin A, Forrest, Douglas

“…Abstract The function of a hormone receptor requires mechanisms to control precisely where, when, and at what level the receptor gene is expressed. An…”
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Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice by MIZUNO, Tooru M, KELLEY, Kevin A, PASINETTI, Giulio M, ROBERTS, James L, MOBBS, Charles V

“…Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese…”
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Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2 by Kelley, Kevin A., Ho, Lap, Winger, David, Freire-Moar, Jose, Borelli, Cy Blanco, Aisen, Paul S., Pasinetti, Giulio Maria

“…In this study we describe the generation of a transgenic mouse model with neuronal overexpression of the human cyclooxygenase-2, h(COX)-2, to explore its role…”
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Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice by Bongers, Gerold, Pacer, Michelle E, Geraldino, Thais H, Chen, Lili, He, Zhengxiang, Hashimoto, Daigo, Furtado, Glaucia C, Ochando, Jordi, Kelley, Kevin A, Clemente, Jose C, Merad, Miriam, van Bakel, Harm, Lira, Sergio A

“…The preferential localization of some neoplasms, such as serrated polyps (SPs), in specific areas of the intestine suggests that nongenetic factors may be…”
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Protein Tyrosine Phosphatase PTPN14 Is a Regulator of Lymphatic Function and Choanal Development in Humans by Au, Audrey C., Hernandez, Paolo A., Lieber, Ernest, Nadroo, Ali M., Shen, Yu-Ming, Kelley, Kevin A., Gelb, Bruce D., Diaz, George A.

“…The lymphatic vasculature is essential for the recirculation of extracellular fluid, fat absorption, and immune function and as a route of tumor metastasis…”
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Role of VGF-Derived Carboxy-Terminal Peptides in Energy Balance and Reproduction: Analysis of “Humanized” Knockin Mice Expressing Full-Length or Truncated VGF by Sadahiro, Masato, Erickson, Connor, Lin, Wei-Jye, Shin, Andrew C, Razzoli, Maria, Jiang, Cheng, Fargali, Samira, Gurney, Allison, Kelley, Kevin A, Buettner, Christoph, Bartolomucci, Alessandro, Salton, Stephen R

“…Targeted deletion of VGF, a secreted neuronal and endocrine peptide precursor, produces lean, hypermetabolic, and infertile mice that are resistant to diet-,…”
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Enhancement of IVF in the mouse by zona-drilling by Kelley, Kevin A

“…Cryopreservation of mouse sperm has become an essential method for the long-term storage of novel, genetically modified mouse lines. Cryopreserved sperm from…”
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The Evolution of Lipophilin Genes from Invertebrates to Tetrapods: DM-20 Cannot Replace Proteolipid Protein in CNS Myelin by Stecca, Barbara, Southwood, Cherie M, Gragerov, Alexander, Kelley, Kevin A, Friedrich, Victor L., Jr, Gow, Alexander

“…The proteolipid protein (PLP) gene encodes two myelin-specific protein isoforms, DM-20 and PLP, which are members of the highly conserved lipophilin family of…”
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Gcm1 expression defines three stages of chorio-allantoic interaction during placental development by Stecca, Barbara, Nait-Oumesmar, Brahim, Kelley, Kevin A., Voss, Anne K., Thomas, Tim, Lazzarini, Robert A.

“…The formation of the labyrinth layer is a critical step of placental development. The transcription factor glial cells missing 1 ( Gcm1) plays a pivotal role…”
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Targeted Deletion of the Vgf Gene Indicates that the Encoded Secretory Peptide Precursor Plays a Novel Role in the Regulation of Energy Balance by Hahm, Seung, Mizuno, Tooru M., Wu, T.John, Wisor, Jonathan P., Priest, Catherine A., Kozak, Christine A., Boozer, Carol N., Peng, Bonnie, McEvoy, Robert C., Good, Paul, Kelley, Kevin A., Takahashi, Joseph S., Pintar, John E., Roberts, James L., Mobbs, Charles V., Salton, Stephen R.J.

“…To determine the function of VGF, a secreted polypeptide that is synthesized by neurons, is abundant in the hypothalamus, and is regulated in the brain by…”
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REARRANGEMENT OF GENES LOCATED ON HOMOLOGOUS CHROMOSOMAL SEGMENTS IN MOUSE AND MAN: THE LOCATION OF GENES FOR ALPHA-AND BETA-INTERFERON, ALPHA-1 ACID GLYCOPROTEIN-1 AND -2, AND AMINOLEVULINATE DEHYDRATASE ON MOUSE CHROMOSOME 4 by Nadeau, Joseph H, Berger, Franklin G, Kelley, Kevin A, Pitha, Paula M, Sidman, Charles L, Worrall, Neil

“…Gene mapping studies to determine the order of alpha- and beta-interferon (Ifa, Ifb), aminolevulinate dehydratase (Lv), and alpha-1 acid glycoprotein-1 and -2…”
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Paradoxical Locomotor Behavior of Dopamine D1 Receptor Transgenic Mice by Dracheva, Stella, Xu, Ming, Kelley, Kevin A., Haroutunian, Vahram, Holstein, Gay R., Haun, Shannan, Silverstein, Jeffrey H., Sealfon, Stuart C.

“…The behavioral effects of augmenting dopamine D1 receptor expression in the brain were investigated in mice incorporating additional copies of the mouse D1…”
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Renal cyst formation and multifocal neoplasia in transgenic mice carrying the simian virus 40 early region by Kelley, K A, Agarwal, N, Reeders, S, Herrup, K

“…Simian virus 40 early region transgenic mice develop characteristic pathological abnormalities of the brain, kidney, and thymus, due to expression of large-T…”
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Expression and chromosome localization of the murine cystic fibrosis transmembrane conductance regulator by Kelley, K A, Stamm, S, Kozak, C A

“…A 13.5-kb genomic fragment of the mouse cystic fibrosis transmembrane conductance regulator (CFTR) gene was isolated from a C57BL/6J liver DNA library, using a…”
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Expression of Thy-1/lacZ fusion genes in the CNS of transgenic mice by Kelley, K A, Friedrich, Jr, V L, Sonshine, A, Hu, Y, Lax, J, Li, J, Drinkwater, D, Dressler, H, Herrup, K

“…Thy-1 is a cell surface glycoprotein of unknown function that is found on nerve cells and mature T-lymphocytes. To study the regulation of Thy-1 gene…”
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