Search Results - "Kelley, Brian"

Developing therapeutic monoclonal antibodies at pandemic pace by Kelley, Brian

“…The time from discovery to proof-of-concept trials could be reduced to 5–6 months from a traditional timeline of 10–12 months…”
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Industrialization of mAb production technology: The bioprocessing industry at a crossroads by Kelley, Brian

“…Manufacturing processes for therapeutic monoclonal antibodies (mAbs) have evolved tremendously since the first licensed mAb product (OKT3) in 1986. The rapid…”
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The history and potential future of monoclonal antibody therapeutics development and manufacturing in four eras by Kelley, Brian

“…Therapeutic monoclonal antibody (mAb) development and the processes for manufacturing drug substance have evolved since the first approval of the mAb in 1986…”
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Analyzing Learned Molecular Representations for Property Prediction by Yang, Kevin, Swanson, Kyle, Jin, Wengong, Coley, Connor, Eiden, Philipp, Gao, Hua, Guzman-Perez, Angel, Hopper, Timothy, Kelley, Brian, Mathea, Miriam, Palmer, Andrew, Settels, Volker, Jaakkola, Tommi, Jensen, Klavs, Barzilay, Regina

“…Advancements in neural machinery have led to a wide range of algorithmic solutions for molecular property prediction. Two classes of models in particular have…”
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Marine anoxia and delayed Earth system recovery after the end-Permian extinction by Lau, Kimberly V., Maher, Kate, Altiner, Demir, Kelley, Brian M., Kump, Lee R., Lehrmann, Daniel J., Silva-Tamayo, Juan Carlos, Weaver, Karrie L., Yu, Meiyi, Payne, Jonathan L.

“…Delayed Earth system recovery following the end-Permian mass extinction is often attributed to severe ocean anoxia. However, the extent and duration of Early…”
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On the Application of K-User MIMO for 6G Enhanced Mobile Broadband by Yerrapragada, Anil Kumar, Kelley, Brian

“…This paper presents a high-throughput wireless access framework for future 6G networks. This framework, known as K-User MIMO, facilitates all-to-all…”
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POSIT: Flexible Shape-Guided Docking For Pose Prediction by Kelley, Brian P, Brown, Scott P, Warren, Gregory L, Muchmore, Steven W

“…We present a new approach to structure-based drug design (POSIT) rigorously built on the simple concept that pose prediction is intimately coupled to the…”
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Physical Layer Security for 6G: Toward Achieving Intelligent Native Security at Layer-1 by Ara, Israt, Kelley, Brian

“…This paper lays the foundations for Physical Layer Security (PLS) as a native 6G communication operation mode. 6G mobile network will enable intelligent…”
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Monoclonal antibody therapies for COVID-19: lessons learned and implications for the development of future products by Kelley, Brian, De Moor, Pam, Douglas, Kristen, Renshaw, Todd, Traviglia, Stacey

“…Several companies were authorized to treat COVID-19 patients with monoclonal antibodies within 1–2 years of the start of the pandemic. These products were…”
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A Systematic Review of Complications of Implant-based Breast Reconstruction with Prereconstruction and Postreconstruction Radiotherapy by Momoh, Adeyiza O., Ahmed, Raouf, Kelley, Brian P., Aliu, Oluseyi, Kidwell, Kelley M., Kozlow, Jeffrey H., Chung, Kevin C.

“…Purpose To conduct a systematic review of the literature to assess outcomes data on complications associated with implant-based breast reconstruction performed…”
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Targeting of nanoparticles to the cerebral vasculature after traumatic brain injury by Omo-Lamai, Serena, Nong, Jia, Savalia, Krupa, Kelley, Brian J, Wu, Jichuan, Esteves-Reyes, Sahily, Chase, Liam S, Muzykantov, Vladimir R, Marcos-Contreras, Oscar A, Dollé, Jean-Pierre, Smith, Douglas H, Brenner, Jacob S

“…Traumatic brain injury has faced numerous challenges in drug development, primarily due to the difficulty of effectively delivering drugs to the brain…”
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Ibuprofen May Not Increase Bleeding Risk in Plastic Surgery: A Systematic Review and Meta-Analysis by Kelley, Brian P., Bennett, Katelyn G., Chung, Kevin C., Kozlow, Jeffrey H.

“…Nonsteroidal antiinflammatory drugs such as ibuprofen are common medications with multiple useful effects, including pain relief and reduction of inflammation…”
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Prediction of pK a Using Machine Learning Methods with Rooted Topological Torsion Fingerprints: Application to Aliphatic Amines by Lu, Yipin, Anand, Shankara, Shirley, William, Gedeck, Peter, Kelley, Brian P, Skolnik, Suzanne, Rodde, Stephane, Nguyen, Mai, Lindvall, Mika, Jia, Weiping

“…The acid–base dissociation constant, pK a, is a key parameter to define the ionization state of a compound and directly affects its biopharmaceutical profile…”
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Physical Layer Security for Beyond 5G: Ultra Secure Low Latency Communications by Yerrapragada, Anil Kumar, Eisman, Taylor, Kelley, Brian

“…If Beyond-5G(B5G)/6G is to support critical infrastructure worldwide, there must be an effort to jointly integrate low latency and privacy into wireless…”
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To flip or not: Case series of coronary angioplasty in patients with right‐sided heart by Kelley, Brian P., Glasco, Shanice, Sang, Charlie J., Yoo, Bianca, Yeung, Michael, Zhang, Jiandong

“…Coronary angioplasty in patients with a right‐sided heart may be difficult due to challenges in engaging the coronary arteries, interpreting angiogram, and…”
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Essential considerations for using protein–ligand structures in drug discovery by Warren, Gregory L., Do, Thanh D., Kelley, Brian P., Nicholls, Anthony, Warren, Stephen D.

“…► Quality criteria for identification of reliable protein–ligand structures are presented. ► Electron density is essential for structure evaluation in…”
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High-throughput screening of chromatographic separations: I. Method development and column modeling by Coffman, Jonathan L, Kramarczyk, Jack F, Kelley, Brian D

“…The development of purification processes for protein biopharmaceuticals is challenging due to compressed development timelines, long experimental times, and…”
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Persistent Opioid Use and High-Risk Prescribing in Body Contouring Patients by Bennett, Katelyn G., Kelley, Brian P., Vick, Alexis D., Lee, Jay S., Gunaseelan, Vidhya, Brummett, Chad M., Waljee, Jennifer F.

“…Opioid misuse occurs commonly among obese patients and after bariatric surgery. However, the risk of new persistent use following postbariatric body contouring…”
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A Systematic Review of Morbidity Associated with Autologous Breast Reconstruction Before and After Exposure to Radiotherapy: Are Current Practices Ideal? by Kelley, Brian P., Ahmed, Raouf, Kidwell, Kelley M., Kozlow, Jeffrey H., Chung, Kevin C., Momoh, Adeyiza O.

“…Purpose The specific aim of this study was to conduct a systematic review of the literature to assess outcomes data on complications and aesthetic results…”
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Developing, Conducting, and Publishing Appropriate Systematic Review and Meta-Analysis Articles by Kelley, Brian P., Chung, Kevin C.

“…The volume of medical literature is growing at a rate that renders decision-making difficult without specialized summary tools. Systematic reviews and…”
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