Search Results - "Kelley, KW"

Growth hormone, lymphocytes and macrophages by Kelley, K W

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Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma by Wen, Haijun, Ma, Huajuan, Cai, Qichun, Lin, Suxia, Lei, Xinxing, He, Bin, Wu, Sijin, Wang, Zifeng, Gao, Yan, Liu, Wensheng, Liu, Weiping, Tao, Qian, Long, Zijie, Yan, Min, Li, Dali, Kelley, Keith W., Yang, Yongliang, Huang, Huiqiang, Liu, Quentin

“…A recurrent ECSIT mutation in individuals with extranodal natural killer/T cell lymphoma induces NFκB in cancer cells, leading to macrophage activation, and…”
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Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system by Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., Johnson, R. W.

“…ABSTRACTAcute cognitive impairment (i.e., delirium) is common in elderly emergency department patients and frequently results from infections that are…”
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Cytokine-induced sickness behavior by Kelley, Keith W., Bluthé, Rose-Marie, Dantzer, Robert, Zhou, Jian-Hua, Shen, Wen-Hong, Johnson, Rodney W., Broussard, Suzanne R.

“…The behavioral repertoire of humans and animals changes dramatically following infection. Sick individuals have little motivation to eat, are listless,…”
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Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System by GODBOUT, Jonathan P, MOREAU, Maïté, LESTAGE, Jacques, JING CHEN, SPARKMAN, Nathan L, O'CONNOR, Jason, CASTANON, Nathalie, KELLEY, Keith W, DANTZER, Robert, JOHNSON, Rodney W

“…Exposure to peripheral infections may be permissive to cognitive and behavioral complications in the elderly. We have reported that peripheral stimulation of…”
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Review of metformin and glyburide in the management of gestational diabetes by Carroll DG, Kelley KW

“…Background: Worldwide, gestational diabetes affects 15% of pregnancies. It is recommended in patients with gestational diabetes to initiate diet therapy and if…”
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Bacille Calmette-Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3-Dioxygenase in Mice by Moreau, Maïté, Lestage, Jacques, Verrier, Danièle, Mormède, Cécile, Kelley, Keith W., Dantzer, Robert, Castanon, Nathalie

“…BackgroundActivation of the indoleamine 2,3-dioxygenase (IDO) enzyme and the resulting decrease in plasma tryptophan (TRP) levels appears to be a crucial link…”
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A new concept in neurodegeneration: TNFα is a silencer of survival signals by Venters, Homer D., Dantzer, Robert, Kelley, Keith W.

“…The p55 receptor for the pro-inflammatory cytokine tumor necrosis factor α (TNFα) is best characterized by its ability to induce signals that trigger cell…”
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Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent? by Dantzer, Robert, Konsman, Jan-Pieter, Bluthé, Rose-Marie, Kelley, Keith W

“…The first studies carried out on the mechanisms by which peripheral immune stimuli signal the brain to induce fever, activation of the…”
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IL-1β Impairs Insulin-Like Growth Factor I-Induced Differentiation and Downstream Activation Signals of the Insulin-Like Growth Factor I Receptor in Myoblasts by Broussard, Suzanne R., McCusker, Robert H., Novakofski, Jan E., Strle, Klemen, Shen, Wen Hong, Johnson, Rodney W., Dantzer, Robert, Kelley, Keith W.

“…Abstract Proinflammatory cytokines are elevated in disorders characterized by muscle wasting and weakness, such as inflammatory myopathies and AIDS wasting. We…”
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Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior by Parnet, Patricia, Kelley, Keith W., Bluthé, Rose-Marie, Dantzer, Robert

“…Sickness behavior refers to the coordinated set of behavior changes that develop in sick individuals during the course of an infection. At the molecular level,…”
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IL-1β-Mediated Innate Immunity Is Amplified in the db/db Mouse Model of Type 2 Diabetes by O’Connor, Jason C., Satpathy, Ansuman, Hartman, Matthew E., Horvath, Emily M., Kelley, Keith W., Dantzer, Robert, Johnson, Rodney W., Freund, Gregory G.

“…Abstract Chronic inflammation appears to play a critical role in type 2 diabetes and its complications. Here we tested the hypothesis that this inflammatory…”
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Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in mice by Bluthé, Rose-Marie, Kelley, Keith W., Dantzer, Robert

“…Central administration of insulin-like growth factor-I (IGF-I) attenuates sickness behavior in response to the cytokine inducer lipopolysaccharide. The present…”
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Interleukin-10 in the brain by Strle, K, Zhou, J H, Shen, W H, Broussard, S R, Johnson, R W, Freund, G G, Dantzer, R, Kelley, K W

“…Interleukin (IL)-10 is synthesized in the central nervous system (CNS) and acts to limit clinical symptoms of stroke, multiple sclerosis, Alzheimer's disease,…”
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Proinflammatory Cytokine Impairment of Insulin-Like Growth Factor I-Induced Protein Synthesis in Skeletal Muscle Myoblasts Requires Ceramide by Strle, Klemen, Broussard, Suzanne R, McCusker, Robert H, Shen, Wen-Hong, Johnson, Rodney W, Freund, Gregory G, Dantzer, Robert, Kelley, Keith W

“…GH and IGF-I control over 80% of postnatal growth. We recently established that TNFα impairs the ability of IGF-I to increase protein synthesis and promote…”
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α-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain by Godbout, Jonathan P, Berg, Brian M, Kelley, Keith W, Johnson, Rodney W

“…The purpose of this study was to determine if α-tocopherol—a reactive oxygen species (ROS) scavenging agent—inhibits LPS-induced oxidative stress and…”
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From hormones to immunity: the physiology of immunology by Kelley, Keith W

“…Discoveries in the physiology of immunology have increased at an increasing rate during the past two decades. It is now recognized that the immune system is…”
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Molecular Basis of Sickness Behavior by DANTZER, ROBERT, BLUTHÉ, ROSE-MARIE, GHEUSI, GILLES, CREMONA, SANDRINE, LAYÉ, SOPHIE, PARNET, PATRICIA, KELLEY, KEITH W.

“…Peripheral and central injections of lipopolysaccharide (LPS), a cytokine inducer, and recombinant proinflammatory cytokines such as interleukin-1 beta (IL-1…”
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Cytokine-Hormone Interactions: Tumor Necrosis Factor α Impairs Biologic Activity and Downstream Activation Signals of the Insulin-Like Growth Factor I Receptor in Myoblasts by Broussard, Suzanne R, MCCusker, Robert H, Novakofski, Jan E, Strle, Klemen, Hong Shen, Wen, Johnson, Rodney W, Freund, Gregory G, Dantzer, Robert, Kelley, Keith W

“…TNFα is elevated following damage to skeletal muscle. Here we provide evidence that TNFα acts on muscle cells to induce a state of IGF-I receptor resistance…”
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A New Mechanism of Neurodegeneration: A Proinflammatory Cytokine Inhibits Receptor Signaling by a Survival Peptide by Venters, Homer D., Tang, Qingsong, Liu, Qiang, VanHoy, Roger W., Dantzer, Robert, Kelley, Keith W.

“…Heightened expression of both a proinflammatory cytokine, tumor necrosis factor α (TNF-α), and a survival peptide, insulin-like growth factor I (IGF-I), occurs…”
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